Download or read book Interaction Between Chikungunya and Dengue Viruses During Co infection in Aedes Mosquito Cells and in Aedes Aegypti Mosquito written by Margot Enguehard and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emergence and geographical extension of dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses increase simultaneous outbreak in an increasing number of countries. To date, no vaccine or cure have yet been developed against these diseases those cause a tremendous impact on human health and in the economy worldwide. During recent simultaneous outbreaks, up to 12% of patients have been diagnosed to be co-infected by CHIKV and DENV. In addition, it was shown that the mosquitoes Aedes albopictus could carry and transmit simultaneously CHIKV and DENV. However, the pathology, as well as the epidemiology of a pathogen, relies on the interactions between several infectious agents present within an organism or a community in the environment. It is crucial to consider to which extent a host infected by a first microorganism is modified and whether its reaction to the infection by a second microorganism is consequently altered. However, there is no extensive report of Alphavirus-Flavivirus or Flavivirus- Flavivirus interactions. Our global objective is to characterize these co-infections in both mosquitoes and humans, at the cell and molecular level. To this aim, we started this project by performing sequential co- infection in different cell lines from Aedes albopictus and Aedes aegypti. We found that the permissiveness and production of DENV is enhanced in presence of CHIKV. On the contrary, there is no effect of DENV pre-infection on subsequent CHIKV co-infection. We generalized the synergistic phenomena and we showed that CHIKV pre-infection also increased the infection by DENV-1, DENV-3 and DENV-4, but also by two others re-emerging Flaviviruses, the Yellow Fever Virus (YFV), and the Zika Virus (ZIKV). Remarkably, we succeeded to establish a mosquito model of co-infection of Aedes aegypti mosquito after by different two feedings at 4 days interval. Using this sequential co-infection, we were able to show that a pre-infection of Aedes aegypti by CHIKV increase the level of DENV-2 RNA in salivary glands compare to mono-infected mosquitos. This phenotype is reminiscent of the phenotype we observed in vitro during successive infections. Altogether, our study paves the way to the characterization of molecular interaction between Flaviviruses and Alphaviruses in mosquito in vitro and in vivo. This study can be crucial for a better understanding of disease and epidemiology during simultaneous outbreaks.
Download or read book Current Topics in Chikungunya written by Alfonso J. Rodriguez-Morales and published by BoD – Books on Demand. This book was released on 2016-08-24 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chikungunya, an arbovirus, is a major global threat affecting multiple areas of the world, even Europe, but recently (2014 - 2015) with large epidemics in Latin America, causing an important acute and chronic morbidity with a low, but present, mortality. This book tries to update the significant epidemiological and clinical research in many aspects with a multinational perspective. This book has been organized in two major sections: (I) ''Clinical and Epidemiological Aspects'' and (II) ''Entomology.'' Section I includes topics covering experiences and studies in different countries, including the infection during pregnancy and children, imported cases, ocular manifestations, coinfections, and therapeutics. Section II includes topics on entomological aspects, related to vector control, and new options for biological control of Aedes aegypti.
Download or read book Biology of Disease Vectors written by William H. Marquardt and published by Elsevier. This book was released on 2004-12-04 with total page 811 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Disease Vectors presents a comprehensive and advanced discussion of disease vectors and what the future may hold for their control. This edition examines the control of disease vectors through topics such as general biological requirements of vectors, epidemiology, physiology and molecular biology, genetics, principles of control and insecticide resistance. Methods of maintaining vectors in the laboratory are also described in detail.No other single volume includes both basic information on vectors, as well as chapters on cutting-edge topics, authored by the leading experts in the field. The first edition of Biology of Disease Vectors was a landmark text, and this edition promises to have even more impact as a reference for current thought and techniques in vector biology.Current - each chapter represents the present state of knowledge in the subject areaAuthoritative - authors include leading researchers in the fieldComplete - provides both independent investigator and the student with a single reference volume which adopts an explicitly evolutionary viewpoint throuoghout all chapters. Useful - conceptual frameworks for all subject areas include crucial information needed for application to difficult problems of controlling vector-borne diseases
Download or read book Dengue written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.
Download or read book Emerging Viral Diseases of Southeast Asia written by Sunil K. Lal and published by Karger Medical and Scientific Publishers. This book was released on 2007 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts discuss the threat posed by emerging viruses and describe ongoing efforts to face future outbreaks by searching for new antivirals, developing new vaccines, and improving methods of diagnosis and surveillance. Australian contributor.
Download or read book Dengue and Zika Control and Antiviral Treatment Strategies written by Rolf Hilgenfeld and published by Springer. This book was released on 2018-05-29 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.
Download or read book The Togaviridae and Flaviviridae written by Sondra Schlesinger and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep lication strategies of these viruses are now known to be sufficiently di verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic ularly with regard to the cotranslational and posttranslational steps re quired for the synthesis and localization of membrane glycoproteins. Fur thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir idae and Flaviviridae are known, but important questions remain.
Download or read book Three Way Interactions Between Wolbachia Dengue Virus and Their Host Aedes Aegypti written by Andrew Pike and published by . This book was released on 2010 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chikungunya Virus written by Chioma M. Okeoma and published by Springer. This book was released on 2016-12-01 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the molecular biology, pathogenesis, epidemiology, and potential strategies for control of chikungunya virus (CHIKV) infection. It offers insight into the structure and functions of CHIKV proteins as they relate to host response, interaction with the arthropod vector, and vaccination. A detailed account of both the epidemiological outlook and the clinical syndrome of CHIKV infection is provided. The complex host-virus interaction and the signaling pathways that mediate such interactions are also covered. Throughout the book, graphics and charts are used to provide stimulating discussion on important findings in the field of chikungunyalogy. The chapters are written with a global perspective by experts of CHIKV from around the world. This project is especially significant given that CHIKV is a pathogen of worldwide public health concern. Although the presence of CHIKV infection is not global yet, worldwide dissemination is predicted in the future due largely to the lack of effective treatment/therapy, efficient control of transmission, and knowledge about mechanisms of pathogenesis. Additionally, globalization of CHIKV is predicated on its mode of dissemination (mosquito vector) and cross border travel and migration.
Download or read book Viruses written by Paula Tennant and published by Academic Press. This book was released on 2018-03-12 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived 'interactomics' as defined by the molecules and the processes by which virus gene products interact with themselves and their host's cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses - Provides key insights into recent technological advances, including high-throughput sequencing - Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life - Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions
Download or read book Chikungunya and Zika Viruses written by Stephen Higgs and published by Academic Press. This book was released on 2018-05-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chikungunya and Zika Viruses: Global Emerging Health Threats is the go-to resource for both historical and current information on this important virus that is rapidly increasing its global range. Epidemics since 2005 have spread from Africa and Asia, and through Europe, and an ongoing epidemic has caused nearly two million cases in the Americas. It causes severe crippling arthritis, with symptoms lasting for months or years. As no vaccine or treatment is available, there is international interest in the virus, thus funding opportunities for research have dramatically increased. This book presents our understanding of the virus, bringing comprehensive knowledge in a single source. - Provides a comprehensive collection of the state-of-the-art on CHIKV biology in a go-to reference book - Edited by leaders in the field who provide a single, up-to-date source of information - Gives a better understanding of the transmission and spread of chikungunya virus, a clear, coherent description of the outcomes of infection (both acute and chronic), and its biology and risk factors - Pulls relevant background information to justify projects of many professionals developing vaccines and mosquito vector control approaches
Download or read book The Effect of Dengue and Chikungunya Virus Mixed Infection in Aedes Albopictus C6 36 Cells Line and Aedes Spp Mosquitoes written by Rutcharin Potiwat and published by . This book was released on 2010 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aedes aegypti and Aedes albopictus are an important mosquito’s vector disease that supported dengue and chikungunya virus transmission in Asia and South East Asia countries. In recently, Ae. albopictus has a trend to displace to Ae. aegypti habitat in Africa, Europe and America, and Ae. albopictus is a great mainly vectors which contribute to mutant chikungunya virus transmission than Ae. aegypti, A226V substitute on E1 gene. All 4 serotype of dengue viruses are widely spread in Thailand annually which presents cocirculation in the same region. Additionally, reemergence of chikungunya outbreaks are reported in southern parts of Thailand in 2009, more than 24,029 cases of chikungunya fever have been reported. Although dual infections of two viruses in sera’s patient was reported but mixed infection in mosquito vector have been rarely studied. To evaluate whether both virus can be transmitted to human host by passing through single mosquito. We used Aedes albopictus C6/36 cell line and female Aedes spp. mosquitoes as a model of viral transmission in vitro and in vivo, respectively. The results show mixed-infection in C6/36 cell line and viral production are increase. Competitive suppression was found in two mosquitoes with using high viral concentration or equal titer and surprisingly, Ae. aegypti are supposed to carrying two viruses particle in single mosquitoes whereas Ae. albopictus presents only one strain of viral mixed-infection. The results provided the new knowledge in order to understand the effect of vector-virus interactions and virus transmission which might be applies to predict the outbreak and control the diseases in future.
Download or read book Pictorial Keys for the Identification of Mosquitoes Diptera Culicidae Associated with Dengue Virus Transmission written by L. M. Rueda and published by . This book was released on 2004-01-01 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mosquitoes written by Norbert Becker and published by Springer Nature. This book was released on 2020-09-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Mosquitoes – Identification, Ecology and Control” presents a wealth of information on the bionomics, systematics, ecology, research techniques and control of both nuisance and disease vector mosquitoes. It provides practical guidance and important information in an easily readable style, suitable for anyone involved with, or interested in mosquitoes and their management. In this new edition, 102 European species including the most important invasive species and more than 100 globally important vector and nuisance species are described. Most of them, including all European species, are presented in the fully illustrated identification keys, followed by a detailed description of the morphology, biology, distribution and medical importance of each species, including over 700 detailed drawings. “Mosquitoes – Identification, Ecology and Control” includes: · systematics and biology · medical significance · research techniques · morphological characteristics used for identification of larvae and adults · illustrated identification keys for larval and adult mosquito genera · morphology, ecology, and distribution of the species identified in the keys · biological, genetic, physical and chemical control of mosquitoes “Mosquitoes – Identification, Ecology and Control” is a valuable tool for vector ecologists, medical entomologists, students and all those involved with mosquito systematics, biology, ecology, and control world-wide. Society as a whole benefit from the implementation of carefully designed and sustainable programs for the management of mosquitoes, and the diseases they transmit. The third edition of this successful publication has been comprehensively updated and expanded, to provide the foundation of a more enlightened and informed approach to mosquito management.
Download or read book Dengue and Dengue Hemorrhagic Fever 2nd Edition written by Duane J. Gubler and published by CABI. This book was released on 2014-08-29 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. Recent exciting research on dengue has resulted in major advances in our understanding of all aspects of the biology of these viruses, and this updated second edition brings together leading research and clinical scientists to review dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and clinical management.
Download or read book Chikungunya Virus written by and published by BoD – Books on Demand. This book was released on 2022-02-09 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chikungunya virus (CHIKV) is an RNA virus that is transmitted to humans by Aedes mosquitos commonly found in tropical and subtropical countries. In humans, CHIKV causes an infection with symptoms strikingly like those of the dengue virus and Zika disease, both of which are also transmitted to humans by the same genus of mosquitos. This book delves into the history of the disease and the molecular characterization of the virus. It sheds light on modern diagnosis tools that allow unambiguous identification of CHIKV infection. In addition, this book addresses the epidemiology of chikungunya fever, the distribution and spread of the disease, and the promising approaches under consideration for preventing and treating the disease.
Download or read book Host Pathogen Interactions During Arboviral Infections written by Alan G. Goodman and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arboviruses, or arthropod-borne viruses, such as West Nile virus, Dengue virus, and Zika virus, pose a serious threat to public health worldwide. West Nile virus was introduced to the United States in 1999, and is now endemic, causing over 2,000 domestically acquired cases in the U.S. annually in mammals. Similarly, dengue and Zika viruses are endemic in the Americas and pose novel threats to the human population. Tick-borne viruses such as Powassan virus and Heartland virus are increasing in frequency in the U.S. At this time, there is no commercially available vaccine or therapeutic to treat these viral infections. Because nearly every mammalian case of these virus infections originates from the insect vector, it is imperative that we also understand viral pathogenesis, transmission, and the immune response in insect models as well as pathogenesis and the host responses in infected mammals. The development of methods to block arbovirus transmission from the vector may be effective at ceasing arthropod-to-human infection since the current recommendation to prevent these viral infections is to decrease contact with mosquitoes. Additionally, improving our understanding of epidemiology and ecology will also help develop measures to reduce virus spread. In order to better study mammalian and insect host responses to infection, a number of genetic tools are available, such as fly, mosquito, and tick models, recombinant viruses, mouse models, and bioinformatics tools. The studies described in this eBook will illustrate host responses to infection using mammalian and insect models, identify critical signaling nodes of the innate immune response, and discuss virus transmission from insect to mammal or among infected hosts. Taken together, these studies will elucidate means of decreasing infections in human populations and provide potential targets for future study and therapeutic design.
