Download or read book Induced Effects Of Genotoxic Agents In Eukaryotic Cells written by Toby G Rossman and published by CRC Press. This book was released on 2020-07-26 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.
Download or read book Genotoxicity Assessment written by Alok Dhawan and published by Humana Press. This book was released on 2013-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Download or read book Genotoxicity written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2018-07-11 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to provide an overview of the different genotoxicants and their effects on living organisms, including humans. The contributions made by the specialists in this field of research are gratefully acknowledged. We hope that the information presented in this book will meet the expectations and needs of all those interested in the different aspects of the genotoxicity field. The publication of this book is of great importance to those scientists, pharmacologists, physicians and veterinarians, as well as engineers, teachers, graduate students and administrators of environmental programmes, who make use of these investigations to understand both the basic and applied genotoxic aspects of known and new xenobiotics, and to guide them in their future investigations.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Mutagenicity Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 489 In Vivo Mammalian Alkaline Comet Assay written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Plant Mutation Breeding and Biotechnology written by Q. Y. Shu and published by CABI. This book was released on 2012 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book covers the underlying scientific principles, state-of-the-art technologies and methodologies of plant mutagenesis. It covers historical development and commonly used terminologies, chemical and physical mutagenesis, mutation induction, mutation breeding and mutations in functional genomics research. Suitable both as a manual for professionals and a resource for students in plant breeding and research, the book includes exemplary cases of practical applications and an appendix of recommended doses of gamma and fast neutron irradiation for almost 200 plant species. It is
Download or read book Biomarkers in Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2014-01-25 with total page 1149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more
Download or read book Photobiology in Medicine written by Giulo Jori and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Man has recognised an association of light with life and medicine for over 3000 years. Today the major challenges to this topic include the elucidation of photochemical reactions involved in photobiology at the molecular level. This includes the use of a variety of modem probing techniques that directly measures the reactivity of excited states and free radicals involved in biological reactions. This text-book is based on such an approach and has arisen from some of the lectures delivered at the NATO ASI held at Hotel Capo Caccia near the Centre for Advanced Research in Photobiology (CARP) in Sardegia, Italy. The ASI took place from 30 September -13 October 1993 and involved a total membership of 90. The book, like the NATO ASI itself, is divided into four themes starting with fundamental aspects and ending with complex medically related systems. Thus Theme 1 covers aspects of the underlying photophysics and photochemistry with particular emphasis on modem experimental techniques to study molecular mechanisms of biological processes. Theme 2 applies many of these fundamental studies to the chemical reactions of most relevance to photobiology and photomedicine such as photo-addition, -isomerization, -sensitization and -pigmentation. The third and fourth Themes deal with the deleterious and therapeutic aspects of light with particular emphasis on the use of Photo-Dynamic Therapy (PDT) to treat cancer and on viral and micro bioi infections.
Download or read book Molecular Biology written by G.P. JEYANTHI and published by MJP Publisher. This book was released on 2019-06-07 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Material Chemistry of Deoxyribonucleic Acid Structural Features of Deoxyribonucleic Acid Properties of Deoxyribonucleic Acid Prokaryotic and Eukaryotic Chromosomes Replication and Repair of Deoxyribonucleic Acid Ribonucleic Acid and TranscriptionThe Genetic Code Mutations and Molecular Mechanism of Mutagenesis Translation Regulation of Gene Expression in Prokaryotes Regulation of Gene Expression in Eukaryotes Analytical Techniques used in the Study of Nucleic Acids
Download or read book Biochemical and Biological Effects of Organotins Title Page pdf 02 Title Page 03 REVISED eBooks End User License Agreement Website 04 Prof Nagy memorial 05 Contents Index 06 Foreword 07 Preface 08 List of contributors 09 ABBREVIATION LIST OF ORGANOTINS 10 Chapter 1 ready KW 11 Chapter 2 ready KW revised 12 Chapter 3 ready KW 13 Chapter 4 ready KW 14 Chapter 5 ready KW 15 Chapter 6 ready KW revised 16 Chapter 7 ready KW 17 Chapter 8 ready KW revised 18 Chapter 9 ready KW 19 Chapter 10 ready KW revised 20 Chapter 11 ready KW 21 Chapter 12 ready KW 22 Index written by Alessandra Pagliarani and published by Bentham Science Publishers. This book was released on 2012 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effec.
Download or read book The Cellular Response to the Genotoxic Insult written by Helmut Greim and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk.
Download or read book Basic Clinical Radiobiology written by Michael C. Joiner and published by CRC Press. This book was released on 2018-08-28 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on success and reputation of previous editions Draws on the considerable teaching experience of an international author team, most notably the US and European Editors The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US Highly illustrated with new, 2 colour illustrations Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing written by and published by . This book was released on 1994 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
