Download or read book Inhalation Toxicology written by Ulrich Mohr and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Part I. Approaches to Assessing the Toxicity of Airborne Toxicants Chapter 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science? . . . . . . . . . . . . . . . . . . . . . . . 1 D. v. Bates Chapter 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 J. D. Brain Chapter 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology . . . . . . . . . . . . . . . . . . . . . . . . 25 e. G. Plopper, A. Mir, J. St. George, N. Tyler, A. Mariassy, D. Wilson, S. Nishio, D. Cranz, J. Heidsiek, and D. Hyde Chapter 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials . . . . . . . . . . . . . . . . . 41 A. R. Dahl Part II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals Chapter 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments. . . . . . . . . .
Download or read book Inhalation Toxicology the Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment written by U MOHR (Ed) and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: APPROACHES TO ASSESSING THE TOXICITY OF AIRBORNE TOXICANTS; STANDARD-SETTING AS AN INTEGRATIVE EXERCISE: ALCHEMY, JUGGLING, OR SCIENCE; SPECIES DIFFERENCES IN INHALATION TOXICOLOGY: VARIATIONS IN EXPOSURE-DOSE RELATIONSHIPS AND MACROPHAGE FUNCTION; CELL POPULATIONS OF THE RESPIRATORY SYSTEM: INTERSPECIES DIVERSITY IN COMPOSITION, DISTRIBUTION AND MORPHOLOGY; COMPARATIVE METABOLIC BASIS FOR THE DISPOSITION AND TOXIC EFFECTS OF INHALED MATERIALS; METHODOLOGICAL ISSUES IN DESIGNING AND CONDUCTING STUDIES WITH LABORATORY ANIMALS; EXPOSURE FACILITIES AND AEROSOL GENERATION AND CHARACTERIZATION FOR INHALATION EXPERIMENTS; DIFFERENT METHODS USED IN ACUTE AND SUBCHRONIC INHALATION STUDIES OF POTENTIAL LUNG IRRITANTS, WITH PARTICULAR ATTENTION TO LUNG FUNCTION; CHRONIC INHALATION TOXICITY STUDIES: PROTOCOLS AND PITFALLS; CARCINOGENICITY PROTOCOLS.
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 1996-11-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research. The book covers techniques needed to: provide suitable clean air for experiments correctly generate the particles and gases being studied select the proper exposure system monitor the exposure prepare tissues for study ensure that animals do not have confounding lung disease The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.
Download or read book Assessment of Inhalation Hazards written by David V. Bates and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . xiii . . . . . . . . . . . . . Part I. Integrative Approach to Assessing Human Health Risk: Two Contemporary Problems Chapter 1. Integrating Diverse Data Sets to Assess the Risks of Airborne Pollutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 R.o. McClellan, R.G. Cuddihy, w.e. Griffith, and J. L. Mauderly Chapter 2. Risk Assessment for Radon Inhalation Based on Animal Exposure Data and Human Epidemiology . . . . . . . 23 . F. Steinhausler Part II. Types of Evidence: General Strengths and Weaknesses Section 1. Epidemiological Chapter 3. Inhalation Hazards: The Interpretation of Epidemiologic Evidence. . . . . . . . . . . . . . . . . . . . 39 . . . . . . . J.e. Bailar Chapter 4. Problems in Interpreting Epidemiological Data 49 P.N. Lee Section 2. Animal Chapter 5. Rodent Carcinogenicity Studies: Their Value and Limitations. . . . . . . . . . . . . . . . . . . . . . . . . . 61 . . . . . . . . . .
Download or read book Concepts In Inhalation Toxicology written by Roger O. McClellan and published by CRC Press. This book was released on 1995-09-25 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.
Download or read book Inhalation Toxicology written by Harry Salem and published by CRC Press. This book was released on 2005-12-22 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances
Download or read book Inhalation Toxicology Third Edition written by Harry Salem and published by CRC Press. This book was released on 2014-08-19 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book’s educational utility.
Download or read book Wildlife Toxicity Assessments for Chemicals of Military Concern written by Marc Williams and published by Elsevier. This book was released on 2015-05-21 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. - Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. - Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. - Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 2020-04-30 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.
Download or read book Annual Report of the Inhalation Toxicology Research Institute written by Inhalation Toxicology Research Institute and published by . This book was released on 1978 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants written by Rhoda G.M. Wang and published by CRC Press. This book was released on 2017-11-22 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.
Download or read book Problems of Inhalatory Toxicity Studies written by Peter Grosdanoff and published by . This book was released on 1984 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION INTO METHODOLOGICAL PROBLEMS IN INHALATION TOXICOLOGY; PROBLEMS AND CONCEPT OF SHORT TERM INHALATION TOXICITY STUDIES; ACUTE ORAL AND INHALATION TOXICITY; A CORRELATION OF EXPERIMENTAL RESULTS; HEAD ONLY AND NOSE ONLY EXPOSURE; WHOLE BODY EXPOSURE; VAPOR ATMOSPHERE GENERATION AND ANALYSIS; GENERATION OF AEROSOL FROM LIQUID AND SOLID TEST SUBSTANCE AND SAMPLING FOR AEROSOL ANALYSIS; GENERATION OF FIBROUS DUSTS AND SAMPLING FOR ANALYSIS; CRITERIA FOR THE SELECTION OF SUITABLE EXPERIMENTAL ANIMALS AND KEEPING METHODS FOR INHALATION EXPERIMENTS MAKING SPECIAL ALLOWANCE FOR LONG TIME EXPERIMENTS; THE SUITABILITY OF THE SYRIAN GOLDEN HAMSTER FOR CHRONIC INHALATION EXPERIMENTS; STUDIES OF PARTICLE DEPOSITION AND CLEARANCE IN HUMANS; DEPOSITION AND LUNG CLEARANCE OF INHALED PARTICLES IN EXPERIMENTAL ANIMALS; NON INHALATORY ADMINISTRATION INTO THE RESPIRATORY TRACT; ON THE PROBLEMS OF EXPERIMENTAL CARCINOGENICITY STUDIES WITH FIBROUS DUSTS ADMINISTERED INTRAPERITONEALLY, INTRATRACHEALLY, AND BY INHALATION; A REVIEW OF PULMONARY FUNCTION TESTS IN SMALL LABORATORY ANIMALS AND THEIR CORRELATION WITH HUMAN STUDIES; TESTING OF PULMONARY FUNCTION IN CONSCIOUS EXPERIMENTAL ANIMALS; LUNG FUNCTION TESTS ON HAMSTERS AND RATS USING THE WHOLE BODY PLETHYSMOGRAPH; COMPOSITION OF AIRWAY SECRETIONS IN EXPERIMENTAL BRONCHITIS ON THE RAT; ASSESSMENT OF EXTRAPULMONARY EFFECTS; PHYSIOLOGICAL CHANGES INDUCED BY INHALED SUBSTANCES WITH SPECIAL REFERENCE TO NEUROBEHAVIOURAL EFFECTS; BIOCHEMICAL ANALYSIS IN INHALATION TOXICITY STUDIES; ASSESSMENT OF INHALATION PHARMACOKINETICS IN CLOSED EXPOSURE SYSTEMS.
Download or read book Inhalation Toxicology Second Edition written by Harry Salem and published by CRC Press. This book was released on 2005-12-22 with total page 1056 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects. The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures. The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge.
Download or read book Drinking Water and Health written by National Research Council and published by National Academies Press. This book was released on 1986-02-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
Download or read book Inhalation Toxicology Studies of Aerosolized Products written by and published by . This book was released on 1980 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inhalation Toxicology written by Pranab Kumar Sen and published by . This book was released on 1994 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
