Download or read book Investigation of Marine derived Fungi for Bioactive Natural Products written by Timothy Scott Bugni and published by . This book was released on 2003 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Natural Products from Marine Fungi written by Hee Jae Shin and published by MDPI. This book was released on 2021-01-20 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine fungal natural products are well-known as the “blue gold,” as they have been promising leads for drug discovery and development. Even though marine fungi are less explored in comparison to their terrestrial counterparts, a number of useful hits have been obtained from a drug discovery perspective. Topics discussed in this book include a review on novel natural products from extremophilic fungi, secondary metabolites from deep-sea fungi; natural products from fungi in a symbiotic relationship with marine macro-organisms; and bioactive metabolites from sediment-derived fungi. Marine biologists, chemists, and pharmacologists will find the book a good reference material. The book covers various bioactive marine fungal natural products, and it is hoped that this book aids scientists explore fungal chemical diversity.

Download or read book Marine Microbial Diversity as a Source of Bioactive Natural Products written by Didier Stien and published by MDPI. This book was released on 2020-06-17 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: A trillion different microbial species have been evolving for some 3.5 billion years, producing ever more complex active secondary metabolites. The sea is a cauldron of a great diversity of useful and valuable compounds. This Special Issue focused on studies of marine microbe natural products for discovering compounds useful to humankind. Papers were collected that provide up-to-date information regarding the characterization of marine microbes’ metabolic diversity and the evaluation of the therapeutic potential of marine microbes’ metabolites. Most of the articles in this book deal with marine fungi, biological and chemical diversity, and their active metabolites. This may be a sign that marine fungi have been under studied to date and are perceived by many researchers as an important source of discovery in this field. A best practices guide for the isolation of marine fungi from different matrixes and their conservation is also presented. The comparison of the phylogenetic and metabolomic profiles of microalgae from different lineages provides novel insights into the potential of chemotaxonomy in marine phytoplankton, showing a good overlap of phylogenetic and chemotaxonomic signals.

Download or read book Diversity of Marine Fungi as a Source of Bioactive Natural Products written by and published by . This book was released on 2023-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioactive Compounds from Marine Derived Aspergillus Penicillium Talaromyces and Trichoderma Species written by Rosario Nicoletti and published by MDPI. This book was released on 2019-05-27 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Colleagues,The importance of bioactive natural compounds in pharmacology and other biotechnological fields has stimulated the scientific community to explore new environmental contexts and their associated microbial diversity. As the largest frontier in biological discovery, the sea represents a significant source of organisms producing novel secondary metabolites with interesting bioactivities. Of the available biological material, fungi have received increasing consideration, both due to their pervasive occurrence in varying habitats as well as their aptitude to develop symbiotic associations with higher organisms in numerous contexts. In many cases, fungal strains have been reported as the real producers of drugs originally extracted from marine plants and animals. Due to the constantly increasing number of marine-derived fungi yielding valuable bioactive products, it is now appropriate to present these findings to a recipient audience in a more organized form.This Special Issue of Marine Drugs, entitled “Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces, and Trichoderma Species”, is specifically focused on a few genera of ascomycetous fungi which are widespread regarding marine contexts and are particularly inclined to establishing symbiotic relationships. For this project, we welcome submissions of full research papers, short notes, and review articles reporting the discovery and characterization of products showing antibiotic, antitumor, antiviral, insecticidal, antimalarial, antifouling, antioxidant, plant growth-promoting and/or resistance-inducing, as well as other less-exploited activities.Dr. Rosario Nicoletti Dr. Francesco Vinale Guest Editors

Download or read book Bioactive Marine Natural Products written by Dewan S. Bhakuni and published by Springer Science & Business Media. This book was released on 2006-06-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Download or read book Marine derived Fungi written by Claudia M. Boot and published by . This book was released on 2007 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biological and Chemical Investigations of Indonesian Marine Derived Fungi and their Secondary Metabolites written by Kustiariyah Tarman and published by Cuvillier Verlag. This book was released on 2011-04-04 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the search for bioactive compounds, 32 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. Bioassay-guided fractionation led to the isolation of bioactive compounds. Altogether 14 compounds were isolated and further elucidated. The compounds were obtained from the ethyl acetate and dichloromethane extracts of six fungal strains. They included 9 polyketides, 2 terpenes, 1 alkaloid and 2 till now undefined structures.

Download or read book Investigations of Natural Products from Marine Sponge Derived Fungi written by Leif Martin Abrell and published by . This book was released on 1997 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress in the Chemistry of Organic Natural Products 111 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-02-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.

Download or read book Investigation of Marine derived Bacteria for Bioactive Natural Products written by and published by . This book was released on 2014 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have historically been a rich source for therapeutics and therapeutic leads. In particular, the marine environment has offered a virtually untapped resource for unique chemical scaffolds with therapeutic potential. Despite the success of natural products in the development of therapeutics, the hit-to-lead process still remains a major bottleneck in drug development. Chemical rediscovery, as well as the challenges of structure elucidation, have historically been major obstacles in the discovery of novel natural products. This dissertation explores methods to minimize these obstacles, and novel natural products with therapeutic potential are presented as a result of these methods. To address the obstacles of chemical rediscovery, LCMS-based metabolomics was used as a tool for bacterial strain selection. Principal component analysis (PCA) of LCMS data from marine-derived bacterial extracts allowed for a spatial distribution of the chemistry produced. PCA allowed for selection of bacterial strains (WMMB499, WMMB215), and subsequent fermentation, isolation, and structure elucidation led to 12 novel structures (peptidolipins B-F, halomadurones A-D, ecteinamycin, and forazolines A and B). To address the challenges of structure elucidation, a method of 13C incorporation and subsequent acquisition of 13C-13C COSY NMR allowed for rapid structure elucidation of bacterial-derived natural products (ecteinamycin and forazoline A). Most importantly, the 17 novel natural products presented in this dissertation demonstrated a vast array of therapeutic potential, including antibacterial (peptidolipins B-F and ecteinamycin), anti-cancer (thiocoraline and novel analogs), anti-neurodegenerative (halomadurones A-D), and antifungal (forazolines A and B) activity; forazoline A demonstrated in vivo efficacy. Additional work is necessary for these compounds to continue down the drug development pipeline, but overall, they provide an example for the utility of methods, such as LCMS-based metabolomics and 13C-labeling of bacterial-derived natural products, for improving the efficiency of the hit-to-lead process. Ultimately, the novel structures presented in this dissertation reinforce the potential of the marine environment as a source for therapeutics and therapeutic leads.

Download or read book Fungi Bioactive Metabolites written by Sunil Kumar Deshmukh and published by Springer Nature. This book was released on with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioactive Natural products in Drug Discovery written by Joginder Singh and published by Springer Nature. This book was released on 2020-04-30 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Download or read book Natural Products from Marine Fungi written by Hee Jae Shin and published by . This book was released on 2020 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine fungal natural products are well-known as the “blue gold,” as they have been promising leads for drug discovery and development. Even though marine fungi are less explored in comparison to their terrestrial counterparts, a number of useful hits have been obtained from a drug discovery perspective. Topics discussed in this book include a review on novel natural products from extremophilic fungi, secondary metabolites from deep-sea fungi; natural products from fungi in a symbiotic relationship with marine macro-organisms; and bioactive metabolites from sediment-derived fungi. Marine biologists, chemists, and pharmacologists will find the book a good reference material. The book covers various bioactive marine fungal natural products, and it is hoped that this book aids scientists explore fungal chemical diversity.

Download or read book Sponges Porifera written by Werner E. G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sponges (phylum Porifera) are known to be very rich sources for bioactive compounds, mainly secondary metabolites. Main efforts are devoted to cell- and mariculture of sponges to assure a sustainable exploitation of bioactive compounds from biological starting material. These activities are flanked by improved technologies to cultivate bacteria and fungi which are associated with the sponges. It is the hope that by elucidating the strategies of interaction between microorganisms and their host (sponge), by modern cell and molecular biological methods, a more comprehensive cultivation of the symbiotic organisms will be possible. The next step in the transfer of knowledge to biotechnological applications is the isolation, characterization and structural determination of the bioactive compounds by sophisticated chemical approaches.

Download or read book Marine Microbiology written by Se-Kwon Kim and published by John Wiley & Sons. This book was released on 2013-06-21 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deliberately breaking with the classical biology-centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high-value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues. Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward-looking resource for innovative biotechnologists in industry as well as in academia.

Download or read book Natural Medicinal Compounds from Marine Fungi Towards Drug Discovery written by Brindha Devi Parthiban and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine fungi are species of fungi which live in estuaries environment and marine environment. These species are found in common habitat. Marine fungi are rich in antimicrobial compounds such as anthrones, cephalosporins, peptides, steroids. These compounds which are derived mainly focused in the area of anti-inflammatory, anti-oxidant, anti-fungal, anti-microbial, anti-fouling activity. Bioactive terpene compounds are produced by marine fungi and marine derived fungi can produce sclerotides, trichoderins. Marine fungi have become the richest sources of biologically active metabolites and structurally novel in the marine environment. In a recent study the marine derived fungi dichotomomyces cejpii exhibits activity towards cannabinoid which is used to treat alzheimer dementia. Aspergillus unguis showed significant acetyl cholinesterase besides its anti-oxidant activity. These acts as a promising intent for discovery of pharmaceutically important metabolites like alkaloids, peptides. Computational (in silico) strategies have been developed and broadly applied to pharmacology advancement and testing. This review summarizes the bioactive compounds derived from marine fungi in accordance with the sources and their biological activities.