Download or read book Integrated Study of Protein Kinases written by Michelle McGuire and published by . This book was released on 2015-03-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth knowledge of protein kinases. The aim of this book is to educate readers regarding protein kinases. As regulators of protein function, protein kinases are concerned with the control of cellular functions through complicated signaling pathways, enabling fine tuning of physiological functions. This book is an integrated effort, with contributions from experts in modern science from across the globe. Existing literature is reviewed in this book, and occasionally, new data on the function of protein kinases in different systems is also provided. The implications of these findings in the light of activated protein kinases in genes and biological role, and the role of kinases and phosphatases in host-pathogen interactions are discussed.
Download or read book Next Generation Kinase Inhibitors written by Paul Shapiro and published by Springer Nature. This book was released on 2020-07-14 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.
Download or read book Targeting Protein Kinases for Cancer Therapy written by David J. Matthews and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Download or read book Protein Kinase Inhibitors written by Md. Imtaiyaz Hassan and published by Academic Press. This book was released on 2022-05-19 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development. Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation Examines protein kinase inhibitor drugs in various stages of clinical trials and development Offers methods and protocols for protein kinase inhibitor research studies and drug design and development Includes chapter contributions from international leaders in the field
Download or read book Protein Kinases in Drug Discovery written by Rossen Donev and published by Academic Press. This book was released on 2021-02-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. Contains timely chapters written by well-renown authorities in their field Includes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students Integrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients
Download or read book Protein Kinases written by James Robert Woodgett and published by Oxford University Press, USA. This book was released on 1994 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Molecular Biology is a series of books designed to report on rapidly evolving, key areas of molecular biology research. Individual chapters are written by leading researchers who are specialists in their fields. Each book is carefully organized to provide an integrated analysis of current progress in the area covered. Protein kinases share a unique catalytic function and are involved in virtually all regulated processes, from ion transport and metabolic pathways to DNA replication and differentiation. They act as powerful transducers of information, amplifying weak signals or integrating complex messages. Above all, they are the primary mechanism for acute coordination of the myriad of processes that continuously flux during the life cycle of the cell. The daunting progress made in the last decade in this area has been encapsulated in this book, written by established experts in the field. Protein Kinases presents detailed, up-to-date discussions of structural, functional, and genetic aspects of protein phosphorylation research. It is essential reading for all those interested in signal transduction and the control of cellular processes by protein phosphorylation.
Download or read book Protein Kinases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Kinases Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Kinases as Drug Targets written by Bert Klebl and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.
Download or read book Inhibitors of Protein Kinases and Protein Phosphates written by Lorenzo A. Pinna and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.
Download or read book Protein Kinases in Development and Disease written by and published by Academic Press. This book was released on 2017-02-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms Includes a broad scope of topics that are addressed Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge
Download or read book Protein Kinase Functions written by James Robert Woodgett and published by Oxford University Press, USA. This book was released on 2000 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just anupdate of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updatedand new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFss superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individualkinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to theirenvironments.
Download or read book Protein Kinases Comprehensive Researches written by Michelle McGuire and published by . This book was released on 2015-01-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book of advanced researches aims to serve as a resource guide in the field of protein kinases. The aim of this book is to educate readers on protein kinases. As regulators of protein function, protein kinases are concerned with the control of cellular functions through complicated signaling pathways, enabling fine tuning of physiological functions. This book is an integrated effort, with contributions from experts in modern science from across the globe. Existing literature is reviewed in this book, and occasionally, new data on the function of protein kinases in different systems is also provided. The book discusses broad topics related to the role of c-Src tyrosine kinase in bone metabolism, protein kinases and pancreatic islet function, kinases in spinal plasticity etc.
Download or read book Protein Kinase C written by Peter J. Parker and published by . This book was released on 1997-01-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book information from the wide range of disciplines involved in the investigation of protein kinase C is juxtaposed to provide an integrated picture of current research activities. The contributors are active researchers with specific expertise in a particular area. The basic biochemistry of protein kinase C, its appearance as a heterogeneous gene family, its structure, activation and regulation as well as the biology of this enzyme, its relevance to processes like cellular differentiation or synaptic transmission, are described in considerable detail. Explaining the heterogeneity in functional terms is in fact one of the main challenges facing researchers.
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Download or read book Protein Kinase Technologies written by Hideyuki Mukai and published by Humana Press. This book was released on 2017-05-04 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into two convenient sections, Protein Kinase Technologies collects contributions from experts in the field examining recent methodologies and techniques generally applicable to protein kinase research as well as to individual protein kinases which require special attention in neuroscience. These chapters will not only be practical instructions useful for readers' daily work in setting up and performing research but also thought-provoking and enjoyable reviews of recent advancements of individual protein kinases in neuroscience. Written for the highly successful Neuromethods series, this work contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and accessible, Protein Kinase Technologies seeks to foster cross-talk among investigators who study different protein kinases, and will also be beneficial for the entry of new investigators into this pivotal field.
Download or read book Protein Kinases and Stress Signaling in Plants written by Girdhar K. Pandey and published by John Wiley & Sons. This book was released on 2020-12-03 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of stress signaling in plants using genomics and functional genomic approaches Improving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation. Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals. This timely resource: Summarizes the role of various kinases involved in stress management Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions Examines mitogen-activated protein kinases (MAPKs) in different stresses Describes the different aspects of calcium signaling under different stress conditions Examines photo-activated kinases (PAPKs) in varying light conditions Briefs the presence of tyrosine kinases in plants Highlights the cellular functions of receptor ]like protein kinases (RLKs) Possible implication of these kinases in developing stress tolerant crops Protein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.
