Download or read book Integrin Mediated Signaling in Prostate Cancer Role of KAI1 CD82 in Regulating Integrin and Androgen Receptor Function During Metastasis written by and published by . This book was released on 2007 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: How prostate tumors become metastatic is virtually unknown. A prostate metastasis suppressor gene, KAI1/CD82, known to associate with laminin receptors, allowed us to test the hypothesis that loss of KAI1/CD82 expression alters the function of laminin integrins in prostate cancer cells, resulting in altered intracellular signaling and increased invasion leading to metastasis. We have demonstrated that in metastatic tumor cells, where elevated c-Met expression and activation by integrins is responsible for enhancing laminin-dependent migration and invasion, re-expression of CD82 suppresses, while loss of CD82 enhances c-Met activation. Orthotopic injection of CD82-expressing metastatic cells into mouse prostates suppresses both metastasis and growth in vivo. CD82 appears to regulate c-Met activation by altering the distribution of c-Met on the cell surface, possibly through CD82 association with another tetraspanin, CD9, and their joint association with PI integrin. Our studies have advanced the knowledge of how members of the tetraspanin family function and are potentially applicable to all metastatic disease, since KAI1/CD82 loss has been reported in many types of cancers. Our results suggest that targeting c-Met would be a logical approach to therapeutic intervention of metastatic disease. Our findings further suggest that together CD82 expression and c-Met activation could be used as a potential biomarker pair for the prediction of metastatic disease. In addition we have shown that the PI-3K/Akt pathway is critical for laminin-specific survival in metastatic prostate cells, but activation of the androgen receptor (AR) by-passes the need for PI-3K signaling when cells are adherent to laminin. Since over 90% of metastatic prostate cancers still express AR, targeting the PI-3K pathway alone would not be sufficient to kill tumors in a laminin-rich environment.
Download or read book Integrin mediated Effects on Androgen Receptor Activity in Prostate Cancer Development Using a Prostate Cancer Model System written by Kerry Ann Crockett and published by . This book was released on 2005 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Androgen Receptor and Integrin Regulation of Prostate Epithelial Differentiation and Tumor Cell Survival written by Laura Elaine Lamb and published by . This book was released on 2010 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Integrin Regulated Jinase PYK 2 A Therapeutic Target for Prostate Cancer written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prostate cancer cell's growth differentiation and survival are guided by its interactions with the surrounding extracellular matrix (ECM). A number of promising therapeutic targets for androgen-independent and metastatic prostate cancers are contained within the signaling cascades downstream of the ECM-binding Integrin molecules. My research focuses on one component of these cascades, the phosphotyrosine kinase PYK-2, whose expression levels and activity I aim to manipulate in cell culture and within tumors in mice, using constitutively-active and dominant-negative PYK-2 constructs under the control of tetracycline-inducible promoters. Such regulation of PYK-2 may provide a means of pushing cells forward or backward in cancerous progression. By monitoring changes in the behaviors of cells expressing PYK-2 mutant variants, in the presence and absence of integrin-stimulating and blocking factors, we are simultaneously studying the downstream role of PYK-2 in regulating cell behaviors, and the upstream role of integrins in regulating PYK-2. Finally, we will introduce the PYK- 2-construct-expressing cells into adult mice, that we treat with tetracycline at different times during tumor development, castrate or leave whole, and monitor for tumor progression and necrosis. An extremely valuable tool in these studies will be the lineage- related LNCaP cell lines, developed in our laboratory, each of which represents a stage in prostate cancer cell progression, from marginally-tumorigenic and androgen-sensitive, to highly-metastatic and androgen- insensitive. If intentional PYK-2 modulation proves sufficient to control LNCaP model cell proliferative, migratory or apoptotic behaviors, our laboratory is uniquely equipped to develop the approach into a clinical therapy, by delivering the genes in an adenoviral vector, first to LNCaP tumors in mice, and eventually to men.
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Non receptor Tyrosine Kinases in Prostate Cancer written by Yu-Ming Chang and published by . This book was released on 2008 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Research written by and published by . This book was released on 2007-02 with total page 1086 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exosomes written by Lawrence R. Edelstein and published by Academic Press. This book was released on 2019-10-16 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. - Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. - Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts - Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Download or read book Introduction to Cancer Metastasis written by Aamir Ahmad and published by Academic Press. This book was released on 2016-11-14 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. - Includes basic biology and translational approaches to organ-specific cancer sites - Provides readers with information on emerging therapeutic targets for cancer metastasis - Contains contributions from leading researchers around the globe
Download or read book Tetraspanins written by Fedor Berditchevski and published by Springer Science & Business Media. This book was released on 2013-03-20 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.
Download or read book GPCR Signaling in Cancer written by and published by Academic Press. This book was released on 2020-03-06 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics. Covers the latest concepts in GPCR signaling and their relevancy to cancer biology Presents new indications for anti-cancer therapeutic programs Includes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics
Download or read book Effectiveness of Tax and Price Policies for Tobacco Control written by IARC Working Group on the Effectiveness of Tax and Price Policies for Tobacco Control and published by . This book was released on 2011 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of the IARC Handbooks of Cancer Prevention in Tobacco Control presents a critical review and evaluation of the evidence by 25 international experts from twelve countries on the economics, epidemiology, public policy and tobacco control aspects of tax and price policies. The working group draws conclusions about the effectiveness of tax and price measures to control tobacco use in the population. The Handbook covers an overview of tobacco taxation; industry pricing strategies and other industry initiatives diluting the effects of taxes on consumption; tax, price and aggregated demand for tobacco, as well as demand at the individual level in adults, young people and the economically disadvantaged; tax avoidance and tax evasion and the economic and health impacts of tobacco taxation. This body of evidence and the consensus evaluation of 18 concluding statements on the impact of interventions to increase the price of tobacco products, can assist policy makers, government officials, evaluators and researchers working in tobacco control and disease prevention, to base their decisions on the latest scientific evidence.
Download or read book Basic and Applied Bone Biology written by David B. Burr and published by Academic Press. This book was released on 2013-06-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. - Presents an in-depth overview of skeletal biology from the molecular to the organ level - Offers "refresher" level content for clinicians or researchers outside their areas of expertise - Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology
Download or read book Cancer Metastasis Related Genes written by D.R. Welch and published by Springer Science & Business Media. This book was released on 2002-07-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,
Download or read book The Molecular Biology of Cadherins written by and published by Academic Press. This book was released on 2013-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field.
