Download or read book In Vivo Studies of the Kaposi s Sarcoma Associated Herpesvirus KSHV written by Sarah Kistler Turner and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research on Kaposi s sarcoma associated herpesvirus past present and future written by Keiji Ueda and published by Frontiers E-books. This book was released on with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been 16 years since Kaposi's sarcoma-associated herpesvirus (KSHV) was found from Kaposi's sarcoma. Very extensive studies on KSHV have been performed and we now know well that KSHV is actually the very etiologic agent to cause Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease and this virus is an oncogenic DNA virus in such sense. Though a lot of reports have been published, there are lots of enigmas on its epidemiology, entry, lytic replication/induction, viral particle assembly/egress, latency, oncogenesis and so on. At this time point, it is better for us to review what we learned from the studies of this virus and consider what we have to clarify about this virus nature for future by comparing the virus with the other virus research.
Download or read book Kaposi Sarcoma Herpesvirus New Perspectives written by Chris Boshoff and published by Springer Science & Business Media. This book was released on 2006-10-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: will follow
Download or read book In Vivo Studies of the Kaposi s Sarcoma associaterd Herpesvirus KSHV written by Sarah Kistler Turner and published by . This book was released on 2001 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV AIDS Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.
Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Kaposi Sarcoma New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Kaposi Sarcoma in a concise format. The editors have built Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Kaposi Sarcoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book An in Vitro Model to Study Kaposi s Sarcoma associated Herpesvirus in B cells written by Semra Kati and published by . This book was released on 2012 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kaposi Sarcoma New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi Sarcoma: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Kaposi Sarcoma in a concise format. The editors have built Kaposi Sarcoma: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Kaposi Sarcoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Kaposi Sarcoma: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book In Vitro Analysis of the Impact of Kaposi s Sarcoma associated Herpesvirus KSHV on Experimentally Induced Necroptosis written by Vinay Murtadak and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Retrovirus Protocols written by Tuofu Zhu and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of basic and state-of-the-art methods optimized for investigating the molecular biology of this class of retrovirus. These readily reproducible techniques range from methods for the isolation and detection of human retroviruses to cutting-edge methods for exploring the interplay between the viruses and the host. Here, the researcher will find up-to-date techniques for the isolation and propagation of HIV, HTLV, and foamy virus from a variety of sources. There are also assays for determining the cell tropism of HIV-1, the coreceptor usage of HIV-1, and human gene expression with HIV-1 infection by microarrays, as well as for phenotyping HIV-1 infected monocytes and examining their fitness. Highlights include the detection and quantification of HIV-1 in resting CD4+, a new cloning system for making recombinent virus, cDNA microarrays, and the determination of genetic polymorphisms in two recently identified HIV-1 co-factors that are critical for HIV-1 infection.
Download or read book Herpesvirus Latency written by Benedikt B. Kaufer and published by Frontiers Media SA. This book was released on 2020-09-14 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Kaposi s Sarcoma associated Herpesvirus Replication and Transcription Activator Regulates Extracellular Matrix Signal Pathway written by Daniel Pfalmer and published by . This book was released on 2016 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi’s Sarcoma (KS) is a malignancy caused by infection with Kaposi’s Sarcoma-associated Herpesvirus [KSHV; also known as Human Herpesvirus 8 (HHV8)] in which tumor cells show a characteristic ‘spindle-like’ morphology. The transcription factor RTA (Replication and Transcription Activator) is the viral protein responsible for reactivating KSHV from its latent state. Production of RTA in latently infected cells causes a number of viral proteins to be produced and leads to a cascade of gene expression changes in both viral and host genes. Previous work in our lab showed that RTA was capable of reprogramming cells in vitro to display a spindle-like morphology. In this study we aimed to identify the host gene expression changes caused directly by RTA which could be responsible for that reprogramming. To that end, Madin-Darby Canine Kidney cells (MDCK cells) were chosen as a model for KSHV-naïve mammalian cells. Differences in host gene expression levels in a culture of MDCK cells transfected with a plasmid coding for expression of RTA compared to MDCK cells transfected with a similar plasmid lacking the RTA gene were measured by whole transcriptome sequencing (RNA-Seq). Cells containing the RTA-coding plasmid adopted a spindle-like morphology and showed at least a two-fold change in expression level in approximately 180 genes. Those 180 genes were then screened for known associations to signaling pathways in order to determine which might be involved with the morphological changes observed and/or biological significance. The expression levels of the 10 genes identified by that screening were then verified by quantitative real time PCR (qPCR). Of those 10 genes, eight were identified as potentially associated with the morphological changes, including three genes associated with extra cellular matrix (ECM) destruction (MMP9, CTSD, and CTSS) that were down-regulated; two genes associated with blocking ECM destruction (TIMP1 and TIMP2) that were pregulated; two ECM component genes (LAMC2 and COL1A2) that were upregulated; and one gene associated with blocking cell-cell and cell-ECM adhesion (MUC1) that was downregulated. The remaining two genes (MAP2K1 and podoplanin) were identified as potentially biologically significant, but not directly involved in regulating morphology. MAP2K1 is associated with epithelial dedifferentiation and was down-regulated; and the lymphatic endothelial specific marker podoplanin (PDPN) was up-regulated. Taken together, the differences in morphology and gene expression between RTA-producing cells and controls suggest a possible role for RTA in the formation of the spindle cells that characterize Kaposi’s sarcoma.
Download or read book Human Herpesviruses written by Yasushi Kawaguchi and published by Springer. This book was released on 2018-06-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.
Download or read book Within host Diversity of Kaposi Sarcoma associated Herpesvirus written by Jan Clement Ang Santiago and published by . This book was released on 2021 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi sarcoma (KS) is a progressive, incurable soft tissue disease that is the most common cancer of men in regions of sub-Saharan African and the second most common among people with HIV. Kaposi Sarcoma-associated Herpesvirus (KSHV) is the infectious cause of KS, but why only a small fraction of those infected develop KS is not understood. Immune status, viral co-infection, host genetics and environmental factors all are likely to play a role. My thesis sought to identify a possible viral genetic component of KS, through an analysis of the diversity of whole KSHV genomes within individuals afflicted by KS. Strain variation or de novo mutations occurring in other oncoviruses have been associated with variations in disease risk, disease manifestation and clinical course. These variations have the potential to become diagnostic biomarkers and help reveal insights into the pathogenicity of the virus. To identify potential tumor-associated mutations in KSHV I analyzed the ~131 kb unique sequence regions of 43 whole KSHV genomes from tumors and oral swabs from 22 individuals and then screened additional tumors by targeted sequencing and ddPCR to better assess the frequency of identified mutations. In total, 65 KS tumors and 18 oral swabs were evaluated from a cohort of 30 study participants with KS, all from the Uganda Cancer Institute. In addition, the major internal repeat regions of the KSHV genome were examined from 16 individuals. The newly developed technologies of duplex Unique Molecular Identifier (dUMI) and single molecule real time sequencing with UMI (SMRT-UMI) were employed to provide an unprecedented accuracy and depth of study of herpesvirus populations within individuals. These studies revealed recurring tumor-associated mutations, specifically an overrepresentation of a specific region encompassing the K5 and K6 genes and inactivating mutations in the K8.1 gene, both of which were found in at least a third of the cohort and had associations with late-stage tumor characteristics. In contrast, the translation potential of full-length Kaposin proteins from IR2 was lost in a majority of individuals, but no tumor association or clinical correlate was identified. Rearrangement breakpoints were sometimes shared between different tumors from the same person, indicating spread by metastases, helper viruses or residual infectivity. In summary, these studies revealed the presence of selection for tumor- and clinical-stage specific changes the KSHV genome. Hypotheses on whether these changes play a role in KS tumor formation, immune evasion and driving persistence in the host are put forth along with proposed experiments to test them. Among them, findings from my thesis suggest that targeted screening of the K5-K6 and K8.1 gene regions can be helpful in tumor classification.
Download or read book Epigenetics of Infectious Diseases written by Walter Doerfler and published by Springer. This book was released on 2017-05-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.
