Download or read book Intrinsic mutagenesis written by Burnet MacFarlane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Download or read book Mutagenicity Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Download or read book Chance and Necessity written by Jacques Monod and published by . This book was released on 1997 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Change and necessity is a statement of Darwinian natural selection as a process driven by chance necessity, devoid of purpose or intent.
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aging in Today s Environment written by National Research Council (U.S.). Committee on Chemical Toxicity and Aging and published by National Academies. This book was released on 1987 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report examines the relationships between aging and exposure to environmental agents (including natural and man-made agents, as well as life-style factors). Several relationships must be considered--the impact of intermittent or lifelong exposure to environmental agents on the rate of aging, the impact of lifelong exposure on health status when one reaches more advanced age, and the special response of the aged compared with that of the young when exposed to environmental agents.
Download or read book Directed Evolution written by Andrew Currin and published by Springer Nature. This book was released on 2022-06-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest techniques used by researchers to study directed evolution (DE) at each stage of the Design-Build-Test-Learn cycle. Chapters in this book cover topics such as designing overlap extension PCR primers for protein mutagenesis; antha-guided automation of Darwin assembly for the construction of bespoke gene libraries; rapid cloning of random mutagenesis libraries using PTO-Quickstep; and DE of glycosyltransferases by a single-cell screening method. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Directed Evolution: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this field and incorporating these studies into new experimental workflows.
Download or read book Manual on MUTATION BREEDING THIRD EDITION written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2018-10-09 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides guidelines for new high-throughput screening methods – both phenotypic and genotypic – to enable the detection of rare mutant traits, and reviews techniques for increasing the efficiency of crop mutation breeding.
Download or read book Molecular Basis of Aging written by Alvaro Macieira-Coelho and published by CRC Press. This book was released on 2017-11-22 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of:
Download or read book Encyclopedia of Microbiology written by Thomas M. Schmidt and published by Academic Press. This book was released on 2019-09-11 with total page 3248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Microbiology, Fourth Edition, Five Volume Set gathers both basic and applied dimensions in this dynamic field that includes virtually all environments on Earth. This range attracts a growing number of cross-disciplinary studies, which the encyclopedia makes available to readers from diverse educational backgrounds. The new edition builds on the solid foundation established in earlier versions, adding new material that reflects recent advances in the field. New focus areas include `Animal and Plant Microbiomes’ and ‘Global Impact of Microbes`. The thematic organization of the work allows users to focus on specific areas, e.g., for didactical purposes, while also browsing for topics in different areas. Offers an up-to-date and authoritative resource that covers the entire field of microbiology, from basic principles, to applied technologies Provides an organic overview that is useful to academic teachers and scientists from different backgrounds Includes chapters that are enriched with figures and graphs, and that can be easily consulted in isolation to find fundamental definitions and concepts
Download or read book Lewis s Medical Surgical Nursing E Book written by Diane Brown and published by Elsevier Health Sciences. This book was released on 2011-11-21 with total page 5337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully-revised new edition of Australia and New Zealand’s most highly esteemed medical-surgical nursing text. The thoroughly revised third edition of Lewis’s Medical–Surgical Nursing builds on the respected quality content of its previous editions. Authored by Di Brown and Helen Edwards with contributions from an impressive pedigree of leading academics and clinical experts, this latest edition cements Lewis’s position as the region’s premier medical-surgical nursing textbook. Fully updated, this hardback nursing text reflects recent changes in clinical nursing practice in Australia and New Zealand. Its local focus is strengthened by up-to-date research, data, policies, procedures and guidelines with an emphasis on current issues. All text in Lewis’s Medical–Surgical Nursing is underpinned by evidence-based practice with an emphasis on the pathophysiological mechanisms of disease. Lewis’s Medical–Surgical Nursing 3e provides nurses in Australia and New Zealand with clear and concise guidance on the assessment and management of conditions. The content is arranged by body systems and addresses myriad conditions relevant to medical-surgical nursing, including respiratory problems, cardiovascular disease, cancer, gastrointestinal problems, renal and urological problems, reproductive problems, movement and coordination and emergency care. Lewis’s Medical–Surgical Nursing 3e by Brown and Edwards is accompanied by an impressive suite of resources for instructors and students including a test bank, image banks and PowerPoint slides available on Elsevier’s Evolve website. Also available for purchase separately are companion publications Simulation Learning System for Lewis's Medical-Surgical Nursing (9780729541060 AU $89.95) ANZ adaptation by Karen Wotton & Mark Neill and Clinical Companion for Medical-Surgical Nursing 2e (9780729539968 AU $ 49.95) by Gayle McKenzie and Tanya Porter together form a highly comprehensive learning package. • Learning Objectives • Key Terms • Each section is organised into two themes: Assessment and Management • Assessment chapters focus on the body systems; outlining anatomy and physiology, health history and physical assessment skills • Management chapters focus on pathophysiology, clinical manifestations, collaborative care and nursing management of disease and disorders • Features boxes include: o Nursing Research o Evidence Based Practice o Clinical Practice o Health Promotion o Complementary and Alternative therapies o Health Disparities • Tables featuring the most up-to-date data for ANZ • Boxed information across a range of nursing care issues • Nursing care plans • Case studies accompanied by critical thinking questions • Multiple choice review questions at the end of each chapter • Extensive References and Online Resources listed at the end of each chapter for further research • Evolve and resources
Download or read book The Genetics of Aging written by Edward Schneider and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been proposed for the mechanisms of aging at the molecular level and present data which either support or contradict these hypotheses. Subsequent chapters will deal with the genetics of aging in organisms ranging from paramecium to mammals. The largest section of this volume will be devoted to several important areas in human genetics: human genetic disorders which feature premature aging, the effect of human parental aging on the production of genetically abnor mal offspring, the genetics of human longevity, and a review of studies on aging human twins. Over the last few decades genetic technology has provided enormous insight into a number of disciplines. Therefore, in the last few chapters, several genetic approaches to the study of aging are discussed: somatic cell genetics, immunogenetics, and behavioral genetics. As the goal of this volume is to present a comprehensive examination of the genetics of aging, most chapters are oriented toward general review of their respective areas. It is my hope that this volume will encourage clinical, biological, and behavioral investigators to turn their attention to the genetic aspects of aging as well as to employ genetic technology to obtain further insight into aging processes.
Download or read book The Molecular Genetics of Lung Cancer written by David N Cooper and published by Springer Science & Business Media. This book was released on 2005-11-20 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Download or read book Genetics Evolution and Radiation written by Victoria L. Korogodina and published by Springer. This book was released on 2017-03-28 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to the great scientist and outstanding individual Nikolay Wladimirovich Timofeeff-Ressovsky. The book brings together a number of brief stories/essays about Timofeeff-Ressovsky including “Stories told by himself”, and scientific chapters addressing his major research areas: genetics, radiobiology, radiation ecology and epidemiology, and evolution. Timofeeff-Ressovsky contributed to several fields of biology and established new directions of scientific research. He often repeated the phrase, which would later become famous: “Science should not be approached with the ferocity of wild animals”. In keeping with that philosophy, the issues discussed here are still open. Each scientific part starts with a current review; the chapters present leading scientific schools and views. The main theme discussed in the genetics part is mutation variability in the context of linear (replication, transcription, translation) and conformational template processes, and its dependence on phylogenetic group. In turn, the radiobiology chapters focus on the reorganization of DNA, cell, and population variability under low-dose irradiation, sparking indirect processes and adaptive response. The radiation ecology and epidemiology parts present data on the consequences of nuclear plants and related accidents for ecological systems and human beings. Here some approaches to estimating radiation risks are also offered. Evolution laws are demonstrated in the genomic universe, plant-microbe symbiosis, stabilizing and destabilizing (directional) selection. The last essay demonstrates the principles of organization operating in local animal populations, which are approached as social organisms of complex systemic nature. The chapter 'Radiation-Induced Aging and Genetic Instability of Mesenchymal Stem Cells: An Issue for Late Health Effects?' is available open access under a CC BY 4.0 license.
Download or read book Physical Therapy Clinical Handbook for PTAs written by Kathy Cikulin-Kulinski and published by Jones & Bartlett Learning. This book was released on 2017-02-10 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Therapy Clinical Handbook for PTAs,Third Edition is a concise and condensed clinical guide designed specifically to help physical therapist assistants and students easily obtain helpful evidence-based information.
Download or read book Physical Therapy Clinical Handbook for PTAs written by Olga Dreeben-Irimia and published by Jones & Bartlett Publishers. This book was released on 2013 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Therapy Clinical Handbook for PTAs, Second Edition, is a concise and condensed clinical pocket guide designed specifically to help physical therapist assistants and physical therapist assistant students easily obtain helpful evidence-based information. This succinct, summarizing pocket-guide covers the evaluative as well as interventional aspect of physical therapy and offers immediate guidance concerning physical therapy data collection and interventions in various clinical settings including musculoskeletal, neurologic, cardiopulmonary, integumentary, geriatric, pediatric and acute care. With its portable and user-friendly format, this handbook is a valuable resource for physical therapist assistant students during the education training program and throughout clinical practice. The Second Edition features a new and unique look at physical therapy in acute care provided by PTAs. Acute care topics include musculoskeletal and neurological acute care, as well as the significant factors in acute care to consider while applying physical therapy to patients with endocrine, gastrointestinal, genitourinary, and oncological disorders/diseases. The Second Edition contains physical therapy terminology reflecting current physical therapy practice according to the APTA's "Guide to Physical Therapist Practice" and also includes guidelines from the CDC and JCAHO. Appendices contain helpful balance assessment forms, and cardiac and integumentary patient education forms.
