Download or read book Integrating Emerging Technologies Into Chemical Safety Assessment written by Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides and published by . This book was released on 2012-01 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrating Emerging Technologies Into Chemical Safety Assessment written by The Expert Panel on the Integrated Testing of Pesticides and published by Council of CanadianAcademies. This book was released on 2012 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In May 2009, the Government of Canada, through the Pest Management Regulatory Agency (PMRA) of Health Canada, asked the Council of Canadian Academies to appoint an expert panel to answer the question, "What is the scientific status of the use of integrated testing strategies in the human and environmental regulatory risk assessment of pesticides?" The charge to the Panel was further specified in a series of sub-questions: [1] What is the state of the science of the tools and data sources associated with integrated testing strategies? [2] What is the current status of the use of integrated testing strategies for the risk assessment of pesticides, pharmaceuticals, industrial chemicals, and other chemical substances by regulatory agencies around the world? [3] Could there be potential impacts on the public's perception and confidence in regulatory risk assessment and risk management decisions for pesticides if integrated testing strategies were implemented?"--P. xiii-xiv.
Download or read book Chemical Testing Using New Approach Methodologies NAMs written by Amy J. Clippinger and published by Frontiers Media SA. This book was released on 2022-12-16 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Download or read book Guidelines for Integrating Process Safety Management Environment Safety Health and Quality written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2010-09-07 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, companies have developed independent systems for managing process safety, environment, health, safety, and quality. Many aspects of these management systems are similar. Integrating EHS management systems can yield economies and improved system effectiveness. This book explains how integration reduces cost of delivery through a reduction in the number of management program steps and avoidance of redundancy; how it results in more effective programs, since the best practices can be combined into a single process; and how this integration brings a faster, and more cost effective response to new demands.
Download or read book Validation of Alternative Methods for Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2016-09-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Download or read book Applications of Toxicogenomics in Safety Evaluation and Risk Assessment written by Darrell R. Boverhof and published by John Wiley & Sons. This book was released on 2011-10-11 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Download or read book Safety Assessment for Chemical Processes written by Jörg Steinbach and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of the good safety records of chemical plants many people regard chemical production as dangerous because of a few major accidents that have occurred. A knowledge of at least the fundamentals of chemical safety technology is indispensable for chemists and engineers working in chemical industry. The increasingly stringent legal and administrative requirements can only be answered by more highly qualified employees. This book combines the author's experience of 15 years of research in the field of chemical safety and 10 years in the chemical industry. It provides newcomers with an easy access to the field and helps practitioners in the chemical industry to answer all questions concerning their daily work with hazardous materials or potentially dangerous chemical plants. The investigation of risks, and preventive measures to be taken to minimize the probability of an accident, as well as its consequences are explained.
Download or read book Safe Science written by National Research Council and published by National Academies Press. This book was released on 2014-10-08 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent serious and sometimes fatal accidents in chemical research laboratories at United States universities have driven government agencies, professional societies, industries, and universities themselves to examine the culture of safety in research laboratories. These incidents have triggered a broader discussion of how serious incidents can be prevented in the future and how best to train researchers and emergency personnel to respond appropriately when incidents do occur. As the priority placed on safety increases, many institutions have expressed a desire to go beyond simple compliance with regulations to work toward fostering a strong, positive safety culture: affirming a constant commitment to safety throughout their institutions, while integrating safety as an essential element in the daily work of laboratory researchers. Safe Science takes on this challenge. This report examines the culture of safety in research institutions and makes recommendations for university leadership, laboratory researchers, and environmental health and safety professionals to support safety as a core value of their institutions. The report discusses ways to fulfill that commitment through prioritizing funding for safety equipment and training, as well as making safety an ongoing operational priority. A strong, positive safety culture arises not because of a set of rules but because of a constant commitment to safety throughout an organization. Such a culture supports the free exchange of safety information, emphasizes learning and improvement, and assigns greater importance to solving problems than to placing blame. High importance is assigned to safety at all times, not just when it is convenient or does not threaten personal or institutional productivity goals. Safe Science will be a guide to make the changes needed at all levels to protect students, researchers, and staff.
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Download or read book Toxicogenomics in Predictive Carcinogenicity written by Michael D. Waters and published by Royal Society of Chemistry. This book was released on 2016 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.
Download or read book Biomarkers of Exposure Effect and Susceptibility to Environmental and Occupational Chemicals written by Manosij Ghosh and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Green Chemistry and Engineering written by Anne E. Marteel-Parrish and published by John Wiley & Sons. This book was released on 2013-10-10 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promotes a green approach to chemistry and chemical engineering for a sustainable planet With this text as their guide, students will gain a new outlook on chemistry and engineering. The text fully covers introductory concepts in general, organic, inorganic, and analytical chemistry as well as biochemistry. At the same time, it integrates such concepts as greenhouse gas potential, alternative and renewable energy, solvent selection and recovery, and ecotoxicity. As a result, students learn how to design chemical products and processes that are sustainable and environmentally friendly. Green Chemistry and Engineering presents the green approach as an essential tool for tackling problems in chemistry. A novel feature of the text is its integration of introductory engineering concepts, making it easier for students to move from fundamental science to applications. Throughout this text, the authors integrate several features to help students understand and apply basic concepts in general chemistry as well as green chemistry, including: Comparisons of the environmental impact of traditional chemistry approaches with green chemistry approaches Analyses of chemical processes in the context of life-cycle principles, demonstrating how chemistry fits within the complex supply chain Applications of green chemistry that are relevant to students' lives and professional aspirations Examples of successful green chemistry endeavors, including Presidential Green Chemistry Challenge winners Case studies that encourage students to use their critical thinking skills to devise green chemistry solutions Upon completing this text, students will come to understand that chemistry is not antithetical to sustainability, but rather, with the application of green principles, chemistry is the means to a sustainable planet.
Download or read book Guidelines for Setting Specific Concentration Limits for Carcinogens in Annex I of Directive 67 548 EEC written by and published by . This book was released on 1999 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guidelines for Integrating Process Safety into Engineering Projects written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2018-11-05 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is much industry guidance on implementing engineering projects and a similar amount of guidance on Process Safety Management (PSM). However, there is a gap in transferring the key deliverables from the engineering group to the operations group, where PSM is implemented. This book provides the engineering and process safety deliverables for each project phase along with the impacts to the project budget, timeline and the safety and operability of the delivered equipment.
Download or read book Risk based Systems Analysis for Emerging Technologies written by and published by . This book was released on 1995 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: The risk-based systems analysis model was designed to establish funding priorities among competing technologies for tank waste remediation. The model addresses a gap in the Department of Energy's (DOE's) ''toolkit'' for establishing funding priorities among emerging technologies by providing disciplined risk and cost assessments of candidate technologies within the context of a complete remediation system. The model is comprised of a risk and cost assessment and a decision interface. The former assesses the potential reductions in risk and cost offered by new technology relative to the baseline risk and cost of an entire system. The latter places this critical information in context of other values articulated by decision makers and stakeholders in the DOE system. The risk assessment portion of the model is demonstrated for two candidate technologies for tank waste retrieval (arm-based mechanical retrieval -- the ''long reach arm'') and subsurface barriers (close-coupled chemical barriers). Relative changes from the base case in cost and risk are presented for these two technologies to illustrate how the model works. The model and associated software build on previous work performed for DOE's Office of Technology Development and the former Underground Storage Tank Integrated Demonstration, and complement a decision making tool presented at Waste Management 1994 for integrating technical judgements and non-technical (stakeholder) values when making technology funding decisions.
Download or read book Guidelines for Process Safety Acquisition Evaluation and Post Merger Integration written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2013-11-13 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is crucial for process safety professionals to be aware of best practices for post merger integration at any level. A compilation of industry best practices from both technical and financial perspectives, this book provides a single reference that addresses acquisitions and merger integration issues related to process safety. Presently, there are limited references on how to handle acquisitions in several different CCPS publications and almost no coverage of the post-merger integration issue, so this reference fills a notable gap in the coverage.
