Download or read book Inflammation and Pregnancy written by Donald M. Peebles and published by CRC Press. This book was released on 2006-09-15 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowhere is the complex relation between inflammation and disease more apparent than in pregnancy. From the immune adaptation necessary for a mother to tolerate a genetically different fetus through gestation, to the role of inflammatory mediators in abnormalities of pregnancy such as pre-eclampsia and premature delivery, it is clear that inflammation plays a vital role in determining pregnancy outcome. In this authoritative text, an international panel of prestigious authors explores the complex relationship between inflammation, the mother, placenta and fetus. Providing comprehensive coverage by discussing both basic sciences and clinical applications, the book also ensures wide appeal by presenting a synthesis of the maternal and fetal aspects of immunological disorders in pregnancy. The only recent work on the subject in this fast-moving field, Inflammation and Pregnancy is relevant to a wide range of scientists and clinicians with an interest in inflammation, early pregnancy, placental development, pre-eclampsia, pre-term delivery and fetal/neonatal development.
Download or read book The Maternal Fetal Interface written by Anthony Carter and published by Boydell & Brewer. This book was released on 1998 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
Download or read book Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis written by Sandra Hellberg and published by Linköping University Electronic Press. This book was released on 2019-10-22 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
Download or read book Immunology of Pregnancy written by Gil Mor and published by Springer Science & Business Media. This book was released on 2007-12-27 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers in detail contemporary hypotheses and studies related to the immunology of implantation and provides a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR. Provides complete and up to date review of current knowledge of the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system.
Download or read book Malaria Immunology written by Peter Perlmann and published by Karger Medical and Scientific Publishers. This book was released on 2002-01-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Download or read book Building Babies written by Kathryn B.H. Clancy and published by Springer Science & Business Media. This book was released on 2012-08-27 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ontogeny of each individual contributes to the physical, physiological, cognitive, neurobiological, and behavioral capacity to manage the complex social relationships and diverse foraging tasks that characterize the primate order. For these reasons Building Babies explores the dynamic multigenerational processes of primate development. The book is organized thematically along the developmental trajectory:conception, pregnancy, lactation, the mother-infant dyad, broader social relationships, and transitions to independence. In this volume, the authors showcase the myriad approaches to understanding primate developmental trajectories from both proximate and ultimate perspectives. These collected chapters provide insights from experimental manipulations in captive settings to long-term observations of wild-living populations and consider levels of analysis from molecule to organism to social group to taxon. Strepsirrhines, New World monkeys, Old World monkeys, apes, and humans are all well-represented. Contributions by anthropologists, microbiologists, psychologists, population geneticists, and other primate experts provide Building Babies a uniquely diverse voice. Building Babies features multi- and trans-disciplinary research approaches to primate developmental trajectories and is particularly useful for researchers and instructors in anthropology, animal behavior, psychology, and evolutionary biology. This book also serves as a supplement to upper-level undergraduate courses or graduate seminars on primate life history and development. In these contexts, the book provides exposure to a wide range of methodological and theoretical perspectives on developmental trajectories and models how researchers might productively integrate such approaches into their own work.
Download or read book Innate Immunity in Normal and Adverse Pregnancy written by Jean F. Regal and published by Frontiers Media SA. This book was released on 2021-03-25 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Problems in Pregnancy written by Uri Elkayam and published by John Wiley & Sons. This book was released on 2019-09-02 with total page 1227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Problems in Pregnancy offers clinicians the most detailed and comprehensive guide to diagnosing and managing pregnancy-associated cardiovascular diseases currently available. Covering a wide spectrum of congenital and acquired cardiovascular conditions, its extensive contents examine diseases of the heart with an expert awareness of the implications of pregnancy and the attendant physiological changes it brings. Such guidance is vitally required in an age in which congenital and acquired heart diseases are the leading causes of non-obstetrical maternal morbidity and mortality. Featuring 36 new or extensively revised chapters, this fourth edition of the book complements coverage of the latest research and clinical advances with a complete and up-to-date bibliography of literature on pregnancy in women with cardiovascular conditions. It also serves as a practical, step-by-step companion for those caring for heart disease patients during pregnancy, labor, and the post-partum period. Contents include: Coverage of all elements of maternal cardiology Newly written chapters featuring fresh research and data Guidance on performing risk assessments and interventions both prior to and during gestation Explanations of a range of diagnostic and therapeutic approaches to cardiovascular disease in pregnant patients Drawing on expertise from across the fields of cardiovascular medicine, obstetrics, anesthesiology, cardiac surgery, pharmacology, and clinical science, Cardiac Problems in Pregnancy is designed to give invaluable support to all medical professionals involved in maximizing the safety and success of cardiologically complex pregnancies.
Download or read book Management of Inflammatory Bowel Disease written by Burton I. Korelitz and published by Mosby Elsevier Health Science. This book was released on 1992 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fetal Maternal Immune Interactions in Pregnancy written by Nandor Gabor Than and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Infections in Pregnancy written by Adel Elkady and published by Cambridge University Press. This book was released on 2019-10-24 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.
Download or read book Maternal Hemodynamics written by Christoph Lees and published by Cambridge University Press. This book was released on 2018-05-03 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover new concepts in cardiovascular and hemodynamic functionality in feto-maternal medicine, from leading experts in the field.
Download or read book Neurological Diseases and Pregnancy written by Emma Ciafaloni and published by Oxford University Press. This book was released on 2018 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: For a woman of reproductive age, any medical appointment is a pre-conception visit and an opportunity to address pre-existing conditions that affect pregnancy and the maternal-fetal dyad. However, many neurologic conditions are rarely seen in pregnancy, and limited experience and knowledge may prevent the team from developing a shared approach to these complex conditions during pregnancy. Neurological Diseases and Pregnancy: A Coordinated Care Model for Best Management brings together experts across the disciplines of maternal fetal medicine, neurology, obstetrics, family planning, genetics, anesthesia, psychiatry, neurosurgery, and lactation to provide a multi-disciplinary, comprehensive, protocol-driven guide on best care for patients with neurologic disease before, during and after pregnancy. Each chapter provides a detailed care map on each unique disorder, and discusses the use of neurological medications during pregnancy and in lactation. Through this multi-disciplinary approach clinicians can navigate the complexities of preconception and pregnancy care, and help to optimize outcomes for the mother-infant dyad. Beyond pregnancy care, this volume further serves as a resource on best care for the life-course of women affected by neurologic disease including pre-pregnancy planning, genetic counseling, contraception, and sexuality in neurologic disease, as well as post-partum depression and menopausal neurologic changes.
Download or read book Immunology of Pregnancy written by Udo R. Markert and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.
Download or read book A Proposal to Investigate the Roles of Maternal Inflammation and Diet in Associations of Maternal Paraben Concentrations with Gestational Length written by Diana C. Pacyga and published by . This book was released on 2021 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proposed research will fill a public health need by providing information about the roles inflammation and dietary interventions play in associations of maternal paraben concentrations with shorter gestation. Specifically, this study proposes to investigate the maternal inflammatory pathways linking parabens with shorter gestation, as well as the potential intervening effect of a maternal anti-inflammatory diet on shorter gestation in response to parabens. The central hypothesis is that higher paraben concentrations are associated with shorter gestation due to elevated maternal inflammation and that an anti-inflammatory maternal diet mitigates these relationships. The proposed study will test this central hypothesis in 482 pregnant women enrolled in the Illinois Kids Development Study (I-KIDS), which is an ongoing prospective pregnancy and birth cohort with the primary goal of evaluating the impacts of prenatal chemical exposures on infant neurodevelopment. The feasibility of testing these hypotheses has been determined by conducting several preliminary studies in a sub-sample of 294 I-KIDS women. Overall, findings from this study will inform future research and clinical practice about the biological targets of parabens during pregnancy and guide prenatal healthcare professionals to make effective dietary recommendations to their pregnant patients.
Download or read book Birth Settings in America written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-05-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The delivery of high quality and equitable care for both mothers and newborns is complex and requires efforts across many sectors. The United States spends more on childbirth than any other country in the world, yet outcomes are worse than other high-resource countries, and even worse for Black and Native American women. There are a variety of factors that influence childbirth, including social determinants such as income, educational levels, access to care, financing, transportation, structural racism and geographic variability in birth settings. It is important to reevaluate the United States' approach to maternal and newborn care through the lens of these factors across multiple disciplines. Birth Settings in America: Outcomes, Quality, Access, and Choice reviews and evaluates maternal and newborn care in the United States, the epidemiology of social and clinical risks in pregnancy and childbirth, birth settings research, and access to and choice of birth settings.
Download or read book Hypertension in Pregnancy written by Alexander Heazell and published by Cambridge University Press. This book was released on 2010-08-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertensive disorders are among the most common medical complications of pregnancy, with an incidence of approximately 6-10%. This spectrum of conditions includes essential hypertension, pre-eclampsia and HELLP syndrome. For patients with pre-existing hypertension, management ideally commences prior to conception, and continues through pregnancy to the postnatal period. This book provides information on the evidence-based management of women with hypertension throughout pregnancy, supported by important background information on the etiology, risk-factors and pathophysiology of these disorders. Illustrated with accompanying algorithms, tables and lists for quick reference on diagnostic criteria, drugs and side-effects, this book will help clinicians rapidly gain access to the information they need to care for these patients. This will to be of interest to all grades of obstetric trainees as well as specialists, obstetric anesthetists and anesthetic trainees, midwives and maternal-fetal physicians.
