Download or read book Investigation of Gene environment Interaction Between Vitamin D and the Colorectal Cancer Susceptibility Genetic Variant Rs9929218 written by Peter Gregory Vaughan-Shaw and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Genomics Interrogation of Gene environment Interactions Between Vitamin D and Genetic Variants Associated with Colorectal Cancer Susceptibility written by James Blackmur and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diet Inflammation and Genetic Predictors of Tissue specific Gene Expression written by Paneen S. Petersen and published by . This book was released on 2020 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is the second most commonly diagnosed cancer in both sexes combined worldwide, as well as the second leading cause of cancer deaths. Pathogenesis of CRC can be attributed to both genetic (G) and environmental (E) factors. Among environmental risk factors, dietary factors contribute significantly to the etiology of CRC. Extensive research has focused on relationships between dietary factors, food constituents, and dietary patterns to CRC risk. There is compelling evidence from observational studies which supports the carcinogenicity of increased consumption of processed meat, and red meat. Evidence for protective effects of fruit, vegetable, whole grains, or fiber intake is less certain. Dietary factors may also have a direct effect on CRC risk by modifying the effect of genetic predisposition for CRC. Furthermore, evidence for a relationship between inflammation and cancer has also been established by previous epidemiological studies as well as through basic research, yet mechanisms that underlie the association between inflammation and CRC remain uncertain. C-reactive protein (CRP) is a positive acute-phase protein produced primarily in the liver as a response to infection, tissue injury, and systemic inflammation. Circulating levels of CRP are commonly used as a measure of chronic inflammation, and pre-diagnostic serum CRP has been associated with increased risk of CRC in previous studies. This dissertation research project utilized self-reported dietary histories and measures of circulating C-reactive protein to examine the interaction between these risk factors and genetic variation on the risk of colorectal cancer. Utilizing genotype array data from both population-based case-control studies and nested case-control studies in an international collaboration of well-characterized studies, the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), we employed a novel statistical approach to reduce multiple testing burden and increase power with a priori functional information from predicted tissue-specific gene expression. Our GxE analysis for dietary factors had a study sample comprised of 22 studies with 20,236 cases and 19,838 controls. In our dietary GxE analysis we detected a significant interaction (P = 2.30 x10−7) between processed meat intake and variants predictive of RAC Family Small GTPase 1 (RAC1) gene expression in the colon and risk of CRC. The most significant interaction of a single variant within RAC1 was rs2346263 ([Betat subscript[GE]] = -0.127; P = 1.32 x 10−4). In our CRP GxE analysis of 5 studies comprising 5,423 individuals, we observed a 4 % increase of risk of CRC from a two-fold rise in CRP (mg/L) levels [OR:1.04 (95% CI:1.00, 1.08)]. There was significant heterogeneity in study specific effect sizes for the circulating CRP [P = 7.6 x 10−3]. At an FDR

Download or read book Cancer written by Vincent T. DeVita and published by Lippincott Williams & Wilkins. This book was released on 2011 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of Oncology, this unique publication brings together the basic scientific information on the molecular biology of cancer. The format is designed to be useful both to research scientists interested in the study of cancer and to oncologists who need to understand these new developments that are having a profound impact on the care of patients with cancer. Leading scientists and clinicians in the field of molecular biology and clinical oncology have lent their expertise to this project. The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells. Part II includes an up-to-date description of how this new information has affected the understanding of the biology of 19 of the most common cancers, with an emphasis on how these new findings have been translated to impact the management of cancer patients. This distinctive text provides a single concise source of information for scientists and clinicians in this rapidly developing field.

Download or read book The Molecular Basis of Human Cancer written by William B. Coleman and published by Humana Press. This book was released on 2016-11-11 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

Download or read book Feature Extraction written by Isabelle Guyon and published by Springer. This book was released on 2008-11-16 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is both a reference for engineers and scientists and a teaching resource, featuring tutorial chapters and research papers on feature extraction. Until now there has been insufficient consideration of feature selection algorithms, no unified presentation of leading methods, and no systematic comparisons.

Download or read book Machine Learning and Knowledge Discovery in Databases written by Walter Daelemans and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the joint conference on Machine Learning and Knowledge Discovery in Databases: ECML PKDD 2008, held in Antwerp, Belgium, in September 2008. The 100 papers presented in two volumes, together with 5 invited talks, were carefully reviewed and selected from 521 submissions. In addition to the regular papers the volume contains 14 abstracts of papers appearing in full version in the Machine Learning Journal and the Knowledge Discovery and Databases Journal of Springer. The conference intends to provide an international forum for the discussion of the latest high quality research results in all areas related to machine learning and knowledge discovery in databases. The topics addressed are application of machine learning and data mining methods to real-world problems, particularly exploratory research that describes novel learning and mining tasks and applications requiring non-standard techniques.

Download or read book Intelligent Engineering Informatics written by Vikrant Bhateja and published by Springer. This book was released on 2018-04-10 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the proceedings of the 6th International Conference on Frontiers of Intelligent Computing: Theory and Applications (FICTA 2017), held in Bhubaneswar, Odisha. The event brought together researchers, scientists, engineers, and practitioners to exchange their new ideas and experiences in the domain of intelligent computing theories with prospective applications to various engineering disciplines. The book is divided into two volumes: Information and Decision Sciences, and Intelligent Engineering Informatics. This volume covers broad areas of Intelligent Engineering Informatics, with papers exploring both the theoretical and practical aspects of various areas like ANN and genetic algorithms, human–computer interaction, intelligent control optimisation, intelligent e-learning systems, machine learning, mobile computing, multi-agent systems, etc. The book also offers a valuable resource for students at the post-graduate level in various engineering disciplines.