Download or read book Immunomodulatory Biomaterials written by Stephen F. Badylak and published by Woodhead Publishing. This book was released on 2021-07-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Download or read book Biomaterials and Immune Response written by Nihal Engin Vrana and published by CRC Press. This book was released on 2018-07-20 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Download or read book Biomaterials in Regenerative Medicine and the Immune System written by Laura Santambrogio and published by Springer. This book was released on 2015-09-04 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Download or read book Recent Advancements of Immunomodulatory Biomaterials in Cell Therapy and Tissue Engineering written by Sudip Mukherjee and published by Springer. This book was released on 2024-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.

Download or read book The Immune Response to Implanted Materials and Devices written by Bruna Corradetti and published by Springer. This book was released on 2016-11-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Download or read book Immunomodulatory Biomaterials and Nano immunotherapies written by Thomas J Webster and published by Woodhead Publishing. This book was released on 2025-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunomodulatory Biomaterials and Nano-immunotherapies reviews the general cellular and biochemical barriers of the tumor microenvironment and other immune diseases, the ways they are addressed by modern immunotherapies, and the specific barriers facing particular immunotherapeutic approaches. The latest research on immunomodulatory biomaterials is examined, providing a perspective on their future opportunities in modulating disease treatment strategies. Translational considerations and lessons learned from the various components of nanotechnology-enabled immunotherapies, including conventional immunotherapies, nucleic acids, nanotechnology, and biotechnology-based therapeutics are assessed. Finally, a framework for the development of the next generation of nanotechnology-enabled immunotherapies is detailed, providing guidance and suggestions for those interested in the development of novel immunomodulatory nanobiomaterials. Immunomodulatory Biomaterials and Nano-immunotherapies is a key reference for researchers and developers working in biomaterials, nanotechnology, immunology, biomedical engineering and pharmaceutical sciences.

Download or read book Immunomodulatory Biomaterials to Mitigate Material induced Host Responses written by Yoon Kyung Kim and published by . This book was released on 2013 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foreign body response to biomaterial implants has been a major challenge in translating many medical devices into the clinic. The presence of inflammatory cells around the implanted device prevents its functional interaction with the surrounding tissue, and although some inflammation may be desirable to mediate the healing process, a persistent inflammatory response will eventually lead to device failure. Significant efforts to reduce foreign body response have been largely focused on developing hydrophilic and anti-fouling coating materials, however, simply preventing protein adsorption and immune cell adhesion has only had moderate success at reducing inflammation in vivo. In this thesis, we describe a novel approach to mitigate the foreign body response, whereby materials are designed to mimic host tissue by displaying endogenously expressed immunomodulatory molecules that interact with specific inhibitory receptors expressed on immune cells. More specifically, biomaterial surfaces are coated with the recombinantly produced immunomodulatory molecule, CD200, which interacts with the inhibitory receptor CD200R on myeloid cells, preventing material-induced host response by suppressing activation of infiltrated myeloid cells. In Chapter One, a brief introduction and background information is presented, followed by a description of the production and purification of recombinant CD200 protein from both mammalian cells and bacterial cells in Chapter Two. In Chapter Three, we examine whether immobilization of CD200 onto polystyrene surfaces influences on suppressing the activation of macrophages. We found that CD200 indeed suppresses the release of inflammatory mediators secreted by macrophage cells in vitro, and elicited less inflammation in vivo when compared to uncoated materials after subcutaneous implantation. In Chapter Four, we examine whether CD200 influences tissue regeneration after spinal cord injury. CD200-embedded fibrin gel was implanted to spinal cord injured mice, and the effect of CD200 on inflammation and regenerative process was examined. Lastly, Chapter Five concludes the work performed in this Ph.D. study and presents future directions. This work suggests that coating of endogenously expressed immunomodulatory proteins can be used as a strategy to reduce inflammatory response to biomaterials and may potentially be generalized to implants throughout the body.

Download or read book Host Response to Biomaterials written by Stephen F. Badylak and published by Academic Press. This book was released on 2015-05-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Download or read book Handbook of Biomaterials for Medical Applications Volume 2 written by Deepa Suhag and published by Springer Nature. This book was released on with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunomodulatory Effects of Nanomaterials written by Mahmoud Elsabahy and published by Woodhead Publishing. This book was released on 2022-06-02 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluative and analytical methods for assessing effects. Sections cover a range of common nanomaterials for biomedical use and how different properties can elicit varied responses from the immune system. The immunomodulatory effects of these materials are then discussed, with coverage on adverse and/or toxic effects on the immune system, as well as desired modulatory effects to improve efficacy of applied therapeutics. Readers will also learn about the best evaluation methods for immunomodulatory effects of nanomaterials and associated risks. This book is a useful reference for academics and researchers with an interest in immunology, but it is also idea for those working in the fields of materials science, biomedical engineering, pharmaceutical science, immunology and toxicology. Details a range of common nanomaterials and how their specific properties and characteristics interact with the immune system Discusses the immunomodulatory effects of nanomaterials, from unintentional and potentially harmful, to intentional and desired effects on the immune system Explores methods for evaluation of immunomodulatory effects of nanomaterials, as well as precautions and risks for data analysis and interpretation

Download or read book Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies written by Amanda L. Facklam and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials are used in a variety of therapeutics including vaccines, engineered tissues, and cell therapies. Biomaterials enable a range of functionalities such as localized delivery, sustained release, and responsiveness. In the context of cell therapies, biomaterials can protect encapsulated cells from immune attack while allowing for nutrient and oxygen exchange. While this approach holds greats potential, the immune response to biomaterials remains a major challenge to the field. Upon implantation of a material, the immune system will initiate the foreign body response, a cascade of inflammatory activity resulting in material fibrosis. For encapsulated cell therapies, biomaterial fibrosis can result in diminished cell functionality or even cell death. To address this challenge, it is critical to design biomaterials which can modulate the host immune response to mitigate fibrosis. In this thesis, we characterize the effect of biomaterial properties on immune responses after implantation. First, we describe how physical properties of alginate capsules can affect the success of encapsulated cell therapy. We find that capsules with lower permeability to IgG and higher strength enable longer encapsulated islet cures in diabetic mice. Furthermore, we show that differences in islet cure lengths were largely dependent on differential capsule immune responses. Next, we describe the effects of E9, an anti-fibrotic biomaterial coating, on macrophage behavior. We find that E9 downregulates CD86 surface expression when immobilized on a biomaterial surface. In addition, E9 downregulates the secretion of several cytokines including MCP-1 and VEGF and upregulates the secretion of IL-1[beta] from macrophages. Next, we describe our work identifying the functional protein targets of E9 to gain further insight into its mechanism of action. We find that Macrophage migration inhibitory factor and Thioredoxin bind E9 and may have roles in its anti-fibrotic activity. Through this work, we identify macrophage proteins and signaling pathways involved in the mechanism of action of E9, leading to an improved understanding of the foreign body response. Overall, by characterizing the effect of material properties on immune responses, we enable rational design of next-generation immunomodulatory biomaterials.

Download or read book Biomaterials in Regenerative Medicine and the Immune System written by Laura Santambrogio and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses. Dr. Santambrogio is Professor of Pathology, Microbiology and Immunology and Orthopedic Surgery at the Albert Einstein College of Medicine. She received her M.D. from the University of Perugia and her Ph.D. from the University of Padua in Italy. She received her postdoctoral training at NYU and Harvard Medical School. One of the focuses of the research in her laboratory is the understanding of the immune responses to implanted biomaterials. .

Download or read book Handbook of Biomaterials Biocompatibility written by Masoud Mozafari and published by Woodhead Publishing. This book was released on 2020-06-17 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

Download or read book Biomaterials Associated Infection written by Fintan Moriarty and published by Springer Science & Business Media. This book was released on 2012-09-29 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

Download or read book Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy written by Anubhab Mukherjee and published by Springer Nature. This book was released on 2022-05-31 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Download or read book Biomaterials for Organ and Tissue Regeneration written by Nihal Vrana and published by Woodhead Publishing. This book was released on 2020-03-20 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Download or read book Regenerative Medicine Applications in Organ Transplantation written by Giuseppe Orlando and published by Academic Press. This book was released on 2013-10-11 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions