Download or read book Interferon Induced Thrombotic Microangiopathy written by Ajay Kundra and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon (IFN) is an effective therapy for multiple disorders. An infrequently reported side effect is thrombotic microangiopathy (TMA): thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). We published the first comprehensive review analyzing this association with the following observations: (1) there was a higher incidence of IFN-induced TMA in myeloproliferative disorders (chronic myelogenous leukemia (CML)) than that in nonmalignant disorders (multiple sclerosis (MS), chronic hepatitis C virus infection (HCV)); (2) mean age at diagnosis was 47 years; (3) there was rare association with hairy cell leukemia (HCL), Sezary syndrome (one case each) and no cases reported for polycythemia vera (PV); (4) sex distribution was balanced (exception of higher prevalence in females for MS); (5) TMA was insidious in onset with long incubation periods (average treatment duration 40.4 months); (6) comparative analysis of mean time (months) to onset of TMA ensuing cumulative IFN exposure was: MS 68.6 vs. CML 35.5 vs. HCV 30.4; (7) confirmed TTP (low ADAMTS 13 levels) was associated with the presence of an inhibitor; (8) outcome analysis revealed complete remission in 27 (40%), persistent chronic kidney disease in 28 (42%) and fatality in 12 patients (18%); (9) corticosteroids, plasma exchange (PEX) and rituximab are effective therapies.
Download or read book Thrombotic Thrombocytopenic Purpura hemolytic Uremic Syndrome in Relapsing remitting Multiple Sclerosis Patients on High dose Interferon written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Three women aged 34–47 years old, on high dose interferon beta-1a for relapsing–remitting multiple sclerosis, were hospitalized between 2009–2012 for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Patients sought medical attention for neurological symptoms including cephalalgia, blurred vision, confusion, focal deficits and seizures. All patients presented thrombocytopenia, hemolytic anemia and arterial hypertension. Despite plasma exchanges, corticosteroids and anti-CD20 treatments, all patients progressed towards severe renal insufficiency and one patient died of hemorrhagic shock. In this report we identify a rare but morbid complication of interferon beta-1a treatment associated with female gender, Caucasian background and low body mass index.
Download or read book Thrombocytopenia written by Pankaj Abrol and published by . This book was released on 2018 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book ""Thrombocytopenia"" certainly raises some important issues in its pathogenesis and management. The authors have done a lot of hard work to write state-of-the-art chapters. Each and every chapter is peer-reviewed, evidence-based, and remarkably excellent. Some of the causes of thrombocytopenia are well explained in textbooks, but the topics included in this book are not usually so well described. The chapters are written in such a manner so as to stimulate and keep the reader well-informed. Such an approach is certainly beneficial when aiming to motivate discussion, interaction, innovation, and research. Chapters like ""Interferon-Induced Thrombotic Microangiopathy"" have been included with the aim to help in understanding the immune pathogenesis of thrombocytopenia. Others have also been selected to keep an eye on the future.
Download or read book Meyler s Side Effects of Antimicrobial Drugs written by Jeffrey K. Aronson and published by Elsevier. This book was released on 2009-11-27 with total page 3064 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elsevier now offers a series of derivative works based on the acclaimed Meyler’s Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician. This volume is essential for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses. The only drug guide that includes clinical case studies and expert analysis UNIQUE! Features not only antimicrobial drugs, but also all other drugs that act in an anti-microbial manner Most complete cross referencing of drug-drug interactions available Latest content from the most highly regarded compilation of drug side effects: Side Effects of Drugs Annual serial
Download or read book Thrombotic Microangiopathies Diagnostic and Therapeutic Advances written by Robert W. Maitta and published by Frontiers Media SA. This book was released on 2022-01-19 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Meyler s Side Effects of Drugs 15E written by Jeffrey K. Aronson and published by Newnes. This book was released on 2014-04-11 with total page 4204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary or pharmaceutical company. Now available online for all academic, corporate or government institution as well as individuals viaScience Direct! The online version provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organised alphabetically Completely expanded coverage of each drug - thalidomide warranted three sentences in Meyler's 14th edition, but is now a 13 page extensive monograph Clearer, systematic organization of information for easier reading including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references - Meyler's 15th edition incorporates all relevant citations from Meyler's 14th, but also includes relevant citations from previous editions of Meyler's and Side Effects of Drugs Annuals to give a historical perspective on the use and safety of drugs
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Download or read book Thrombocytopenia written by Pankaj Abrol and published by BoD – Books on Demand. This book was released on 2018-03-07 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Thrombocytopenia" certainly raises some important issues in its pathogenesis and management. The authors have done a lot of hard work to write state-of-the-art chapters. Each and every chapter is peer-reviewed, evidence-based, and remarkably excellent. Some of the causes of thrombocytopenia are well explained in textbooks, but the topics included in this book are not usually so well described. The chapters are written in such a manner so as to stimulate and keep the reader well-informed. Such an approach is certainly beneficial when aiming to motivate discussion, interaction, innovation, and research. Chapters like "Interferon-Induced Thrombotic Microangiopathy" have been included with the aim to help in understanding the immune pathogenesis of thrombocytopenia. Others have also been selected to keep an eye on the future.
Download or read book Glomerulonephritis written by Howard Trachtman and published by Springer. This book was released on 2019-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as a convenient, state-of-the-art and comprehensive resource on the pathogenesis, diagnosis, and treatment of glomerular diseases. Clinical approaches, modalities and challenges are provided, along with new developments since the publication of Kidney Disease Improving Global Outcomes (KDIGO): Glomerulonephritis. Chapters dedicated to glomerular diseases mirror the current classification schemes used by Nephrologists and Pathologists and will include definition and natural history, epidemiology, clinical manifestations, pathology, diagnosis, differential diagnosis, treatment (algorithms when appropriate), prognosis and future prospects and current direction of research. Contributing authors consist of internationally renowned glomerulonephritis experts, renal pathologists and clinical nephrologists who are engaged in the management of glomerular diseases in clinical pediatric and internal medicine practices. Glomerulonephritis fills a considerable knowledge gap for general nephrologists, providers involved with the care of patients with glomerular diseases, and researchers. It should also be of value to medical students, interns, residents and fellows, as well as all clinicians engaged in medical education.
Download or read book Heptinstall s Pathology of the Kidney written by J. Charles Jennette and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts in the field of renal disease offer careful pathologic descriptions, appropriate clinical correlations, and extensive discussions on causes and pathogenesis to clarify the clinicians understanding and help facilitate easy, accurate diagnosis. This updated edition features hundreds of razor-sharp illustrations along with more international contributors than before.
Download or read book Meyler s Side Effects of Drugs written by Jeffrey K. Aronson and published by Elsevier. This book was released on 2015-10-15 with total page 7629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company
Download or read book Interferons written by Carlo Aul and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.
Download or read book Textbook of Therapeutics written by Richard A. Helms and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 2773 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributors to this volume deliver information on latest drug treatments and therapeutic approaches for a wide range of diseases and conditions. Coverage includes discussion of racial, ethnic, and gender differences in response to drugs and to biotechnical, pediatric and neonatal therapies.
Download or read book Principles and Practice of Transplant Infectious Diseases written by Amar Safdar and published by Springer. This book was released on 2019-06-13 with total page 1173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume provides a platform from which both major and minor infectious diseases related issues are addressed in-depth among this highly susceptible population. The book begins with an overview of infections in various modalities. This is followed by chapters on clinical disorders, etiologic agents, therapeutics, and infection prevention. Chapters include easy-to-follow figures and tables, radiologic images, and pictorial demonstrations of various disease states to familiarize and reacquaint the transplant clinicians and surgeons in practice and training, and those belonging to subspecialties providing supportive care for these patients. Discussions to enumerate the noninfectious causes that mimic infectious diseases; clinical relevance and effective utility of existing and emerging diagnostic tools are presented throughout the book. Authored by leaders in their fields, this book is the go-to reference for management of patients undergoing hematopoietic and solid organ transplantation.
Download or read book Onco Nephrology E Book written by Kevin W. Finkel and published by Elsevier Health Sciences. This book was released on 2019-07-02 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects. Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice.
Download or read book Meyler s Side Effects of Drugs in Cancer and Immunology written by Jeffrey K. Aronson and published by Elsevier. This book was released on 2010-04-19 with total page 1963 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elsevier now offers a series of derivative works based on the acclaimed Meyler’s Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician. There has been significant progress in the development of targeted therapy drugs that act specifically on certain cancers, and that minimize damage to normal cells. Oncologists and cancer researchers will rely on this volume to determine effective drug treatments. The only drug guide that includes clinical case studies and expert analysis UNIQUE! Features not only anticancer drugs, but also all other drugs that act upon related organ systems affected by cancer Most complete cross referencing of drug-drug interactions available Latest content from the most highly regarded compilation of drug side effects: Side Effects of Drugs Annual serial
Download or read book Brenner and Rector s The Kidney E Book written by Karl Skorecki and published by Elsevier Health Sciences. This book was released on 2019-09-25 with total page 2748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Put the world’s most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector’s The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. Discussions of today’s hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zürich. Board review-style questions to help you prepare for certification or recertification.
