Download or read book Inducible Enzymes in the Inflammatory Response written by Willoughby and published by Springer. This book was released on 2013-03-11 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con flicting statements in a number of the chapters. We believe that this is entirely appro priate as this volume reflects the latest work in a rapidly developing area.
Download or read book Inducible Enzymes in the Inflammatory Response written by D. A. Willoughby and published by Birkhauser. This book was released on 1999 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book brings together overviews by leading researchers in the field of the current status of knowledge of COX, NOS and HO in inflammation. These overviews cover a series of new concepts in the mechanism of inflammation. Topics include inducible enzyme involvement in inflammatory processes including the role in vascular permeability, leukocyte migration, granuloma formation, angiogenesis, neuroinflammation and algesia. New findings from transgenic animal models are reviewed. Other chapters address the importance of these enzymes in inflammatory disease states including rheumatoid arthritis, atherosclerosis and multiple sclerosis. The possibility of selective inhibitors or inducers of COX, NOS and HO, and their use in the clinic is discussed. The subject matter of this book is of interest to rheumatologists, pathologists, pharmacologists, neuroscientists and anyone with an academic interest in the mechanisms of inflammation.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fatty Acids and Inflammatory Skin Diseases written by Jens-Michael Schröder and published by Springer Science & Business Media. This book was released on 1999 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines the two major functions of fatty acids in skin biol ogy. Fatty acids play an important role in the barrier function of ski n and represent a major source of proinflammatory mediators such as pr ostaglandins, leukotrienes and other lipids in inflammatory skin disor ders (e.g. proinflammatory eicosanoids which play a role in psoriasis and a topic dermatitis). The pharmacological inhibition of eicosanoid biosynthesis is also reviewed.
Download or read book Proteases New Perspectives written by Vito Turk and published by Birkhäuser. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.
Download or read book Pain and Neurogenic Inflammation written by S.D. Brain and published by Springer. This book was released on 2013-03-11 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is intended to bring together recent advances in the often separate fields of pain and neurogenic inflammation. To this end, eminent researchers from both domains have contributed in-depth discussion of the mechanisms underlying these processes. Individual chapters focus on important recent discoveries such as the cloning of the capsaicin receptor and the discovery of RAMP proteins for CGRP receptors. This book provides an integrated account of recent advances in the fields of pain and neurogenic inflammation. The volume is intended to bring together studies from eminent researchers in the often separate research fields of pain and inflammation. "Pain and Neurogenic Inflammation" is aimed primarily at postgraduate researchers as well as academic and industrial researchers in pain and inflammation but is also likely to be of interest to undergraduate students seeking a firm grounding in the mechanisms underlying these important clinical conditions.
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer Science & Business Media. This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
Download or read book Immunomodulatory Agents from Plants written by Wagner and published by Birkhäuser. This book was released on 2012-12-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human immune system, despite having its own sophisticated defence mecha nisms, is inferior to bacteria and viruses with respect to adaptability. Furthermore, our immune system is increasingly exposed to detrimental effects, that is immuno suppressive environmental consequences, unhealthy living, and chronic illnesses. Excessive chemotherapy threatens our immune system even further. This situation demands compensatory prophylactic therapeutic regimes. One of these - specific immunostimulation - is more difficult to achieve than the immunosuppression cur rently used in transplantation surgery and the medical treatment of autoimmune dis eases. The earliest attempts to develop suitable medication for immunostimulation were based on traditional remedies which embodied the accumulated experience of several centuries. Medicinal plants are already being used prophylactically as stan dardized and efficacy-optimized preparations for the treatment of various recur rent infections, or in combination with chemotherapeutics in standard medical practice. In order to rationally apply immunostimulants of plant origin, however, it is necessary to search for the active principles of these substances and to produce them in a pure form. Because suitable screening methods have become available only recently, research in this field is in its very beginning. Further progress can be expected from systematic basic research on the mechanisms underlying immunomodulation. This also applies to verification of clinical efficacy, which is a prerequisite for the acceptance of medications with purported immunostimulatory properties.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Molecular Basis of Health and Disease written by Undurti N. Das and published by Springer Science & Business Media. This book was released on 2011-04-02 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
Download or read book Medicinal Fatty Acids in Inflammation written by J. Kremer and published by Springer. This book was released on 2013-03-11 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Inflammation Research is a unique compilation of work performed by a wide spectrum of investigators from different medical disciplines. It is fascinating that dietary alterations of fatty acid intake can result in a range of salutory changes in a great variety of medical conditions. Most of the good scien tific work which has led to these observations has been performed over just the last two decades. This is of course not a very long time in the context of the history of the human species. Recently performed analysis of fat intake from paleolithic times has indicated that our hunter-gatherer ancestors consumed as much cholesterol as modern Western man, but strikingly less saturated fatty acid and more polyunsatu rates, including n-3 fatty acids. Wild game has the terrestrial source of n-3 incorpo rated in its fat since browsing animals derive 18:3n-3 (alpha-linolenic acid) natural ly from leafy plants. There is, however, little opportunity for modern Western man to get n-3 fatty acids from the diet if one does not consume fish. Modern agribusiness provides ani mal feeds high in n-6 fatty acids, mostly derived from linoleic acid (18:2n-6) in corn feed. Therefore, grazing animals have no access to alternative fatty acids in either feed or grasses, the latter containing little or none of these potentially beneficial highly polyunsaturated fatty acids.
Download or read book Improved Non Steroid Anti Inflammatory Drugs COX 2 Enzyme Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.
Download or read book Radicals for Life written by Ernst van Faassen and published by Elsevier. This book was released on 2011-10-13 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases
Download or read book Nitric Oxide Synthase Characterization and Functional Analysis written by and published by Academic Press. This book was released on 1996-09-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution
Download or read book Angiogenesis in Inflammation Mechanisms and Clinical Correlates written by Michael Seed and published by Springer Science & Business Media. This book was released on 2008-11-14 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This much-needed text develops current knowledge on the mechanisms of angiogenesis at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.
Download or read book Therapeutic Targets in Airway Inflammation written by N. Tony Eissa and published by CRC Press. This book was released on 2003-05-13 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Download or read book Hot Topics in Burn Injuries written by Selda Pelin Kartal and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to give readers a broad review of burn injuries, which may affect people from birth to death and can lead to high morbidity and mortality. The book consists of four sections and seven chapters. The first section consists of the introductory review chapter, which overviews the burn injuries. The second section includes chapter "Burn Etiology and Pathogenesis," which focuses on burn injuries and clinical findings. The third section consists of chapter "Controlling Inflammation in Burn Injury" and is devoted to the role of inflammatory response, which is fundamental to the healing process, while a prolonged inflammation may lead to scarring and fibrosis. The fourth section consists of four chapters as follows: "Therapeutic Effects of Conservative Treatments on Burn Scars," "Herbal Therapy for Burns and Burn Scars," "Platelet-Rich Plasma in Burn Treatment," and "Surgical Treatment of Burn Scars." The book is easy to read and includes hot topics on burn injury to enhance the reader's understanding and knowledge.
