Download or read book Inexact Methods for the Chemical Master Equation with Constant Or Time varying Propensities and Application to Parameter Inference written by Khanh Ngoc Dinh and published by . This book was released on 2018 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex reaction networks arise in molecular biology and many other different fields of science such as ecology and social study. A familiar approach to modeling such problems is to find their master equation. In systems biology, the equation is called the chemical master equation (CME), and solving the CME is a difficult task, because of the curse of dimensionality. The goal of this dissertation is to alleviate this curse via the use of the finite state projection (FSP), in both cases where the CME matrix is constant (if the reaction rates are time-independent) or time-varying (if the reaction rates change over time). The work includes a theoretical characterization of the FSP truncation technique by showing that it can be put in the framework of inexact Krylov methods that relax matrix-vector products and compute them expediently by trading accuracy for speed. We also examine practical applications of our work in delay CME and parameter inference through local and global optimization schemes.
Download or read book NUREG CR written by U.S. Nuclear Regulatory Commission and published by . This book was released on 1977 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Probability written by Winfried K. Grassmann and published by Springer Science & Business Media. This book was released on 2000 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Great advances have been made in recent years in the field of computational probability. In particular, the state of the art - as it relates to queuing systems, stochastic Petri-nets and systems dealing with reliability - has benefited significantly from these advances. The objective of this book is to make these topics accessible to researchers, graduate students, and practitioners. Great care was taken to make the exposition as clear as possible. Every line in the book has been evaluated, and changes have been made whenever it was felt that the initial exposition was not clear enough for the intended readership. The work of major research scholars in this field comprises the individual chapters of Computational Probability. The first chapter describes, in nonmathematical terms, the challenges in computational probability. Chapter 2 describes the methodologies available for obtaining the transition matrices for Markov chains, with particular emphasis on stochastic Petri-nets. Chapter 3 discusses how to find transient probabilities and transient rewards for these Markov chains. The next two chapters indicate how to find steady-state probabilities for Markov chains with a finite number of states. Both direct and iterative methods are described in Chapter 4. Details of these methods are given in Chapter 5. Chapters 6 and 7 deal with infinite-state Markov chains, which occur frequently in queueing, because there are times one does not want to set a bound for all queues. Chapter 8 deals with transforms, in particular Laplace transforms. The work of Ward Whitt and his collaborators, who have recently developed a number of numerical methods for Laplace transform inversions, is emphasized in this chapter. Finally, if one wants to optimize a system, one way to do the optimization is through Markov decision making, described in Chapter 9. Markov modeling has found applications in many areas, three of which are described in detail: Chapter 10 analyzes discrete-time queues, Chapter 11 describes networks of queues, and Chapter 12 deals with reliability theory.
Download or read book Basic Econometrics written by Damodar Gujarati and published by . This book was released on 1986 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amber 2021 written by David A. Case and published by University of California, San Francisco. This book was released on 2021-06-13 with total page 959 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amber is the collective name for a suite of programs that allow users to carry out molecular dynamics simulations, particularly on biomolecules. None of the individual programs carries this name, but the various parts work reasonably well together, and provide a powerful framework for many common calculations. The term Amber is also used to refer to the empirical force fields that are implemented here. It should be recognized, however, that the code and force field are separate: several other computer packages have implemented the Amber force fields, and other force fields can be implemented with the Amber programs. Further, the force fields are in the public domain, whereas the codes are distributed under a license agreement. The Amber software suite is divided into two parts: AmberTools21, a collection of freely available programs mostly under the GPL license, and Amber20, which is centered around the pmemd simulation program, and which continues to be licensed as before, under a more restrictive license. Amber20 represents a significant change from the most recent previous version, Amber18. (We have moved to numbering Amber releases by the last two digits of the calendar year, so there are no odd-numbered versions.) Please see https://ambermd.org for an overview of the most important changes. AmberTools is a set of programs for biomolecular simulation and analysis. They are designed to work well with each other, and with the “regular” Amber suite of programs. You can perform many simulation tasks with AmberTools, and you can do more extensive simulations with the combination of AmberTools and Amber itself. Most components of AmberTools are released under the GNU General Public License (GPL). A few components are in the public domain or have other open-source licenses. See the README file for more information.
Download or read book Representation and Invariance of Scientific Structures written by Patrick Suppes and published by Stanford Univ Center for the Study. This book was released on 2002 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental reason for using formal methods in the philosophy of science is the desirability of having a fixed frame of reference that may be used to organize the variety of doctrines at hand. This book—Patrick Suppes's major work, and the result of several decades of research—examines how set-theoretical methods provide such a framework, covering issues of axiomatic method, representation, invariance, probability, mechanics, and language, including research on brain-wave representations of words and sentences. This is a groundbreaking, essential text from a distinguished philosopher.
Download or read book Human Health and Performance Risks of Space Exploration Missions written by Jancy C. McPhee and published by U. S. National Aeronautics & Space Administration. This book was released on 2009 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Delphi Method written by and published by . This book was released on 1975 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanotechnology Research Directions IWGN Workshop Report written by M. C. Roco and published by Springer Science & Business Media. This book was released on 2000-03-31 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents recent dramatic breakthroughs and prospects for even more important future developments in a wide variety of fields and applications of science and technology related to `nanotechnology', all involving the control of matter on the nanometer-length scale, that is, at the level of atoms, molecules, and supramolecular structures. As the twenty-first century unfolds, nanotechnology's impact on the health, wealth, and security of the world's people is expected to be at least as significant as the combined influences in this century of antibiotics, the integrated circuit, and human-made polymers. The book covers fundamental scientific issues for nanotechnology and reviews progress in the development of the necessary tools for nanotechnology research and applications (e.g. theory, modeling and simulation, experimental methods, and instruments such as scanning probe microscopes). It also surveys a wide variety of current and potential application areas of nanotechnology, including: dispersions, coatings, and large surface area structures; nanodevices, nanoelectronics, and nanosensors; materials science and applications of bulk nanostructured materials with novel properties; biology, medicine, and healthcare; and energy, chemicals, and environmental science. The book incorporates the views of leading experts from U.S. government, academia, and the private sector. It reflects the consensus reached at a workshop held in January 1999, and detailed in contributions submitted thereafter by members of the U.S. science and engineering community. It describes challenges that are posed and opportunities that are offered by nanotechnology and outlines the steps that must be taken in order for humanity to benefit from the advances that are envisioned. This emphasizes three crucial areas: developing a balanced research and development infrastructure, advancing critical research areas, and nurturing the scientific and technical workforce of the next century.
Download or read book Adhesion Science and Engineering written by and published by Elsevier. This book was released on 2002-11-14 with total page 2020 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mechanics of Adhesion shows that adhesion science and technology is inherently an interdisciplinary field, requiring fundamental understanding of mechanics, surfaces, and materials. This volume comprises 19 chapters. Starting with a background and introduction to stress transfer principles; fracture mechanics and singularities; and an energy approach to debonding, the volume continues with analysis of structural lap and butt joint configurations. It then continues with discussions of test methods for strength and constitutive properties; fracture; peel; coatings, the case of adhesion to a single substrate; elastomeric adhesives such as sealants. The role of mechanics in determining the locus of failure in bonded joints is discussed, followed by a chapter on rheology relevant to adhesives and sealants. Pressure sensitive adhesive performance; the principles of tack and tack measurements; and contact mechanics relevant to wetting and surface energy measurements are then covered. The volume concludes with sections on fibermatrix bonding and reinforcement; durability considerations for adhesive bonds; ultrasonic non-destructive evaluation of adhesive bonds; and design of adhesive bonds from a strength perspective. This book will be of interest to practitioners in the fields of engineering and to those with an interest in adhesion science.
Download or read book Foundations of Complex system Theories written by Sunny Y. Auyang and published by Cambridge University Press. This book was released on 1998 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzes approaches to the study of complexity in the physical, biological, and social sciences.
Download or read book Biofilms in Wastewater Treatment written by Stefan Wuertz and published by IWA Publishing. This book was released on 2003-04-30 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme of the book is the flow of information from experimental approaches in biofilm research to simulation and modeling of complex wastewater systems. Probably the greatest challenge in wastewater research lies in using the methods and the results obtained in one scientific discipline to design intelligent experiments in other disciplines, and eventually to improve the knowledge base the practitioner needs to run wastewater treatment plants. The purpose of Biofilms in Wastewater Treatment is to provide engineers with the knowledge needed to apply the new insights gained by researchers. The authors provide an authoritative insight into the function of biofilms on a technical and on a lab-scale, cover some of the exciting new basic microbiological and wastewater engineering research involving molecular biology techniques and microscopy, and discuss recent attempts to predict the development of biofilms. This book is divided into 3 sections: Modeling and Simulation; Architecture, Population Structure and Function; and From Fundamentals to Practical Application, which all start with a scientific question. Individual chapters attempt to answer the question and present different angles of looking at problems. In addition there is an extensive glossary to familiarize the non-expert with unfamiliar terminology used by microbiologists and computational scientists. The colour plate section of this book can be downloaded by clicking here. (PDF Format 1 MB)
Download or read book Retailing in the 21st Century written by Manfred Krafft and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: With crisp and insightful contributions from 47 of the world’s leading experts in various facets of retailing, Retailing in the 21st Century offers in one book a compendium of state-of-the-art, cutting-edge knowledge to guide successful retailing in the new millennium. In our competitive world, retailing is an exciting, complex and critical sector of business in most developed as well as emerging economies. Today, the retailing industry is being buffeted by a number of forces simultaneously, for example the growth of online retailing and the advent of ‘radio frequency identification’ (RFID) technology. Making sense of it all is not easy but of vital importance to retailing practitioners, analysts and policymakers.
Download or read book Carbohydrates in Food written by Ann-Charlotte Eliasson and published by CRC Press. This book was released on 1996-01-02 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers comprehensive coverage of the chemical analysis, structure, functional properties and nutritional relevance of monosaccharides, disaccharides and polysaccharides used in food. It presents current information on the significance of carbohydrates in diet, and furnishes both chemical and biochemical methods for carbohydrate analysis.
Download or read book Low Back Disorders written by Stuart McGill and published by Human Kinetics. This book was released on 2007 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of 'Low Back Disorders' provides research information on low back problems and shows readers how to interpret the data for clinical applications.
Download or read book Quantum Chemistry in the Age of Machine Learning written by Pavlo O. Dral and published by Elsevier. This book was released on 2022-09-16 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantum chemistry is simulating atomistic systems according to the laws of quantum mechanics, and such simulations are essential for our understanding of the world and for technological progress. Machine learning revolutionizes quantum chemistry by increasing simulation speed and accuracy and obtaining new insights. However, for nonspecialists, learning about this vast field is a formidable challenge. Quantum Chemistry in the Age of Machine Learning covers this exciting field in detail, ranging from basic concepts to comprehensive methodological details to providing detailed codes and hands-on tutorials. Such an approach helps readers get a quick overview of existing techniques and provides an opportunity to learn the intricacies and inner workings of state-of-the-art methods. The book describes the underlying concepts of machine learning and quantum chemistry, machine learning potentials and learning of other quantum chemical properties, machine learning-improved quantum chemical methods, analysis of Big Data from simulations, and materials design with machine learning. Drawing on the expertise of a team of specialist contributors, this book serves as a valuable guide for both aspiring beginners and specialists in this exciting field. Compiles advances of machine learning in quantum chemistry across different areas into a single resource Provides insights into the underlying concepts of machine learning techniques that are relevant to quantum chemistry Describes, in detail, the current state-of-the-art machine learning-based methods in quantum chemistry
Download or read book Knowledge and Critical Pedagogy written by Joe L. Kincheloe and published by Springer Science & Business Media. This book was released on 2008-06-19 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a globalized neo-colonial world an insidious and often debilitating crisis of knowledge not only continues to undermine the quality of research produced by scholars but to also perpetuate a neo-colonial and oppressive socio-cultural, political economic, and educational system. The lack of attention such issues receive in pedagogical institutions around the world undermines the value of education and its role as a force of social justice. In this context these knowledge issues become a central concern of critical pedagogy. As a mode of education that is dedicated to a rigorous form of knowledge work, teachers and students as knowledge producers, anti-oppressive educational and social practices, and diverse perspectives from multiple social locations, critical pedagogy views dominant knowledge policies as a direct assault on its goals. Knowledge and Critical Pedagogy: An Introduction takes scholars through a critical review of the issues facing researchers and educators in the last years of the first decade of the twenty-first century. Refusing to assume the reader’s familiarity with such issues but concurrently rebuffing the tendency to dumb down such complex issues, the book serves as an excellent introduction to one of the most important and complicated issues of our time.
