Download or read book Impact of Circulating Tumor DNA ctDNA in Patients with Gastrointestinal Malignancies written by Pashtoon Murtaza Kasi and published by Frontiers Media SA. This book was released on 2020-12-18 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Pathological Specimens and Genomic Medicine written by Michael R. Emmert-Buck and published by . This book was released on 2019 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Download or read book Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer written by Michail Ignatiadis and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.
Download or read book Advances in the Molecular Understanding of Colorectal Cancer written by Eva Segelov and published by BoD – Books on Demand. This book was released on 2019-02-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Liquid Biopsy in Cancer Patients written by Antonio Russo and published by Humana Press. This book was released on 2017-07-26 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.
Download or read book Liquid Biopsies in Solid Tumors written by Massimo Cristofanilli and published by Humana. This book was released on 2018-05-08 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.
Download or read book Molecular Diagnostics in Cancer Patients written by Kamla Kant Shukla and published by Springer. This book was released on 2019-03-15 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Download or read book The Economics of Cancer Care written by Nicholas Bosanquet and published by Cambridge University Press. This book was released on 2006-03-23 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2006 book examines the interaction of economics and the delivery of cancer care in the global context. It analyses the causes of tension between those paying for care, those providing the care and those marketing drugs and devices. The concept and requirement for rationing is examined in different economic environments. As cancer increases in incidence and prevalence, the economics of providing care becomes a more important subject than ever before. Written by a leading health economist and oncologist, this was the first comprehensive book on the economics of cancer care continues to be of interest to health professionals and policy makers alike.
Download or read book Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2020-07-21 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
Download or read book Colorectal Cancer Screening written by Joseph Anderson, MD and published by Springer Science & Business Media. This book was released on 2011-04-23 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.
Download or read book Staging Laparoscopy written by P. Hohenberger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.
Download or read book Leukemia and Lymphoma written by Theodore F. Zipf and published by Springer Science & Business Media. This book was released on 2003 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The techniques range from the use of patient-specific immunophenotypes to identify residual leukemia in patients who are in remission, to a variety of PCR techniques for detecting residual disease and measuring its level. Reverse transcription PCR (RT-PCR) is applied to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for non-Hodgkin's lymphoma and for the monitoring of follicular lymphoma.
Download or read book Molecular Cytopathology written by Bin Yang and published by Springer. This book was released on 2016-08-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications of molecular tools in cytopathology and provides a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different subspecialities of diagnostic pathology. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in liquid-based cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.
Download or read book The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology written by Martha Bishop Pitman and published by Springer. This book was released on 2015-05-30 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text and the terminology developed by the Papanicolaou Society of Cytopathology (P.S.C.) represents an important advance in the field of pancreaticobiliary cytopathology. This textbook/atlas is designed to present a comprehensive and state of the art approach to the cytologic diagnosis and reporting of pancreaticobiliary lesions. Chapters address each of the diagnostic categories defined by the P.S.C. The definition of each category along with the clinical pathologic entities contained within the category are discussed along with specific cytologic criteria for inclusion of a cytologic specimen within the category. Each chapter is lavishly illustrated demonstrating diagnostic criteria and examples of lesions contained within the category. Additionally, appropriate ancillary testing is discussed and where appropriate illustrated. Each chapter concludes with a discussion of appropriate management as well as estimates of malignancy risk for the category. The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria, Ancillary Testing and Management will provide the reader with a unified approach to diagnosing and reporting interpretations of cytologic specimens obtained from the pancreaticobiliary tract. This text/atlas will serve as a reference guide for pathologists, surgeons, endoscopists and radiologists.
Download or read book Awakening the Witch written by Cian Brown and published by America Star Books. This book was released on 2011-09 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Awakening the Witch is filled with the secrets that were, until now, only taught to chosen students...techniques not seen in any other book. Whether you are new to the Craft or have been practicing for some time, you will be using Awakening the Witch for many years to come. Get back to the heart of magick, a marriage of science and art. With simple how-to's, first-hand stories, spells, rituals, and creative exercises, you too will awaken the Witch within you. Easy-to-follow instructions for circle-casting, calling the powers, creating spells that work and more How to make and use the tools of Witchcraft: Wand, Athame, Chalice and Pentacle Understand how to do rituals, including the powerful rite of self-initiation Learn the true meaning of the Wiccan Rede Make a Magick Mirror and learn to interpret omens
