Download or read book The Genetic Landscape of Diabetes written by Laura Dean and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunologic and Genetic Factors in Type 1 Diabetes Mellitus written by Ahmad Massoud and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Pathology of Type 1 Diabetes Mellitus written by Matthias G. Von Herrath and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.
Download or read book Type 1 Diabetes written by George S. Eisenbarth and published by Springer Science & Business Media. This book was released on 2004-11-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the field of immunology, type 1 diabetes has become one of the major areas of investigation with studies that span from characterization of key molecules to trials for the prevention of the disease. Type 1 Diabetes : Molecular, Cellular and Clinical Immunology communicates both the background and the most recent understanding of this disorder, which will almost certainly be central to elucidating the etiology of autoimmunity, and in particular of organ specific autoimmunity. The book covers immunogenetics, immunopathogenesis, epidemiology, disease prediction and clinical application of current knowledge. Both scientists seeking to understand and prevent type 1 diabetes/autoimmunity as well as physicians caring for families with type 1 diabetes will be interested in this book.
Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Diabetes written by Steinunn Bækkeskov and published by Springer. This book was released on 1990 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Type 1 Diabetes written by David Wagner and published by BoD – Books on Demand. This book was released on 2011-11-25 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.
Download or read book Immunotherapy of Type 1 Diabetes written by Domenico Andreani and published by John Wiley & Sons. This book was released on 1989 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent national, European and international diabetes meetings have seen controversial discussions on the potential benefit and also on ethical aspects of immune intervention in patients with Type 1 diabetes or in persons with a high risk of developing the disease.
Download or read book Type I Diabetes written by George S. Eisenbarth and published by . This book was released on 1996 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type I diabetes is rapidly becoming one of the most studied autoimmune disorders. The existence of two spontaneous animal models, transgenic models which both create or suppress disease, coupled with the clinical importance of the illness with millions affected and thousands killed each year, has led to enormous efforts by an international groups of investigators to understand, treat and prevent type I diabetes. This timely new book presents a synthesis of the molecular and cellular immunology of type I diabetes by basic immunologists and physician investigators at the Barbara Davis Center for Childhood Diabetes. At this center, T cell clones able to produce diabetes were discovered, the first antigen with which they react characterized, combinatorial, biochemical autoantibody screening for diabetes risk was recently published and multiple trials for the prevention of type I diabetes were carried out. This volume discusses the latest research in this rapidly developing field, including diagnostic strategies and therapies being developed to prevent this disease.
Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.
Download or read book The American Diabetes Association JDRF Type 1 Diabetes Sourcebook written by Anne L. Peters and published by American Diabetes Association. This book was released on 2013-03-29 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Diabetes Association/JDRF Type 1 Diabetes Sourcebook serves as both an evidence-based reference work and consensus report outlining the most critical components of care for individuals with type 1 diabetes throughout their lifespan. The volume serves not only as a comprehensive guide for clinicians, but also reviews the evidence supporting these components of care and provides a perspective on the critical areas of research that are needed to improve our understanding of type 1 diabetes diagnosis and treatment. The volume focuses specifically on the needs of patients with type 1 diabetes and provides clear and detailed guidance on the current standards for the optimal treatment of type 1 diabetes from early childhood to later life. To accomplish the book’s editorial goals, Editors-in-Chief, Drs. Anne Peters and Lori Laffel, assembled an editorial steering committee of prominent research physicians, clinicians, and educators to develop the topical coverage. In addition, a Managing Editor was brought on to help the authors write and focus their chapters.
Download or read book Diabetes Epidemiology Genetics Pathogenesis Diagnosis Prevention and Treatment written by Enzo Bonora and published by Springer. This book was released on 2018-10-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, will be of value for all physicians and nurses who care for patients with diabetes.
Download or read book Defining Optimal Immunotherapies for Type 1 Diabetes written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-07-31 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D). Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials. The book integrates information from human and animal studies. The book considers T1D within the broader context of autoimmune disease. The format contains several discussions, which address specific questions and provides guidelines for future strategies and solutions for discovering a cure.
Download or read book Handbook of Diabetes written by Rudy Bilous and published by John Wiley & Sons. This book was released on 2021-04-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: HANDBOOK OF DIABETES The Handbook of Diabetes provides concise and efficient coverage of the diagnosis, epidemiology, and management of diabetes and its complications. Containing hundreds of attractive colour diagrams, illustrations, and clinical photographs, this popular quick-reference guide focuses on the management and measurement of diabetes mellitus with highly visual references. Now in its fifth edition, this market-leading book aligns with the most recent guidelines from the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), Diabetes UK, and the National Institute for Health and Care Excellence (NICE), presenting authoritative clinical coverage of diabetes in an accessible format with rich pedagogical features. Five new chapters provide detailed coverage of liver disease, diabetes education, bariatric surgery, diabetes and cancer, and the use of incretin-based therapies and SGLT2 Inhibitors in the management of Type II diabetes Updated and expanded topics include the relation between hypoglycaemia and dementia, anxiety and depression, the NICE Quality and Outcomes Framework (QOF), and the impacts of diabetes to self-care, mental health, and decision-making Provides a wealth of pedagogical features such as vignettes and case histories, important learning points, summaries of key clinical trials, and links to further readings Handbook of Diabetes, remains the essential practical companion for all health professionals involved in managing patients with diabetes, and an up-to-date reference for diabetes and endocrinology researchers, scientists, and academics.
Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
Download or read book Viral Infection Immunological Reactions and Genetic Factors Induced Type 1 Diabetes Mellitus in Erbil City written by Najat Jabbar Ahmed and published by . This book was released on 2014 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
