Download or read book Intervertebral Disc Regeneration II written by Benjamin Gantenbein and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration

Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Springer Nature. This book was released on 2022-06-01 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration

Download or read book Intervertebral Disc Regeneration written by Benjamin Gantenbein and published by Mdpi AG. This book was released on 2022-01-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.

Download or read book Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians written by Roger Härtl and published by Thieme Medical Publishers. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human spinal disc : relevant anatomy and physiology / Julien Tremblay-Gravel, Fahad H. Abduljabbar, Jean Ouellet, and Lisbet Haglund -- Pathophysiology of disc disease : disc degeneration / Niloofar Farhang, Joshua Stover, Brandon Lawrence, and Robby D. Bowles -- Imaging of the healthy and diseased spinal disc / Darryl B. Sneag and Hollis G. Potter -- Biomechanics of the healthy and diseased spine / Hans-Joachim Wilke and Fabio Galbusera -- Differences between human and animal discs : pros and cons of current animal models for pre-clinical development of biologic therapies for low back pain / Jeffrey C. Lotz -- Grading scales for disc degeneration and regeneration : clinical and experimental / Peter Grunert -- Disc regeneration : in vitro approaches and experimental results / John T. Martin, Harvey E. Smith, Lachlan J. Smith, and Robert L. Mauck -- Intervertebral disc whole organ cultures / Marianna Peroglio, Zhen Li, Lorin Michael Benneker, Mauro Alini, and Sibylle Grad -- Biological treatment approaches : basic ideas and principles / Victor Y. Leung and Kenneth M. Cheung -- Learning from successes of tissue engineered strategies in non-spine cartilaginous disorders / Stephen Sloan and Lawrence J. Bonassar -- Treatment and of degenerative disc disease and disc regeneration : proteins and genes / Daisuke Sakai and Jordy Schol -- Treatment of degenerated disc disease/disc regeneration : growth factors and platelet-rich plasma / Koichi Masuda and Kenji Kato -- Treatment of degenerated disc disease/disc regeneration : stem cells, chondrocytes or other cells, and tissue engineering / Steven Presciutti and Howard An -- Nucleus replacement and repair : autologous disc chondrocyte transplantation / Christian Hohaus, Timothy Ganey, and Hans Jörg Meisel -- Annulus fibrosus repair / Olivia M. Torre, Michelle A. Cruz, Andrew C. Hecht, and James C. Iatridis -- Summary of clinical trials with biological treatment approaches for spinal disease / Gernot Lang, Ibrahim Hussain, Micaella Zubkov, Yu Moriguchi, Brenton Pennicooke, and Roger Härtl -- Total disc transplantation : current results and future development / Jason Pui Yin Cheung, Dike Ruan, and Keith D.K. Luk -- What have we learned from mechanical total disc replacement? / Timothy T. Roberts, Colin M. Haines, and Edward C. Benzel -- Regulatory overview : obtaining regulatory approval of a biologic/cell product / Michaela H. Purcell, Penny J. White, H. Davis Adkisson -- What makes biological treatment strategies and tissue engineering for ddd interesting to industry? / Hassan Serhan, Elliott A. Gruskin, and William C. Horton -- What will the future bring? : perspectives from around the world / Tony Goldschlager, Claudius Thome, Howard An, and Luiz Vialle

Download or read book The Intervertebral Disc written by Irving M. Shapiro and published by Springer Science & Business Media. This book was released on 2013-09-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.

Download or read book Intervertebral Disc Regeneration written by Benjamin Gantenbein and published by . This book was released on 2022 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.

Download or read book Mesenchymal Stem Cells written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-11-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.

Download or read book The Disc and Degenerative Disc Disease written by Luigi Manfrè and published by Springer Nature. This book was released on 2021-01-05 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This easy-to-consult guide examines the most advanced techniques in the radiological evaluation of the disc and degenerative disc disease, using conventional, functional, dynamic and advanced imaging. It provides clear information on a range of CT, X-ray, and MRI guided techniques, presents all disc treatments in connection with symptomatic disc herniations, evaluates conservative, chemical (ESI, steroid, Ozone, ethanol gel injections) and physical treatments (coblation, laser, decompressors, endoscopy), and assesses the possibility of repairing and/or regenerating the disc in the context of reversible disc degeneration. Like other books in the Springer series New Procedures in Spinal Interventional Neuroradiology, this practice-oriented volume will fill a significant gap in the literature and meet the need expressed by many specialists (interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists) for a topical and handy guide that specifically illustrates the currently available materials and methods.

Download or read book Arthroplasty of the Spine written by Robert Gunzburg and published by Springer Science & Business Media. This book was released on 2003-12-02 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joint replacement is a logical step in the treatment of severe joint pathologies with irreversible lesions resisting conservative therapy. At the spinal level, arthrodesis became, very early, the gold standard of treatment for severe intervertebral disc pathologies. The next logical step was to envision functional replacement, and this step was taken as early as 1956, when the first intervertebral implant was described. However, it took many more years and a great variety of proposed implant designs before clinical applications could be attempted.

Download or read book Current Techniques in Canine and Feline Neurosurgery written by Andy Shores and published by John Wiley & Sons. This book was released on 2017-08-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Techniques in Canine and Feline Neurosurgery offers state-of-the-art, detailed guidance on performing neurosurgical techniques in dogs and cats, from indications and surgical anatomy to procedures and post-operative care. Presents an up-to-date, detailed reference on veterinary neurosurgery techniques, covering skills ranging from basic to advanced Provides guidance on why, when, and how to perform neurosurgical procedures Includes information on diagnostic evaluation, surgical planning, and instrumentation as well as step-by-step descriptions of specific procedures Copublished with the American College of Veterinary Surgeons Foundation and American College of Veterinary Internal Medicine Offers video clips on a companion website

Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Download or read book Unilateral Biportal Endoscopic Spine Surgery written by Dong Hwa Heo and published by Springer Nature. This book was released on 2022-05-22 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biportal endoscopic spine surgery has been rapidly developed recently, and Unilateral biportal endoscopic spine (UBE) surgery may be new stream in spine surgery. UBE surgery is a new concept of surgery that is different from the existing one portal endoscopic surgery, and has the advantage of being familiar with spinal surgeons as the surgical anatomy is similar to a general surgical method, and the learning curve period is short. The 4mm diameter endoscope provides a very clear image, and it can be safely operated under magnified and clear endoscopic view. It is also available to use general surgical instruments in addition to endoscopic surgical instruments during UBE approaches. Currently it is being performed not only in the lumbar spine, but also in the cervical and thoracic spine. In addition, simple laminectomy, disc removal, and spinal fusion are possible. With the advancement of UBE surgery, spinal surgeons from various countries have been performing UBE in recent years, and it is gradually spreading to the world. This will be the first book summarizing from basic to advanced techniques with abundant illustrations and video aid for easy understanding.

Download or read book Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair written by Mario Barbosa and published by Woodhead Publishing. This book was released on 2017-09-25 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Download or read book Smart Nanomaterials for Biosensing and Therapy Applications volume II written by Qitong Huang and published by Frontiers Media SA. This book was released on 2024-04-29 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is Volume II of a series. The previous volume, which has attracted over 31k views can be found here: Smart Nanomaterials for Biosensing and Therapy Applications Medicine today faces several challenges when it comes to detecting diseases and prescribing effective treatments, which is crucial for successful disease diagnosis and treatment. Due to their unique structural and functional properties, nanomaterials, which have high surface areas and nanoscale sizes, are gaining wide attention and interest in bioengineering and biotechnology. Compared with bulk materials and molecular molecules, smart nanomaterials with special optical, magnetic, electrical and mechanical properties have shown great potential for biosensing and therapy applications. The development of these smart nanomaterials has created powerful and promising tools to address challenges in conventional diagnostic and therapeutic approaches, such as the lack of diagnostic accuracy and therapeutic efficiency. In the recent past, advances in smart nanomaterials and medical research have opened new possibilities for disease diagnosis and treatment.

Download or read book Advances in Tissue Engineering written by Julia Polak and published by World Scientific. This book was released on 2008-08-20 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field. Contents:Tissue Engineering: Past, Present and Future:An Introduction (R M Nerem)Cells for Tissue Engineering:A Brief Introduction to Different Cell Types (L Buttery & K M Shakesheff)Human Embryonic Stem Cells: International Policy and Regulation (M Allyse & S Minger)Human Embryonic Stem Cells: Derivation and Culture (E L Stephenson et al.)Stem Cells Differentiation (P V Guillot & W Cui)Marrow Stem Cells (D G Phinney)Cord Blood Stem Cells — Potentials and Realities (C P McGuckin & N Forraz)Fat Stem Cells (J M Gimble et al.)Control of Adult Stem Cell Function in Bioengineered Artificial Niches (M P Lutolf & H M Blau)Stem Cell Immunology (A P Hollander & D C Wraith)Development of a Design of Experiment Methodology: Applications to the Design and Analysis of Experiments (M Lim & A Mantalaris)Banking Stem Cell Lines for Future Therapies (G N Stacey & C J Hunt)Materials:Synthetic Biomaterials as Cell-Responsive Artificial Extracellular Matrices (M P Lutolf & J A Hubbell)Bioactive Composite Materials for Bone Tissue Engineering Scaffolds (S Verrier & A R Boccaccini)Aggregation of Cells Using Biomaterials and Bioreactors (Z Bayoussef & K M Shakesheff)Nanotechnology for Tissue Engineering (J S Stephens-Altus & J L West)Microscale Technologies for Tissue Engineering (A Khademhosseini et al.)Non-Invasive Methods to Monitor Tissue Re-Modelling: Biosensors(T Cass)Tissue-Engineering Monitoring Using Microdialysis (Z-H Li et al.)Characterisation of Tissue Engineering Constructs by Raman Spectroscopy and X-ray Micro-Computed Tomography (μCT) (I Notingher & J R Jones)Role of Stem Cell Imaging in Regenerative Medicine (G Passacquale & K Bhakoo)Biotechnology Sector:Lessons Learnt (N L Parenteau et al.)The Promise of Stem Cells: A Venture Capital Perspective (C Prescott)Tissue Engineering Products:Cell Expansion, Cell Encapsulation, 3D Cultures (J M Polak & A Mantalaris)Bioreactor Engineering: Regenerating the Dynamic Cell Microenvironment (T Dvir & S Cohen)UK Regulatory Issues: The View from the Researcher (C Munro & N Harris)Tissue Repair:Stem Cell Therapy: Past, Present, and Future (F Baron & R Storb)Tissue Engineered Skin Comes of Age? (S MacNeil)Liver Repair (N Levicar et al.)Tissue Engineering for Tooth Regeneration (I A Diakonov & P Sharpe)Urogenital Repair (A Atala)Cardiac Repair:Basic Science (S E Harding)Cardiac Repair Clinical Trials (A Green & E Alton)Myocardial Recovery Following LVAD Support (R S George & E J Birks)Osteoarticular Repair:Animal Models (E A Horner et al.)In Vitro 3D Human Tissue Models for Osteochondral Diseases (S Ghosh & D L Kaplan)Application of Tissue Engineering for Craniofacial Reconstruction (D M Gupta et al.)Clinical Trials (A K Haudenschild & M H Hedrick)Lung Repair:Tissue Engineering for the Respiratory Epithelium: Is There a Future for Stem Cell Therapy in the Lung? (V Besnard & J A Whitsett)The Artificial Lung (A N Maurer & G Matheis) Readership: Stem cell researchers, clinicians, surgeons and biotechnology companies. Keywords:Stem Cells;Tissue Engineering;Regenerative Medicine;BiomaterialsKey Features:Discusses in-depth a topical subject, treated with the very latest informationWritten by leading contributors in the field, with the world-renowned Professor Dame Julia Polak as the lead editorContains an array of color diagrams and illustrationsDiffers from competing titles in that its coverage ranges from the basic science of stem cells and biomaterials to clinical applications, policy issues, views from the commercial sector and many others

Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.