Download or read book Inflammation and Epilepsy New Vistas written by Damir Janigro and published by Springer Nature. This book was released on 2021-05-18 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
Download or read book The chronic challenge new vistas on long term multisite contacts to the central nervous system written by Ulrich G. Hofmann and published by Frontiers Media SA. This book was released on 2015-06-19 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Have you ever heard of a Hype-Cycle? It is a description that was put forward by an IT consultancy firm to describe certain phenomena that happen within the life cycle of new technology products. As Fenn and Raskino stated in their book (Fenn and Raskino 2008), a novel technology - a “Technology Trigger” - gives rise to a steep increase in interest, leading to the “Peak of Inflated Expectations”. Following an accumulation of more detailed knowledge on the technology and its short-comings, the stake holders may need to traverse a “Trough of Disillusionment”, which is followed by a shallower “Slope of Enlightenment”, before finally reaching the “Plateau of Productivity”. In spite of the limitations and criticisms levied on this over-simplified description of a technology’s life-cycle, it is nonetheless able to describe well the situation we are all experiencing within the brain-machine-interfacing community. Our technology trigger was the development of batch-processed multisite neuronal interfaces based on silicon during the 1980s and 1990s (Sangler and Wise 1990, Campbell, Jones et al. 1991, Wise and Najafi 1991, Rousche and Normann 1992, Nordhausen, Maynard et al. 1996). This gave rise to a seemingly exponential growth of knowledge within the neurosciences, leading to the expectation of thought-controlled devices and prostheses for handicapped people in the very near future (Chapin, Moxon et al. 1999, Wessberg, Stambaugh et al. 2000, Chapin and Moxon 2001, Serruya, Hatsopoulos et al. 2002). Unfortunately, whereas significant steps towards artificial robotic limbs could have been implemented during the last decade (Johannes, Bigelow et al. 2011, Oung, Pohl et al. 2012, Belter, Segil et al. 2013), direct invasive intracortical interfacing was not quite able to keep up with these expectations. Insofar, we are currently facing the challenging, but tedious walk through the Trough of Disillusionment. Undoubtedly, more than two decades of intense research on brain-machine-interfaces (BMI’s) have produced a tremendous wealth of information towards the ultimate goal: a clinically useful cortical prosthesis. Unfortunately even today - after huge fiscal efforts - the goal seems almost to be as far away as it was when it was originally put forward. At the very least, we have to state that one of the main challenges towards a clinical useful BMI has not been sufficiently answered yet: regarding the long term – or even truly chronic – stability of the neural cortical interface, as well as the signals it has to provide over a significant fraction of a human’s lifespan. Even the recently demonstrated advances in BMI’s in both humans and non-human primates have to deal with a severe decay of spiking activity that occurs over weeks and months (Chestek, Gilja et al. 2011, Hochberg, Bacher et al. 2012, Collinger, Kryger et al. 2014, Nuyujukian, Kao et al. 2014, Stavisky, Kao et al. 2014, Wodlinger, Downey et al. 2014) and resolve to simplified features to keep a brain-derived communication channel open (Christie, Tat et al. 2014).
Download or read book Neuroinflammation in Acquired Epilepsy written by Jianxiong Jiang and published by Frontiers Media SA. This book was released on 2022-12-01 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases written by Rona R. Ramsay and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu
Download or read book Stress and Inflammation in Disorders written by and published by Academic Press. This book was released on 2017-04-17 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress and Inflammation in Disorders, the latest volume in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Features new information about protocols and analysis of proteins Contains chapters written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students
Download or read book Pathological Potential of Neuroglia written by Vladimir Parpura and published by Springer. This book was released on 2014-09-26 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathophysiological states, neurological and psychiatric diseases are almost universally considered from the neurocentric point of view, with neurons being the principal cellular element of pathological process. The brain homeostasis, which lies at the fulcrum of healthy brain function, the compromise of which invariably results in dysfunction/disease, however, is entirely controlled by neuroglia. It is becoming clear that neuroglial cells are involved in various aspects of initiation, progression and resolution of neuropathology. In this book we aim to integrate the body of information that has accumulated in recent years revealing the active role of glia in such pathophysiological processes. Understanding roles of glial cells in pathology will provide new targets for medical intervention and aide the development of much needed therapeutics. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.
Download or read book Pellock s Pediatric Epilepsy written by Douglas R. Nordli, Jr., MD and published by Springer Publishing Company. This book was released on 2016-08-28 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth edition, Pellock’s Pediatric Epilepsy: Diagnosis and Therapy remains the gold standard for diagnosis, treatment, classification, and management of childhood epilepsies. With over 100 distinguished contributors from world-leading epilepsy programs, the long-awaited new edition maintains the breadth and scope the book is known for while significantly updating the science, practice, and therapeutic strategies that continue to move the field forward. At the center of this new edition is the totally reorganized and expanded section on age-related syndromes. There is a major emphasis on new genetic-based classifications and the clinical implications for identifying and managing the various subtypes. New chapters devoted exclusively to Panayiotopoulos syndrome, myoclonic status epilepticus, and autosomal dominant focal epilepsies, among others, cover even more ground than the last edition. Brand-new chapters in the drug and diet section cover perampanel, ezogabine, and lacosamide, while the existing chapters on major medical treatments have been comprehensively updated to reflect the latest trials and studies. Other sections contain new chapters on genetics, non-invasive functional mapping, sleep issues for pediatric epilepsy patients, and more. With more than 80 chapters, Pellock’s Pediatric Epilepsy now contains a full discussion of the spectrum of epilepsy disorders, not just seizures. From basic mechanisms and epidemiology, through diagnosis and therapy, to quality of life issues, the new edition of this established reference covers every aspect of childhood epilepsy and will continue to be the definitive core text for all professionals involved in the field. New to the Fourth Edition: Every chapter thoroughly reviewed, revised, and updated Section on age-related syndromes completely reconfigured to align with new ILAE terminology and organization in classifying seizures and forms of epilepsy Major update on disease mechanisms and all treatments for epilepsy, including drugs Increased attention to special populations, including a heavily-updated chapter on the female epilepsy patient New final section covers the epilepsy spectrum, with new chapters on epilepsy and sleep, co-morbidities of childhood, behavioral influence of AEDs, and transitioning to adulthood
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1973 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Niedermeyer s Electroencephalography written by Donald L. Schomer and published by Lippincott Williams & Wilkins. This book was released on 2012-10-18 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on electroencephalography since 1982, Niedermeyer's Electroencephalography is now in its thoroughly updated Sixth Edition. An international group of experts provides comprehensive coverage of the neurophysiologic and technical aspects of EEG, evoked potentials, and magnetoencephalography, as well as the clinical applications of these studies in neonates, infants, children, adults, and older adults. This edition's new lead editor, Donald Schomer, MD, has updated the technical information and added a major new chapter on artifacts. Other highlights include complete coverage of EEG in the intensive care unit and new chapters on integrating other recording devices with EEG; transcranial electrical and magnetic stimulation; EEG/TMS in evaluation of cognitive and mood disorders; and sleep in premature infants, children and adolescents, and the elderly. A companion website includes fully searchable text and image bank.
Download or read book Models of Seizures and Epilepsy written by Asla Pitkänen and published by Academic Press. This book was released on 2017-06-14 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Download or read book Biochemical Basis of Functional Neuroteratology written by and published by Elsevier. This book was released on 1988-07-01 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Basis of Functional Neuroteratology
Download or read book Case Studies in Pain Management written by Alan David Kaye and published by Cambridge University Press. This book was released on 2014-10-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
Download or read book Drug Discovery written by Robert A. Maxwell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.
Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Download or read book An Anthropologist on Mars written by Oliver Sacks and published by Vintage. This book was released on 2012-11-14 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: To these seven narratives of neurological disorder Dr. Sacks brings the same humanity, poetic observation, and infectious sense of wonder that are apparent in his bestsellers Awakenings and The Man Who Mistook His Wife for a Hat. These men, women, and one extraordinary child emerge as brilliantly adaptive personalities, whose conditions have not so much debilitated them as ushered them into another reality.
Download or read book Treatment of Male Infertility written by J. Bain and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our insight into the mechanisms of the physiology of reproduction has experienced a swift and constant development these last few years. The advent of more sophisticated diagnostic methods and their relatively easy clinical application allow for the incorporation of that knowledge into the evaluation of the infertile couple. These facts, together with an obvious change in social psychology, have facilitated the development of different specialities dealing with the problems of infertility. It is now possible in medical centers all around the world to undertake a better disposition of the infertile husband to look for advice, to be studied, and treated. Confronted with this situation we are still unable to offer specific therapy in most cases; however, empirically based therapy abounds. Advances in therapy have not kept pace with our increased physio logical knowledge and improved diagnostic techniques. Patho physiological mechanisms and etiological factors in male infertility are largely unknown. This has significantly hampered both clinical evaluation and advances in treatment allowing for frequent non scientific therapeutic incursions into the armamentarium of the an drologist. Several factors have given birth to therapeutic "fashions", which are bound to survive as long as this state of lack of knowledge con tinues. For example, we may ask whether the treatment of varicocele constitutes a fashion? Though we accept the treatment of varicocele as the best available treatment of male infertility, we do not know its mechanism of action and so we cannot predict a therapeutic result.
Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing
