Download or read book Inflammatory Diseases and Copper written by John R. J. Sorenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic dis eases. The first report that copper complexes had antiinflammatory activity in an animal model of inflammation appeared twenty-two years after the dis covery of essentiality. In 1976, it was suggested that the active forms of the antiarthritic drugs are their copper complexes formed in vivo. This sugges tion has been confirmed and extended in the interim in over 200 recent publications. Individual biomedical scientists from many countries who have published in these areas recently saw a need for a meeting to exchange current re supporting new hypotheses. We search results and discuss the evidence met on the University of Arkansas Medical Sciences campus in Little Rock, Arkansas, August 10-13, 1981. Participants came from Australia, England, France, Germany, Israel, Italy, The Netherlands, Norway, Poland, Scotland, Sweden, Switzerland, Wales, Zimbabwe, and over twenty of the United States.
Download or read book Copper and Zinc in Inflammation written by Roberto Milanino and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of trace metals, especially copper and zinc, in the pathogenesis of rheumatic conditions has continued to receive much interest following the initial upsurge of research activity in the 1970s. Meantime also copper and zinc complexes receive continued attention for their potential anti-inflam matory actions. Since the previous major titles were published in this field some years ago (e. g. 1,2) it was considered timely to consider progress which has been made in the interceding period. Thus in this volume aspects are re viewed of the metabolism and biodisposition of copper and zinc, especially as they may be influenced by inflammatory processes, the mode of action of copper and zinc compounds in inflammatory states, and the actions of some newer copper complexes. While we still understand relatively little about how copper and zinc complexes work in inflammation, and indeed what the fate of the ligands and their complexed ions is in inflammation, it is hoped that this volume will be useful for giving a current view of the "state of art" in the field. Special thanks are given to the valued efforts of the contributors, Dr Peter Clarke (Publishing Director, Kluwer Academic Publishers) and Mrs Veronica Rainsford-Koechli for her help in proof-reading the manuscripts. K D Rainsford Hamilton, Ontario, Canada February 1989 References 1. Rainsford, K. D. , Brune, K. and Whitehouse, M. W. (eds) (1981). Elements in the pathogenesis a treatment of inflammation.
Download or read book Copper and Zinc in Inflammatory and Degenerative Diseases written by K. D. Rainsford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states. This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to treat a diversity of inflammatory and degenerative conditions.
Download or read book Copper and the Skin written by Jurij J. Hostynek and published by CRC Press. This book was released on 2006-08-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of conditions including skin irritation, sensitization, rheumatoid arthritis, and other inflammatory conditions. This source reviews general principles of percutaneous penetration to clarify the mechanisms contro
Download or read book Copper in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2000-04-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.
Download or read book Trace Elements and Minerals in Health and Longevity written by Marco Malavolta and published by Springer. This book was released on 2018-11-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.
Download or read book Dietary Reference Intakes for Vitamin A Vitamin K Arsenic Boron Chromium Copper Iodine Iron Manganese Molybdenum Nickel Silicon Vanadium and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.
Download or read book Studies in Bioinorganic Chemistry written by Stephen James Beveridge and published by . This book was released on 1980 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology of Copper Complexes written by John R. J. Sorenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in flammation appeared twenty-two years after the discovery of essen tiality. In 1976, it was suggested that the active forms of the anti arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis ease states. The presentations and interactive discussions that fol lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.
Download or read book Tietz Fundamentals of Clinical Chemistry Passcode Only written by Carl A. Burtis and published by W B Saunders Company. This book was released on 2007-11-06 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Pageburst digital textbook; the product description may vary from the print textbook. A condensed, student-friendly version of Tietz Textbook of Clinical Chemistry, this text uses a laboratory perspective to provide you with the chemistry fundamentals you need to work in a real-world, clinical lab. Accurate chemical structures are included to explain the key chemical features of relevant molecules. Offering complete, accurate coverage of key topics in the field, it's everything that you expect from the Tietz name! More than 500 illustrations and easy-to-read tables help you understand and remember key concepts. Key words, learning objectives, and other student-friendly features reinforce important material. Chapter review questions are included in an appendix to test your knowledge. A two-color design makes it easier to read and easy to find important topics. In-depth, reader-friendly content is appropriate for MT/CLS and MLT/CLT students and may also be used by laboratory practitioners, pathology residents, and others. A new chapter on newborn screening discusses the basic principles, screening recommendations, inborn errors, methods, and interpretation of results. A comprehensive glossary provides easy-to-find definitions of key terms. An Evolve website provides regular updates of content, answers to review questions, and web links to related sites for further research and study.
Download or read book Copper Bioavailability and Metabolism written by C Kies and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition is truly a science of the 20th century. That physiological disabilities could be caused by a lack of exogenous substances which could be supplied by foods is a concept of relatively recent origins. It is not surprising, therefore, that, until the last few years, much of nutritional science research was tied to: 1) establishing a cause and effect relationship between a physiological problem and its cure/prevention by a chemical substance in food; 2) quantifying the amount of the substance (nutrient) needed to prevent deficiency symptoms; and 3) quantifying the amounts of nutrients found in various food substances. That a nutrient might be present in apparently adequate amounts in foods consumed by an individual but could not be fully utilized because of the concurrent consumption of anti-nutrients has been recognized as being an important problem as, for example, iodine-deficiency goiters resulting from consumption of gOitrigens. That less specific, less dramatic interactions among nutrients and among nutrients and other food components might enhance or inhibit the absorption of nutrients from the intestines or of the metabolism of nutrients within the body is an area of current concern.
Download or read book Copper Deficiency and Toxicity written by Charles Archibald Owen and published by William Andrew. This book was released on 1981 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: A reference text for biochemical and clinical researchers reviews current knowledge of clinical and biochemical aspects of copper (Cu) deficiency and toxicity. Topics include: observations of acquired Cu deficiency in animal species; Cu deficiency arising from in vivo Cu complexing agents; inherited Cu deficiency (Menkes' desease and animal models thereof); acquired Cu toxicity in microorganisms, plants, and animals; human acquired Cu toxicity (intentional and unintentional Cu toxicity; medicalaspects of human Cu toxicity; toxicity treatment; non-Wilsonian liver disease); and beneficial applications ofCu toxicity and Cu therapy (e.g., antitumor therapy; treating infectious diseases; anti-inflammatory applications; Cu intrauterine devices; Cu supplementation. (wz).
Download or read book The Role of Copper and Its Chelation by Tetrathiomolybdate in Inflammation and Atherosclerosis written by Hao Wei and published by . This book was released on 2010 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these processes. The goals of my studies were to investigate the role of copper in systemic and vascular inflammation, endothelial activation, and atherosclerotic lesion development, using tetrathiomolybdate (TTM), a clinically-used copper chelator, as a specific means to manipulate cellular copper levels in vitro and in vivo. Incubation of human aortic endothelial cells (HAEC) with copper induced activation of the redox-sensitive transcription factors, nuclear factor kappa B (NF-kB) and activator protein-1 (AP-1) and up-regulation of mRNA and protein levels of adhesion molecules and the chemokine, monocyte chemotactic protein-1 (MCP-1), in a dose- and time-dependent manner. Furthermore, TTM inhibited TNF[alpha]-induced increases of mRNA and protein levels of adhesion molecules and MCP-1 in a dose-dependent manner. TNF[alpha]-induced activation of NF-kB and AP-1 also was dose-dependently attenuated by TTM, and inhibition of NF-kB activity was associated with decreased phosphorylation and degradation of its cytosolic inhibitory subunit, IkBa. In an in vivo model of systemic inflammation using of C57BL mice, oral TTM administration for three weeks significantly reduced bioavailable copper and inhibited lipopolysaccharide (LPS)-induced upregulation of inflammatory gene expression in aorta and heart. Tetrathiomolybdate also significantly inhibited LPS-induced increases of serum levels of soluble adhesion molecules, MCP-1, and pro-inflammatory cytokines. Similar inhibitory effects of TTM were observed on NF-kB and AP-1 activation in the heart and lungs. In apolipoprotein E-deficient (apoE-/-) mice, a well established animal model of human atherosclerosis, dietary supplementation with TTM for ten weeks significantly reduced bioavailable copper and attenuated atherosclerotic lesion development, which was particularly pronounced in the descending aorta. This anti-atherogenic outcome of TTM supplementation was accompanied by several anti-inflammatory effects, such as significantly declined serum levels of soluble adhesion molecules, reduced aortic gene expression of inflammatory mediators, and less aortic macrophage accumulation. Importantly, TTM supplementation for ten weeks did not cause liver toxicity or anemia. In conclusion, my studies provide the proof of concept that copper plays an important role in systemic and vascular inflammation and the pathogenesis of atherosclerosis, and demonstrate that tetrathiomolybdate exerts anti-inflammatory and anti-atherogenic effects in preclinical animal models. The possible implications of these findings for cardiovascular and inflammatory diseases in humans remain to be investigated.
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Download or read book Trace Elements in the Pathogenesis and Treatment on Inflammation written by Rainsford and published by Birkhäuser. This book was released on 1981 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Copper Transport and Its Disorders written by Arturo Leone and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of presentations at the first meeting devoted to the mo lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.
Download or read book Oncogenes and Human Cancer Blood Groups in Cancer Copper and Inflammation Human Insulin written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: l Tumor transformation produces numerous antigenic alterations ), particularly 2 among the glycoconjugates, sugars linked to each other, to lipids and to proteins , 3). Many blood group antigens are identified as glycoconjugates; they include the 4 ABO(H) , MNT, Lewis, Ii and P antigens ). These determinants are particularly valuable since they can be understood in terms of their serology, chemical structure and biochemical genetics4-7). Their specific functions are not well understood; how ever, their position as terminal or penultimate sugars may assign them a special role lO as protective or informational moleculesS- ). Ordinarily, these antigens, equally 4lO described on erythrocytes ), persist unchanged throughout the lifetime of the indi vidual, but they may be susceptible to alterations in the presence of certain hematopoietic diseases and solid tissue tumors, primarily carcinomas. A review of 11 this topic was published by one of us in 1980 ). New data has accumulated rapidly since then, particularly in the areas of structural analysis, biochemical genetics, and immunologic and tumor marker relationships. The purpose of this review is to provide an update of progress realized in these areas. Other reviews with emphasis 12 l5 on special areas are also available - ). Current and prospective experimental studies should be of use in regard to the following questions: 1.
