Download or read book Integrated Genomics written by Guy A. Caldwell and published by John Wiley & Sons. This book was released on 2006-08-04 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Genomics: A Discovery-Based Laboratory Course introduces the excitement of discovery to the basic molecular biology laboratory. Utilizing up-to-date molecular biology protocols and a basic experimental design, this text offers experience with three different model systems. Students will become familiar with the simplicity and power of single-celled organisms, Escherichia coli and Saccharomyces cerevisiae, as they search for genes that interact and function within the nematode Caenorhabditis elegans. Incorporated throughout the course are exercises designed to offer students familiarity with the wealth of bioinformatics data that can be accessed on the World Wide Web. Following completion of interaction studies within the yeast, the course is designed to allow students to examine the functional consequences of reducing a gene’s function within the multicellular worm that is both simple and inexpensive to maintain within a laboratory. The inclusion of alternative experiments allow for flexibility in determining the ending date or goal of the laboratory, as well as working within the available budget and resources of most any classroom environment. Further striking features of this title are: An accompanying Web site providing PowerPoint slides, plus links to the internet, and regular updates as bioinformatics databases evolve and methods improve. www.wiley.com/go/caldwell Inclusion of modern genomic/proteomic technologies such as the yeast two-hybrid system and RNAi Detailed experimental protocols and easy access to instructional materials This discovery-based laboratory course provides excellent practical training for those pursuing career paths in biomedicine, pharmacy, and biotechnology.
Download or read book Medical Genetics written by G. Bradley Schaefer and published by McGraw Hill Professional. This book was released on 2013-11-22 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introductory text on how to integrate basic genetic principles into the practice of clinical medicine Medical Genetics is the first text to focus on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. It is intended to be a text that you can use throughout medical school and refer back to when questions arise during residency and, eventually, practice. Medical Genetics is written as a narrative where each chapter builds upon the foundation laid by previous ones. Chapters can also be used as stand-alone learning aids for specific topics. Taken as a whole, this timely book delivers a complete overview of genetics in medicine. You will find in-depth, expert coverage of such key topics as: The structure and function of genes Cytogenetics Mendelian inheritance Mutations Genetic testing and screening Genetic therapies Disorders of organelles Key genetic diseases, disorders, and syndromes Each chapter of Medical Genetics is logically organized into three sections: Background and Systems – Includes the basic genetic principles needed to understand the medical application Medical Genetics – Contains all the pertinent information necessary to build a strong knowledge base for being successful on every step of the USMLE Case Study Application – Incorporates case study examples to illustrate how basic principles apply to real-world patent care Today, with every component of health care delivery requiring a working knowledge of core genetic principles, Medical Genetics is a true must-read for every clinician.
Download or read book Integrating Large Scale Genomic Information into Clinical Practice written by Institute of Medicine and published by National Academies Press. This book was released on 2012-03-06 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: The initial sequencing of the human genome, carried out by an international group of experts, took 13 years and $2.7 billion to complete. In the decade since that achievement, sequencing technology has evolved at such a rapid pace that today a consumer can have his or her entire genome sequenced by a single company in a matter of days for less than $10,000, though the addition of interpretation may extend this timeframe. Given the rapid technological advances, the potential effect on the lives of patients, and the increasing use of genomic information in clinical care, it is important to address how genomics data can be integrated into the clinical setting. Genetic tests are already used to assess the risk of breast and ovarian cancers, to diagnose recessive diseases such as cystic fibrosis, to determine drug dosages based on individual patient metabolism, and to identify therapeutic options for treating lung and breast tumors, melanoma, and leukemia. With these issues in mind and considering the potential impact that genomics information can have on the prevention, diagnosis, and treatment of disease, the Roundtable on Translating Genomic-Based Research for Health hosted a workshop on July 19, 2011, to highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice. Integrating Large-Scale Genomic Information into Clinical Practice summarizes the speaker presentations and the discussions that followed them. This report focuses on several key topics, including the analysis, interpretation, and delivery of genomic information plus workforce, ethical, and legal issues.
Download or read book Biochemistry Cell and Molecular Biology and Genetics written by Zeynep Gromley and published by Thieme. This book was released on 2021-01-06 with total page 1091 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates biochemical, molecular, and cellular health and disease processes into one essential text! Biochemistry, Cell and Molecular Biology, and Genetics: An Integrated Textbook by Zeynep Gromley and Adam Gromley is the first to cover molecular biology, cell biology, biochemistry (metabolism), and genetics in one comprehensive yet concise resource. Throughout the book, these topics are linked to other basic medical sciences, such as pharmacology, physiology, pathology, immunology, microbiology, and histology, for a truly integrated approach. Key Highlights Easy-to-read text enhances understanding of underlying molecular mechanisms of disease Nearly 500 illustrations and tables help reinforce chapter learning objectives Textboxes throughout make connections with other preclinical disciplines End of unit high-order clinical vignette questions with succinct explanations help integrate basic science topics with clinical medicine This textbook provides a robust review for medical students preparing for courses as well as exams. Dental, pharmacy, physician's assistant, nursing, and graduate students in pre-professional/bridge programs will also find this a beneficial learning tool.
Download or read book Machine Learning and Network Driven Integrative Genomics written by Mehdi Pirooznia and published by Frontiers Media SA. This book was released on 2021-04-29 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Kiwifruit Genome written by Raffaele Testolin and published by Springer. This book was released on 2016-05-02 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basic botanical features of kiwifruit and its wild relatives, reports on the steps that led to its genome sequencing, and discusses the results obtained with the assembly and annotation. The core chapters provide essential insights into the main gene families that characterize this species as a crop, including the genes controlling sugar and starch metabolism, pigment biosynthesis and degradation, the ascorbic-acid pathway, fruit softening and postharvest metabolism, allergens, and resistance to pests and diseases. The book offers a valuable reference guide for taxonomists, geneticists and horticulturists. Further, since information gained from the genome sequence is extraordinarily useful in assessing the breeding value of individuals based on whole-genome scans, it will especially benefit plant breeders. Accordingly, chapters are included that focus on gene introgression from wild relatives and genome-based breeding.
Download or read book An Integrated Approach to Genomics written by Joel White and published by Callisto Reference. This book was released on 2021-11-16 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes are the functional units of heredity that direct the production of proteins. The field of genomics is concerned with the collective quantification and characterization of genes, as well as the analysis and sequencing of genomes using bioinformatics and high throughput DNA. It also studies intragenomic processes like heterosis, epistasis, pleiotropy, etc. Some of the research areas in genomics are the study of gene translation, transcription and protein-protein interactions, 3D structures of the protein encoded by a genome, epigenetic modifications on a cell's DNA, and bacterial and viral genomes. Advances in genomics have furthered the understanding of complex biological processes. It has also revolutionized the sectors of medicine and biotechnology. Genomics is an upcoming field of science that has undergone rapid development over the past few decades. It elucidates new techniques in a multidisciplinary manner. This book includes contributions of experts and scientists which will provide innovative insights into this field.
Download or read book Genomics in Aquaculture written by Simon A MacKenzie and published by Academic Press. This book was released on 2016-07-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics in Aquaculture is a concise, must-have reference that describes current advances within the field of genomics and their applications to aquaculture. Written in an accessible manner for anyone—non-specialists to experts alike—this book provides in-depth coverage of genomics spanning from genome sequencing, to transcriptomics and proteomics. It provides, for ease of learning, examples from key species most relevant to current intensive aquaculture practice. Its coverage of minority species that have a specific biological interest (e.g., Pleuronectiformes) makes this book useful for countries that are developing such species. It is a robust, practical resource that covers foundational, functional, and applied aspects of genomics in aquaculture, presenting the most current information in a field of research that is rapidly growing. - Provides the latest scientific methods and technologies to maximize efficiencies for healthy fish production, with summary tables for quick reference - Offers an extended glossary of technical and methodological terms to help readers better understand key biological concepts - Describes state-of-the-art technologies, such as transcriptomics and epigenomics, currently under development for future perspective of the field - Covers minority species that have a specific biological interest (e.g., Pleuronectiformes), making the book useful to countries developing such species
Download or read book Model Integrate Search Repeat written by Anna Bernasconi and published by Springer Nature. This book was released on 2024-01-11 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a revised version of the PhD dissertation written by the author to receive her PhD from the Department of Electronics, Information and Bioengineering at Politecnico di Milano, Italy. The work deals with one of the central objectives of the European Research Council project “Data-Driven Genomic Computing”, i.e., building an integrated repository for genomic data. It reflects the research adventure that starts from modeling biological data, goes through the challenges of integrating complex data and their describing metadata and finally builds tools for searching the data empowered by a semantic layer. The results of this thesis are part of a broad vision: the availability of conceptual models, related databases, and search systems for both humans and viruses genomics will provide important opportunities for research, especially if virus data will be connected to its host, the human being, who is the provider of genomic and phenotype information. In 2023, the PhD dissertation won the CAiSE PhD Award, granted to outstanding PhD theses in the field of information systems engineering.
Download or read book Collaborative Genomics Projects A Comprehensive Guide written by Margi Sheth and published by Academic Press. This book was released on 2016-02-24 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting. This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a NIH- funded effort to generate a comprehensive catalog of genomic alterations in more than 35 cancer types. As the cost of genomic sequencing is decreasing, more and more researchers are leveraging genomic data to inform the biology of disease. The amount of genomic data generated is growing exponentially, and protocols need to be established for the long-term storage, dissemination, and regulation of this data for research. The book's authors create a complete handbook on the management of research projects involving genomic data as learned through the evolution of the TCGA program, a project that was primarily carried out in the US, but whose impact and lessons learned can be applied to international audiences. Establishes a framework for managing large-scale genomic research projects involving multiple collaborators Describes lessons learned through TCGA to prepare for potential roadblocks Evaluates policy considerations that are needed to avoid pitfalls Recommends strategies to make project management more efficient
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Download or read book Mechanisms of Adaptation written by J.R. Spkatch and published by Elsevier. This book was released on 2014-04-24 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bacteria: Volume VII: Mechanisms of Adaptation explores the mechanisms of bacterial adaptations and covers topics ranging from bacterial spores, cysts, and stalks to nitrogen fixation, bacterial chemotaxis, bacteriophage growth, and the structure and biosynthesis of bacterial cell walls. The roles of appendages and surface layers in adaptation of bacteria to their environment are also considered, along with cell division in Escherichia coli. This volume is comprised of nine chapters and begins with a discussion on the structure, properties, formation, and regulation of spores, cysts, and stalks in actinomycetes, blue-green bacteria, myxobacteria, Bacillus, Azotobacter, and Caulobacter. The reader is then introduced to the biochemistry, regulation, genetics, and evolution of nitrogen fixing in organisms; the receptors involved in bacterial chemotaxis and the nature of the sensing mechanism; the outer membrane of gram-negative bacteria; and bacterial functions involved in nutrient detection and acquisition. The roles played by organelles and surface layers in the adaptation of bacteria to their environment are also examined. The final chapter deals with the regulation of, and coordination between, the multitude of events involved in cell division in Escherichia coli. This monograph will be a useful resource for microbiologists, bacteriologists, biochemists, and biologists.
Download or read book Genomes Browsers and Databases written by Peter Schattner and published by Cambridge University Press. This book was released on 2008-06-16 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent explosive growth of biological data has lead to a rapid increase in the number of molecular biology databases. Held in many different locations and often using varying interfaces and non-standard data formats, integrating and comparing data from these multiple databases can be difficult and time-consuming. This book provides an overview of the key tools currently available for large-scale comparisons of gene sequences and annotations, focusing on the databases and tools from the University of California, Santa Cruz (UCSC), Ensembl, and the National Centre for Biotechnology Information (NCBI). Written specifically for biology and bioinformatics students and researchers, it aims to give an appreciation of the methods by which the browsers and their databases are constructed, enabling readers to determine which tool is the most appropriate for their requirements. Each chapter contains a summary and exercises to aid understanding and promote effective use of these important tools.
Download or read book Multi omic Data Integration written by Paolo Tieri and published by Frontiers Media SA. This book was released on 2015-09-17 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From these considerations, a novel, pressing request arises from the life sciences to design methodologies and approaches that allow for these data to be interpreted as a whole, i.e. as intertwined molecular signatures containing genes, proteins, mRNAs and miRNAs, able to capture inter-layers connections and complexity. Papers discuss data integration approaches and methods of several types and extents, their application in understanding the pathogenesis of specific diseases or in identifying candidate biomarkers to exploit the full benefit of multi-omic datasets and their intrinsic information content. Topics of interest include, but are not limited to: • Methods for the integration of layered data, including, but not limited to, genomics, transcriptomics, glycomics, proteomics, metabolomics; • Application of multi-omic data integration approaches for diagnostic biomarker discovery in any field of the life sciences; • Innovative approaches for the analysis and the visualization of multi-omic datasets; • Methods and applications for systematic measurements from single/undivided samples (comprising genomic, transcriptomic, proteomic, metabolomic measurements, among others); • Multi-scale approaches for integrated dynamic modelling and simulation; • Implementation of applications, computational resources and repositories devoted to data integration including, but not limited to, data warehousing, database federation, semantic integration, service-oriented and/or wiki integration; • Issues related to the definition and implementation of standards, shared identities and semantics, with particular focus on the integration problem. Research papers, reviews and short communications on all topics related to the above issues were welcomed.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Genomics in Biosecurity written by Manousos E. Kambouris and published by Academic Press. This book was released on 2021-11-24 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics in Biosecurity: Principles and Applications of Genomic Technologies in Expanded Biosecurity Concepts, in the Translational and Applied Genomics series, explains in definite and practical terms the applicability of genomic technologies in every aspect of biosecurity, from emergent diagnostics to bioterrorism, agroterrorism, next generation biowarfare, biosurveillance and risk assessment. This book offers an integrated discussion of genomics and GCBR (global catastrophic biological risks) events, considering both basic aspects of biosecurity genomics and application of genomic technologies to drive new solutions. Readers will find evidence-based strategies to apply genomics in disease and pathogen monitoring and diagnosis, and more. Social aspects of GCBR events and genomic biosecurity, such as issues of terrorism, policy ethics, and practice, are also considered in-depth. - Examines the use of genomics in pathogen monitoring and diagnosis, biosurveillance, and countermeasures for spontaneous and perpetrated events - Discusses social, ethical, and policy aspects of GCBR events and the use of genomic technologies in biosecurity - Empowers new solutions in biorestoration, biocrime, counterbioterrorism, disaster management, and humanitarian crisis response - Features chapter contributions from a range of international specialists
Download or read book Integrative Physiology in the Proteomics and Post Genomics Age written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.
