Download or read book Innate Immunity Programming and Memory in Resolving and Non Resolving Inflammation written by Liwu Li and published by Frontiers Media SA. This book was released on 2020-03-18 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Soluble Immune Mediators by Non Coding RNAs written by Flavia Bazzoni and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book S adenosylmethionine dependent Methyltransferases Structures And Functions written by Robert M Blumenthal and published by World Scientific. This book was released on 1999-07-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.
Download or read book MicroRNAs and Other Non Coding RNAs in Inflammation written by Catherine M. Greene and published by Springer. This book was released on 2015-03-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn’s disease, diabetes) and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
Download or read book Oral Mucosal Immunity and Microbiome written by Georgios N. Belibasakis and published by Springer Nature. This book was released on 2019-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first International Conference on Oral Mucosal Immunity and Microbiome (OMIM) aimed to highlight cutting-edge basic and translational research from an oral immunological and microbiological perspective. Oral diseases with a microbial etiology are the most prevalent chronic diseases of humans. Whilst not life-threatening, they can significantly compromise quality of life, are associated with increased risk for certain systemic diseases, and pose heavy financial burdens to national health systems. Hence, periodontal and peri-implant diseases, dental caries, root canal infections and mucosal infections are significant global public health problems. In this book global experts summarize and discuss the latest progress made in oral mucosal immunity and the oral microbiome. Target audience is basic and/or translational researchers with expertise in host immunity and microbiome research, and interest in oral health and disease. This volume provides a much needed quantum leap in the field, by joining forces to address gaps at the oral mucosal immunity-microbiome cross-talk.
Download or read book The Role of Toll Like Receptor 4 in Infectious and Non Infectious Inflammation written by Carlo Rossetti and published by Springer Nature. This book was released on 2020-10-30 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.
Download or read book Toll like Receptors in Health and Disease written by Vijay Kumar and published by Springer Nature. This book was released on 2022-06-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
Download or read book Arrest chemokines written by Klaus Ley and published by Frontiers Media SA. This book was released on 2015-05-20 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.
Download or read book Innate Immunity in Health and Disease written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2021-08-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.
Download or read book Encyclopedia of Endocrine Diseases written by and published by Academic Press. This book was released on 2018-09-12 with total page 4225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Endocrine Diseases, Second Edition, Five Volume Set comprehensively reviews the extensive spectrum of diseases and disorders that can occur within the endocrine system. It serves as a useful and comprehensive source of information spanning the many and varied aspects of the endocrine end metabolic system. Students will find a concise description of the physiology and pathophysiology of endocrine and metabolic functions, as well as their diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters explore the latest advances and hot topics that have emerged in recent years, such as the molecular basis of endocrine and metabolic diseases (mutations, epigenetics, signaling), the pathogenesis and therapy of common endocrine diseases (e.g. diabetes and endocrine malignancies), new technologies in endocrine research, new methods of treatment, and endocrine toxicology/disruptors. Covers all aspects of endocrinology and metabolism Incorporates perspectives from experts working within the domains of biomedicine (e.g. physiology, pharmacology and toxicology, immunology, genetics) and clinical sciences to provide readers with reputable, multi-disciplinary content from domain experts Provides a ‘one-stop’ resource for access to information as written by world-leading scholars in the field, with easy cross-referencing of related articles to promote understanding and further research
Download or read book Oral Microbiology and Immunology written by Richard J. Lamont and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries. Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are: links between oral infections and systemic disease revised and updated overview of the role of the immune system in oral infections thorough discussions of biofilm development and control more extensive illustrations and Key Points for student understanding Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries. Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are: links between oral infections and systemic disease revised and updated overview of the role of the immune system in oral infections thorough discussions of biofilm development and control more extensive illustrations and Key Points for student understanding Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice.
Download or read book Macrophage Plasticity in Sterile and Pathogen Induced Inflammation written by Ioannis Kourtzelis and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
Download or read book Critical Care Nephrology written by Claudio Ronco and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 1851 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This 2nd edition of Critical care nephrology continues to provide comprehensive coverage of the latest advances in critical care procedures for the adult or pediatric patient with renal diseases or disorders. It presents a common language and standardized guidelines to help multi-disciplinary physicians caring for the critically ill communicate more effectively. "--BOOK JACKET.
Download or read book Liver Fibrosis and MAFLD From Molecular Aspects to Novel Pharmacological Strategies written by Juan Armendariz-Borunda and published by Frontiers Media SA. This book was released on 2022-05-24 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Trained Immunity based Vaccines written by Jose Luis Subiza and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Download or read book Interaction of Nanomaterials With the Immune System Role in Nanosafety and Nanomedicine written by Paola Italiani and published by Frontiers Media SA. This book was released on 2018-04-10 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals recognisable by the immune system are engineered nanomaterials/ nanoparticles, new agents in our environment that are becoming common due to their presence in many products, from constructions and building material (e.g., solar cells, pigments and paints, tilesand masonry materials) to daily products (e.g., food packaging, cosmetics, and cigarettes). Human beings can be accidentally exposed to engineered nanomaterials when these are released from products containing them or during production in workplaces. Furthermore, intentional exposure occurs in medicine, as engineered nanoparticles are used as tools for improving delivery of drugs and vaccines, vaccine adjuvants and contrast agents in therapeutic, preventive and diagnostic strategies. Nanoparticles that come in contact with the immune system after unintentional exposure need to be eliminated from the organism as they represent a potential threat. In this case, however, due to their peculiar characteristics of size, shape, surface charge and persistence, nanoparticles may elicit undesirable reactions and have detrimental effects on the immune system, such as cytotoxicity, inflammation, anaphylaxis, immunosuppression. Conversely, nanomedicines need to escape immune recognition/elimination and must persist in the organism long enough for reaching their target and exerting their beneficial effects. Immune cells and molecules at the body surface (airway and digestive mucosae, skin) are the first that come in contact with nanomaterials upon accidental exposure, while immune effectors in blood are those that more easily come in contact with nanomedical products. Thus, evaluating the interaction of the immune system with nanoparticles/nanomaterials is a topic of key importance both in nanotoxicology and in nanomedicine. Immuno-nanosafety studies consider both accidental exposure to nanoparticles, which may occur by skin contact, ingestion or inhalation (at doses and with a frequency that are not known), and medical exposure, which takes place with a defined administration schedule (route, dose, frequency). Many studies focus on the interaction between the immune system and nanoparticles that, for medical purposes, have been specifically modified to stimulate immunity or to avoid immune recognition, as in the case of vaccine carriers/adjuvants or drug delivery systems, respectively. The aims of this Research Topic is to provide an overview of recent strategies: 1.for assessing the immunosafety of engineered nanomaterials/nanoparticles, in particular in terms of activation of inflammatory responses, such as complement activation and allergic reactions, based on the nanomaterial intrinsic characteristics and on the possible carry-over of bioactive contaminants such as LPS. Production of new nanoparticles taking into account their effects on immune responses, in order to avoid undesirable effects on one hand, and to design particles with desirable effects for medical applications on the other hand; 2.for designing more effective nanomedicines by either avoiding or exploiting their interaction with the immune systems, with particular focus on cancer diagnosis and therapy, and vaccination. This collection of articles gives a comprehensive view of the state-of-the-art of the interaction of nanoparticles with the immune system from the two perspectives of safety and medical use, and aims at providing immunologists with the relevant knowledge for designing improved strategies for immunologically safe nanomaterial applications.
