Download or read book Innate Lymphoid Cells in Cancer Friends or Foes written by Nicolas Jacquelot and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Natural Killer Cells in Human Diseases Friends or Foes written by Vincent Vieillard and published by Frontiers Media SA. This book was released on 2018-02-23 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: NK cells are lymphocytes of the innate immune system that share some features with adaptive immune cells like T cells. They are well known for their importance to control viral infections and tumor development, but also intracellular bacterial and parasitic infections. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating receptors controls the function of NK cells. Activated NK cells respond by killing the infected or tumor cells without prior sensitization, and by producing cytokines and chemokines. It has been shown that NK cells cross-talk with other immune cells, such as dendritic cells and macrophages, can shape T cell and B cell immune responses through direct interactions as well as by virtue of their cytokine/chemokine production. NK cells can also regulate immune responses by killing other immune cells, including activated T cells, or by producing anti-inflammatory cytokines upon excessive inflammation. However, NK cells are not friends in all situations. Indeed, it has been shown in LCMV-infected murine models that, depending on the viral inoculation load, NK cells may either help fight infection or can promote chronic infection. Moreover in cancer models, it has been shown that NK cells can kill anti-tumoral T cells. Recent studies of NK cells in patients with cancer support the notion of detrimental roles of NK cells. Furthermore, studies implicate NK cells in contributing to both graft rejection and tolerance to an allograft. In some autoimmune diseases, like rheumatoid arthritis, NK cells may promote disease pathogenesis. The scope of this Research Topic is to present and discuss knowledge on the role of NK cells in various diseases settings: viral infections as well as other infections, cancer, transplantation, and autoimmunity. The aim is to discuss how NK cells respond during disease and specifically when, why and how NK cells can be harmful and if they exert different functions (production of specific cytokines, inhibition of other immune cells through other mechanisms beside cytotoxicity) in these situations. Which are the NK cell subsets that play beneficial or deleterious roles in these diseases? Are there different phenotypes associated with protective NK cells (e.g. antiviral, antitumoral) and NK cells involved in disease pathogenesis? How are these diverse NK cells activated and do they function primarily through direct cytotoxicity, ADCC or cytokine and chemokine production? What are the signals or interactions that can change and shape the NK cell response shifting them from protective to harmful? We thank the authors that submitted reviews and original research manuscripts that help to better understand these questions, with the aim that this will help the scientific community to determine what could be the main future research directions to better understand the role of NK cells in disease protection or development.

Download or read book Anesthesia and cancer Friend or foe written by Lucillia Bezu and published by Frontiers Media SA. This book was released on 2023-01-27 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer written by Loredana Cifaldi and published by Frontiers Media SA. This book was released on 2020-07-31 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

Download or read book In Memoriam of Professor Alessandro Moretta written by Eric Vivier and published by Frontiers Media SA. This book was released on 2020-05-21 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Natural Killer Cells in Tissue Compartments written by Massimo Vitale and published by Frontiers Media SA. This book was released on 2020-03-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book New insights into innate immune cell based immunotherapies in cancer written by Mary Poupot-Marsan and published by Frontiers Media SA. This book was released on 2024-04-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunotherapeutics written by Rossen Donev and published by Academic Press. This book was released on 2022-03-17 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapeutics, Volume 129 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Vaccines for the prophylaxis and treatment of HPV, Lung-targeted RNA-based therapeutics, Clostridium difficile: Current overview and future perspectives, Antivenoms for treatment of snake bites, Natural killer cell-based strategies for immunotherapy of cancer, Immunological insights of selectins in human disease mechanism, Current update, challenges, and future aspects of immunotherapeutics in non-small cell lung cancer, In silico interaction analysis of NEMO binding domain peptide on the NFkB protein, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated release includes the latest information on Immunotherapeutics

Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

Download or read book Alpha fetoprotein and Its Receptor in Fixing the Cancer Brakes written by Vladimir N. Pak and published by Cambridge Scholars Publishing. This book was released on 2021-03-25 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the crucial role of a unique alpha-fetoprotein (AFP) in the treatment of cancer. AFP can deliver toxins through specific receptors re-expressed in the majority of cancer cells, serving as a targeted chemotherapy. More importantly, AFP+toxin harnesses the patient’s immune system in order to attack cancer. Depleting the regulatory top monocyte-derived suppressor cells (MDSCs) activates both the innate and adaptive immune responses. The thoroughly chosen toxins switch on apoptosis in MDSCs, restore the broken one in cancer cells, and destroy them naturally without any harmful by-products. Injections with AFP+toxin preparations have shown promising results in animals and the treatment of cancer patients. In addition to this breakthrough, the book also discusses the peroral administration of porcine AFP non-covalent complexes with selected toxins in patients with metastases. It will appeal to science researchers, clinicians, and medical students, as well as the more general reader.

Download or read book Innate Lymphoid Cell Development Migration and Function written by Paula Licona-Limón and published by Frontiers Media SA. This book was released on 2023-10-23 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell lineages derived from common lymphoid progenitors (CLPs) play a critical role in antigen recognition, acute and long term protection against pathogens, and maintenance of immune homeostasis. CLPs give rise to adaptive immune cells that bear unique antigen receptors and to innate immune cells that perform non-redundant roles, particularly during early effector responses, by facilitating local immunity and shaping the ensuing adaptive response. Recent discoveries indicate that innate lymphoid cells (ILCs) exert essential modulatory effects in normal and pathological responses. Because adaptive and innate lymphoid cells share transcription factors, cytokines, and molecular surface markers, it is essential to dissect the contribution of innate lymphoid cell subsets to immune tolerance, maintenance of tissue homeostasis and during the development of inflammatory responses. In this research topic we will focus on the functional diversity and individual roles that the variety of innate lymphoid cell subsets perform in steady state as well as in different pathological conditions including infection and autoimmunity. This will contribute to the generation of a more comprehensive and integrated view of how these cells interact with the environment, collaborate with other cells and regulate tissue homeostasis and immunity in a context-dependent manner. We welcome Original Research, Review, and Mini-review articles related to, but not limited to the following topics: 1. Innate lymphoid cell development and migration 2. Characterization and identification of signals controlling innate lymphoid differentiation and function 3. Molecular interactions between innate lymphoid cells and other immune and non-immune subsets 4. Role of ILCs in tissue homeostasis 5. Role of ILCs in pathology We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Download or read book Differentiation and Mechanisms of Activation of Innate Lymphoid Cells written by Marina Cella and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy written by Salem Chouaib and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The role of immunophenotype in tumor immunotherapy response written by Fu Wang and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tumor Microenvironment Signaling Networks in Pathophysiology and Therapeutics written by Francesca Pirini and published by Frontiers Media SA. This book was released on 2022-10-19 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book CD4 T cells in HIV A friend or foe written by Sunil Kannanganat Sidharthan and published by Frontiers Media SA. This book was released on 2023-07-26 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dysfunction of the Immune System During Acute Kidney Injury written by Giuseppe Castellano and published by Frontiers Media SA. This book was released on 2022-07-14 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: