Download or read book Intervertebral Disc Regeneration written by Benjamin Gantenbein and published by Mdpi AG. This book was released on 2022-01-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.

Download or read book The Intervertebral Disc written by Irving M. Shapiro and published by Springer Science & Business Media. This book was released on 2013-09-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.

Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Springer Nature. This book was released on 2022-06-01 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration

Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration

Download or read book Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians written by Roger Haertl and published by Thieme. This book was released on 2017-06-30 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top Experts Share Clinical Insights on Biological Interventions for Spine-Related Disease Although there have been significant advancements in minimally invasive spinal surgery techniques in the last few decades, optimal outcomes for chronic low back pain remain elusive. A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss treatment strategies, research findings, and future developments. Throughout each chapter, renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience. Key Highlights The current state of the art in biological and tissue engineering procedures for spinal disorders Treatment methodologies including nucleus replacement and repair, annulus fibrosus repair, total disc transplantation, and mechanical total disc replacement Innovative treatment strategies for disc regeneration, such as genes and proteins Growth factors including platelet-rich plasma (PRP), which has shown promise for the stimulation and acceleration of bone and soft tissue healing Cell-based therapy for spinal disc regeneration and repair including the use of stem cells and chondrocytes In-depth discussion of research including animal versus human model, in-vitro, and a summary of biologic clinical trials This is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who treat patients for spine-related conditions. It is essential reading for all clinicians who have an interest in cutting-edge tissue engineering and biological treatment interventions.

Download or read book The Disc and Degenerative Disc Disease written by Luigi Manfrè and published by Springer Nature. This book was released on 2021-01-05 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This easy-to-consult guide examines the most advanced techniques in the radiological evaluation of the disc and degenerative disc disease, using conventional, functional, dynamic and advanced imaging. It provides clear information on a range of CT, X-ray, and MRI guided techniques, presents all disc treatments in connection with symptomatic disc herniations, evaluates conservative, chemical (ESI, steroid, Ozone, ethanol gel injections) and physical treatments (coblation, laser, decompressors, endoscopy), and assesses the possibility of repairing and/or regenerating the disc in the context of reversible disc degeneration. Like other books in the Springer series New Procedures in Spinal Interventional Neuroradiology, this practice-oriented volume will fill a significant gap in the literature and meet the need expressed by many specialists (interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists) for a topical and handy guide that specifically illustrates the currently available materials and methods.

Download or read book Mesenchymal Stem Cells written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-11-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.

Download or read book Arthroplasty of the Spine written by Robert Gunzburg and published by Springer Science & Business Media. This book was released on 2003-12-02 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joint replacement is a logical step in the treatment of severe joint pathologies with irreversible lesions resisting conservative therapy. At the spinal level, arthrodesis became, very early, the gold standard of treatment for severe intervertebral disc pathologies. The next logical step was to envision functional replacement, and this step was taken as early as 1956, when the first intervertebral implant was described. However, it took many more years and a great variety of proposed implant designs before clinical applications could be attempted.

Download or read book Current Techniques in Canine and Feline Neurosurgery written by Andy Shores and published by John Wiley & Sons. This book was released on 2017-08-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Techniques in Canine and Feline Neurosurgery offers state-of-the-art, detailed guidance on performing neurosurgical techniques in dogs and cats, from indications and surgical anatomy to procedures and post-operative care. Presents an up-to-date, detailed reference on veterinary neurosurgery techniques, covering skills ranging from basic to advanced Provides guidance on why, when, and how to perform neurosurgical procedures Includes information on diagnostic evaluation, surgical planning, and instrumentation as well as step-by-step descriptions of specific procedures Copublished with the American College of Veterinary Surgeons Foundation and American College of Veterinary Internal Medicine Offers video clips on a companion website

Download or read book Intervertebral Disc Regeneration II written by Benjamin Gantenbein and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Intervertebral Disc written by Anthony F. De Palma and published by Saunders Limited.. This book was released on 1970 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Tissue Engineering written by Julia Polak and published by World Scientific. This book was released on 2008-08-20 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field. Contents:Tissue Engineering: Past, Present and Future:An Introduction (R M Nerem)Cells for Tissue Engineering:A Brief Introduction to Different Cell Types (L Buttery & K M Shakesheff)Human Embryonic Stem Cells: International Policy and Regulation (M Allyse & S Minger)Human Embryonic Stem Cells: Derivation and Culture (E L Stephenson et al.)Stem Cells Differentiation (P V Guillot & W Cui)Marrow Stem Cells (D G Phinney)Cord Blood Stem Cells — Potentials and Realities (C P McGuckin & N Forraz)Fat Stem Cells (J M Gimble et al.)Control of Adult Stem Cell Function in Bioengineered Artificial Niches (M P Lutolf & H M Blau)Stem Cell Immunology (A P Hollander & D C Wraith)Development of a Design of Experiment Methodology: Applications to the Design and Analysis of Experiments (M Lim & A Mantalaris)Banking Stem Cell Lines for Future Therapies (G N Stacey & C J Hunt)Materials:Synthetic Biomaterials as Cell-Responsive Artificial Extracellular Matrices (M P Lutolf & J A Hubbell)Bioactive Composite Materials for Bone Tissue Engineering Scaffolds (S Verrier & A R Boccaccini)Aggregation of Cells Using Biomaterials and Bioreactors (Z Bayoussef & K M Shakesheff)Nanotechnology for Tissue Engineering (J S Stephens-Altus & J L West)Microscale Technologies for Tissue Engineering (A Khademhosseini et al.)Non-Invasive Methods to Monitor Tissue Re-Modelling: Biosensors(T Cass)Tissue-Engineering Monitoring Using Microdialysis (Z-H Li et al.)Characterisation of Tissue Engineering Constructs by Raman Spectroscopy and X-ray Micro-Computed Tomography (μCT) (I Notingher & J R Jones)Role of Stem Cell Imaging in Regenerative Medicine (G Passacquale & K Bhakoo)Biotechnology Sector:Lessons Learnt (N L Parenteau et al.)The Promise of Stem Cells: A Venture Capital Perspective (C Prescott)Tissue Engineering Products:Cell Expansion, Cell Encapsulation, 3D Cultures (J M Polak & A Mantalaris)Bioreactor Engineering: Regenerating the Dynamic Cell Microenvironment (T Dvir & S Cohen)UK Regulatory Issues: The View from the Researcher (C Munro & N Harris)Tissue Repair:Stem Cell Therapy: Past, Present, and Future (F Baron & R Storb)Tissue Engineered Skin Comes of Age? (S MacNeil)Liver Repair (N Levicar et al.)Tissue Engineering for Tooth Regeneration (I A Diakonov & P Sharpe)Urogenital Repair (A Atala)Cardiac Repair:Basic Science (S E Harding)Cardiac Repair Clinical Trials (A Green & E Alton)Myocardial Recovery Following LVAD Support (R S George & E J Birks)Osteoarticular Repair:Animal Models (E A Horner et al.)In Vitro 3D Human Tissue Models for Osteochondral Diseases (S Ghosh & D L Kaplan)Application of Tissue Engineering for Craniofacial Reconstruction (D M Gupta et al.)Clinical Trials (A K Haudenschild & M H Hedrick)Lung Repair:Tissue Engineering for the Respiratory Epithelium: Is There a Future for Stem Cell Therapy in the Lung? (V Besnard & J A Whitsett)The Artificial Lung (A N Maurer & G Matheis) Readership: Stem cell researchers, clinicians, surgeons and biotechnology companies. Keywords:Stem Cells;Tissue Engineering;Regenerative Medicine;BiomaterialsKey Features:Discusses in-depth a topical subject, treated with the very latest informationWritten by leading contributors in the field, with the world-renowned Professor Dame Julia Polak as the lead editorContains an array of color diagrams and illustrationsDiffers from competing titles in that its coverage ranges from the basic science of stem cells and biomaterials to clinical applications, policy issues, views from the commercial sector and many others

Download or read book The Biology of the Intervertebral Disc written by Peter Ghosh and published by . This book was released on 1988 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Spine Technology written by Boyle C. Cheng and published by Springer. This book was released on 2021-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the most authoritative and up-to-date reference on spine technology written for practitioners, researchers, and students in bioengineering and clinical medicine. It is the first resource to provide a road map of both the history of the field and its future by documenting the poor clinical outcomes and failed spinal implants that contributed to problematic patient outcomes, as well as the technologies that are currently leading the way towards positive clinical outcomes. The contributors are leading authorities in the fields of engineering and clinical medicine and represent academia, industry, and international government and regulatory agencies. The chapters are split into five sections, with the first addressing clinical issues such as anatomy, pathology, oncology, trauma, diagnosis, and imaging studies. The second section, on biomechanics, delves into fixation devices, the bone implant interface, total disc replacements, injury mechanics, and more. The last three sections, on technology, are divided into materials, commercialized products, and surgery. All appropriate chapters will be continually updated and available on the publisher’s website, in order to keep this important reference as up-to-date as possible in a fast-moving field.

Download or read book Mechanical Properties of Aging Soft Tissues written by Brian Derby and published by Springer. This book was released on 2014-10-08 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the structure and mechanics of aging soft tissues, this edited volume presents authoritative reviews from leading experts on a range of tissues including skin, tendons, vasculature and plantar soft tissues. It provides an overview of in vivo and in vitro measurement techniques including state-of-the-art methodologies, as well as focusing on the structural changes that occur within the main components of these tissues resulting in detrimental mechanical property changes. It also highlights the current challenges of this field, and offers an insight into future developments. Age-related changes in the mechanical properties of soft tissues have a profound effect on human morbidity and mortality, and with changing global demographics, there is growing interest in this area. There has been increasing interest in robustly characterizing these mechanical changes to develop structure-property relationships, and growing awareness of the need for enhanced predictive models for computational simulations. This book seeks to address the challenges involved in applying these engineering techniques to reliably characterize these tissues. Focusing on a wide range of tissues and presenting cutting-edge techniques, this book provides an invaluable reference to academics and researchers in a range of disciplines including biomechanics, materials science, tissue engineering, life sciences and biomedicine.

Download or read book Lumbar Intervertebral Disc Degeneration an Issue of Orthopedic Clinics written by Dino Samartzis and published by W B Saunders Company. This book was released on 2011 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Lumbar Intervertebral Disc Degeneration, Structure and Biology of the Intervertebral Disc in Health and Disease, Nutrition of the Intervertebral Disc, The Endplate and Its Relevance with Intervertebral Disc Degeneration, Genetic Risk Factors in Intervertebral Disc Degeneration, Biomechanics of Intervertebral Disc Degeneration, Diagnostic Tools and Imaging Methods in Intervertebral Disc Degeneration, An Overview of the Management of Degenerative Disc Disease, Adjacent Level Disc Disease - Is it Really a Fusion Disease? Prosthetic Total Disc Replacement, Stem Cell Regeneration of the Intervertebral Disc, Gene Therapy for Intervertebral Disc Degeneration, Tissue Engineering for Intervertebral Disc Degeneration, Emerging Technologies for Molecular Therapy for Intervertebral Disc Degeneration, Intervertebral Disc Transplantation

Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.