Download or read book Inhalation Studies Foundations Techniques written by R F. Phalen and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book INHALATION STUDIES FOUNDATIONS AND TECHNIQUES written by RF. PHALEN and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 1996-11-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research. The book covers techniques needed to: provide suitable clean air for experiments correctly generate the particles and gases being studied select the proper exposure system monitor the exposure prepare tissues for study ensure that animals do not have confounding lung disease The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.
Download or read book Inhalation Studies written by Robert F. Phalen and published by CRC Press. This book was released on 2008-10-22 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution. The Second Edition was motivated by: new developments in the ultrafine particle health effects and concentrated aerosol research advances in understanding postnatal lung growth and the deposition and clearance of inhaled particles new techniques in toxicity testing the explosion of knowledge in the genetic and molecular realms the introduction of a large number of transgenic animal models updated ethical guidelines for animal testing the emergence of aerosol medicine the growing threat of aerosol-related terrorism increased appreciation of nonpulmonary effects of inhaled substances use of medical scanning techniques to study respiratory tract structure the introduction of new inhalation exposure systems the emergence of aerosol concentrators for use in air pollution studies
Download or read book Inhalation Studies written by Robert F. Phalen and published by CRC PressI Llc. This book was released on 1984 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Aerosol and gases; 2. Basic morphology and physiology of the respiratory tract; 3. Establishing and controlling exposure environments; 4. Characterizing the exposure; 5. Methods for exposure animals.
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 2020-04-30 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.
Download or read book Advances in Controlled Clinical Inhalation Studies written by D.V. Bates and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Controlled Clinical Inhalation Studies represents scientific work presented at the 3rd International Inhalation Symposium held 1991 in Hannover, FRG. The symposium covered the new developments in this field of research. The main pollutants of interest were acid aerosols, fog, and indoor pollutants, while with regard to biological effects, an emphasis was placed on immunotoxicological and biochemical parameters. Tests on high risk groups were also considered. Initial chapters describe the outdoor environment as well as indoor air, measurement and quality - both at home and in the workplace. Besides methods for clinical inhalation and assessing personal exposure, new methodologies are particularly presented. Further chapters focus on the relevance of clinical data for regulatory decisions.
Download or read book Pharmaceutical Inhalation Aerosol Technology written by Anthony J. Hickey and published by CRC Press. This book was released on 1992 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.
Download or read book Procedures and Equipment Used in Inhalation Studies on Small Animals written by R. G. Thomas and published by . This book was released on 1963 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Procedures and equipment used in exposing small animals to aerosols of fission products are described. The exposure chamber with attached plethysmographs for monitoring the respiratory patterns is shown diagrammatically and the operational plan is set forth. Construction criteria for the plethysmographs are also included in detail. The descriptions concerning the animals include specifications on metabolism units and cleaning procedures, whole body counting and somewhat detailed sacrifice and necrotomy procedures.
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 2020-04-30 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.
Download or read book Generation Sampling and Analysis for Low Level GB Sarin Vapor for Inhalation Studies written by and published by . This book was released on 2003 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study tested and optimized various methodologies to generate, sample and characterize GB test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1- 44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations down to levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods for inhalation toxicology studies. The techniques employed for this study would lay the foundation for testing other chemical warfare agents, such as GF or VX.
Download or read book The Particulate Air Pollution Controversy written by Robert F. Phalen and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small invisible particles in the urban air, especially those produced by human activities, have recently stimulated intense scrutiny, debate, regulation, and legal proceedings. The stakes are high, both with respect to health impacts and economic costs, and the methods used previously to resolve similar issues are no longer adequate. Everyone on earth inhales thousands to millions of particles in each breath, so if urban particulate air pollution—particulate matter (PM)—is significantly hazardous, the negative impact on health could be staggering. Yet the activities that generate PM, such as farming, manufacturing, mining, transportation, and generating electricity, are themselves essential to human health and welfare. Scientists, regulators, legislators, activists, judges, lawyers, journalists, and representatives of the business community are actively involved in addressing the question of what should be done. This complex issue presents opportunities for critically assessing the relevant knowledge and for adopting more rigorous approaches to this and similar problems. What is the PM controversy, and why is it a good case study for how science and public policy might better interface? The PM controversy is the sum of the frequently heated debates related to the potential health risks from urban PM.
Download or read book Generation Sampling and Analysis for Low Level GF Cyclo Sarin Vapor for Inhalation Toxicology Studies written by and published by . This book was released on 2006 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation, sampling, and analysis system used for low-level GB inhalation studies was modified to test the nerve agent GF. A saturator cell used in conjunction with an inhalation chamber generated low level OF vapor at concentrations ranging from 0.004 - 0.05 mg/cu m. Additional testing with a syringe drive spray atomization system generated OF vapor concentrations from 0.7 - 2 mg/cu m. This capability was important to determine sub-lethal effects (primarily meioses) for inhalation toxicology studies. In addition, the techniques successfully employed for this study would lay the foundation for testing low-level VX.
Download or read book Generation Sampling and Analysis for Low Level GB SARIN Vapor for Inhalation Toxicology Studies written by and published by . This book was released on 2006 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study tested and optimized various methodologies to generate, sample, and characterize sarin (GB) test atmospheres in an inhalation chamber, particularly at low-vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1-44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations from 1 mg/m down to very low GB levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods. This capability was important to determine sub-lethal nerve agent effects for inhalation toxicology studies. In addition, the techniques employed for producing and maintaining low-level GB vapor would lay the foundation for testing other chemical warfare agents, such as GF or VX.
Download or read book Concepts In Inhalation Toxicology written by Roger O. McClellan and published by CRC Press. This book was released on 1995-09-25 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.
Download or read book Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents written by National Research Council and published by National Academies Press. This book was released on 2006-08-07 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies-including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)-be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.
Download or read book Handbook of Human Toxicology written by Edward J. Massaro and published by CRC Press. This book was released on 1997-07-09 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering some of the most important topics in modern toxicology, the Handbook of Human Toxicology is a unique and valuable addition to the current literature. It addresses issues, answers questions, and provides data related to. Within each of these five major sections are several carefully selected topics that reflect the current state of human to
