Download or read book Investigation of Sweeping as a Sample Enrichment Method in Micellar Electrokinetic Chromatography in the Analysis of Pharmaceutical Preparations and Biological Fluids written by Mohamed Ibraheem Mohamed el- Awady and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of Micellar Electrokinetic Chromatography as an Analytical Technique in Pharmaceutical Analysis an Industrial Perspective written by Karin Stubberud and published by . This book was released on 2002 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stacking and Sweeping in Micellar Electrokinetic Chromatography MEKC for On column Sample Preconcentration of Fungicides written by Na'emah A'ubid and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Green Analytical Chemistry written by Mihkel Koel and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concerns about environmental pollution, global climate change and hazards to human health have increased dramatically. This has led to a call for change in chemical processes including those that are part of chemical analysis. The development of analytical chemistry continues and every new discovery in chemistry, physics, molecular biology, and materials science brings new opportunities and challenges. Yet, contemporary analytical chemistry does not consume resources optimally. Indeed, the usage of toxic chemical compounds is at the highest rate ever. All this makes the emerging field of green chemistry a “hot topic” in industrial, governmental laboratories as well as in academia. This book starts by introducing the twelve principles of green chemistry. It then goes on to discuss how the principles of green chemistry can be used to assess the ‘greenness’ of analytical methodologies. The ‘green profile’ proposed by the ACS Green Chemistry Institute is also presented. A chapter on “Greening” sample preparation describes approaches to minimizing toxic solvent use, using non-toxic alternatives, and saving energy. The chapter on instrumental methods describes existing analytical approaches that are inherently green and making non-green methods greener. The final chapter on signal acquisition describes how quantitative structure-property relationship (QSPR) ideas could reduce experimental work thus making analysis greener. The book concludes with a discussion of how green chemistry is both possible and necessary. Green Analytical Chemistry is aimed at managers of analytical laboratories but will also interest teachers of analytical chemistry and green public policy makers.
Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 2028 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Introduction to Pharmaceutical Chemical Analysis written by Steen Honoré Hansen and published by John Wiley & Sons. This book was released on 2011-10-18 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide. In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the pharmacy student, to teach the requirements in “analytical chemistry” for the 5 years pharmacy curriculum, but the textbook is also intended for analytical chemists moving into the field of pharmaceutical analysis. Addresses the basic concepts, then establishes the foundations for the common analytical methods that are currently used in the quantitative and qualitative chemical analysis of pharmaceutical drugs Provides an understanding of common analytical techniques used in all areas of pharmaceutical development Suitable for a foundation course in chemical and pharmaceutical sciences Aimed at undergraduate students of degrees in Pharmaceutical Science/Chemistry Analytical Science/Chemistry, Forensic analysis Includes many illustrative examples
Download or read book Solvent Microextraction written by John M Kokosa and published by John Wiley & Sons. This book was released on 2009-10-05 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers both a practical as well a theoretical approach to Solvent Microextraction (SME) and will help analytical chemists to evaluate SME for a given sample preparation. Introductory chapters overview a comparison of SME with other sample preparation methods, a summary of the technical aspects, and a detailed theoretical treatment of SME. The book then describes the practical aspects of the technique, with detailed “how to” chapters devoted to the preparation and analysis of atmospheric, solid and liquid environmental, clinical and industrial samples. This text will serve as both a handy laboratory desk-reference and an indispensible instructional tool.
Download or read book Applications of Ion Exchange Materials in Biomedical Industries written by Inamuddin and published by Springer. This book was released on 2019-01-30 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the applications of ion-exchange materials in the biomedical industries. It includes topics related to the application of ion exchange chromatography in determination, extraction and separation of various compounds such as amino acids, morphine, antibiotics, nucleotides, penicillin and many more. This title is a highly valuable source of knowledge on ion-exchange materials and their applications suitable for postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology. Additionally, this book will provide an in-depth knowledge of ion-exchange column and operations suitable for engineers and industrialists.
Download or read book In tip Solid Phase Microextraction for High Throughput Drug Analysis written by Wei Xie and published by . This book was released on 2011 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the design of a convenient format of solid phase microextraction (SPME) for bioanalysis in pharmaceutical industry and the validation of the approach to the application. An automated in-tip SPME technique coupled with liquid chromatography (LC) and tandem mass spectrometry (MS/MS) for high throughout drug analysis has been developed and applied to the quantitative determination of various drug compounds in different biological fluids from drug discovery to clinical development. The initial research in this thesis focused on a proof-of-concept study using manual multi-fiber approach to determine a drug compound in human plasma from a clinical trial. The proof-of-concept was achieved based on the validation data and a head-to-head comparison with conventional liquid-liquid extraction (LLE) method. An in-tip SPME technique was then proposed to explore the feasibility of SPME automation and two approaches of preparing in-tip SPME fibers were developed including fiber-packed and sorbent-packed fiber preparation. A simple and high throughput in-tip SPME fiber fabricating procedure based on polymer monoliths using photo-polymerization was introduced to prepare 96 fibers simultaneously. The biggest advantage of the in-tip SPME technique is that it is simple and easy to use for automation without introducing any additional devices and in the meantime, the simplicity of SPME is maintained. Automated in-tip SPME was applied to routine drug analysis in drug discovery and development environment. One case study involved the determination of vitamin D3 in human serum with derivatization and the in-tip SPME approach was compared with traditional LLE method using either tubes or 96-well plate extraction. Another study was to use hydrophilic interaction chromatography (HILIC) -MS/MS to determine three polar compounds, imipenem (IMP), cliastatin (CIL) and [beta]-lactamase inhibitor (BLI) simultaneously in different biological fluids including rat plasma and mouse blood. The results from both studies clearly demonstrated that in-tip SPME could be used as an alternative sample preparation method in bioanalytical analysis. Matrix effects in bioanalysis using automated in-tip SPME and LC-MS/MS were then thoroughly evaluated for the first time. Our study indicated that the assumption that SPME should provide sample clean up as effective as or better than solid phase extraction (SPE) with no or minimal matrix effects might not be always true, and matrix effects should be investigated in any SPME assays in bioanalysis.
Download or read book Capillary Zone Electrophoresis written by František Foret and published by . This book was released on 1993 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Liquid Phase Extraction written by Colin F. Poole and published by Handbooks in Separation Scienc. This book was released on 2019-09 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Phase Extraction thoroughly presents both existing and new techniques in liquid phase extraction. It not only provides all information laboratory scientists need for choosing and utilizing suitable sample preparation procedures for any kind of sample, but also showcases the contemporary uses of sample preparation techniques in the most important industrial and academic project environments, including countercurrent chromatography, pressurized-liquid extraction, single-drop Microextraction, and more. Written by recognized experts in their respective fields, it serves as a one-stop reference for those who need to know which technique to choose for liquid phase extraction. Used in conjunction with a similar release, Solid Phase Extraction, it allows users to master this crucial aspect of sample preparation. Defines the current state-of-the-art in extraction techniques and the methods and procedures for implementing them in laboratory practice Includes extensive referencing that facilitates the identification of key information Aimed at both entry-level scientists and those who want to explore new techniques and methods
Download or read book Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation written by S.A. Westwood and published by Springer. This book was released on 2012-10-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana lysis. The driving force for this development is the need for automated, sim pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur ther with spectroscopic techniques, such as Fourier transform infrared, ultra violet or mass spectrometry, to provide specific identification or structural information.
Download or read book Proteomics Sample Preparation written by Jörg von Hagen and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
Download or read book Challenges in Analytical Quality Assurance written by Manfred Reichenbächer and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Working in the lab, but unsure what your results actually mean? Would you like to know how to apply trueness tests, calculate standard deviations, estimate measurement uncertainties or test for linearity? This book offers you a problem-based approach to analytical quality assurance (AQA). After a short introduction into required fundamentals, various topics such as statistical tests, linear regression and calibration, tool qualification or method validation are presented in the form of exercises for self-study. Solutions are provided in a clear step-by-step manner. Interactive Excel-sheets are available as Extra Materials for trying out the various concepts. For professionals as well as graduate students confronted with analytical quality assurance for the first time, this book will be the clue to meeting such challenges.
Download or read book Advances in the Applications of Membrane Mimetic Chemistry written by J. H. Fendler and published by . This book was released on 1995-01-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sample Preparation of Pharmaceutical Dosage Forms written by Beverly Nickerson and published by Springer Science & Business Media. This book was released on 2011-08-05 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. This book is divided into four parts: • Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. • Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms. • Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods. • Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.
Download or read book Recent Advances in Environmental Analysis written by Roland W. Frei and published by Routledge. This book was released on 1979 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The articles published in this book first appeared in the International journal of environmental analytical chemistry, volumes 5 and 6, number 4, and numbers 1 and 3. Some were published in Toxicological and environmental chemistry reviews, volume 2, numbers 3 and 4."
