Download or read book Immuno diagnosis of Active Tuberculosis written by Harriet Mayanja-Kizza and published by Frontiers Media SA. This book was released on 2022-11-29 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Significance of antigen and epitope specificity in tuberculosis written by Juraj Ivanyi and published by Frontiers Media SA. This book was released on 2014-12-04 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis.
Download or read book Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection written by Vishwanath Venketaraman and published by Springer. This book was released on 2018-09-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, approximately one third of the world’s population is latently infected with Mycobacterium tuberculosis (M. tb [LTBI]), of whom about 9 million have active tuberculosis (TB). It is estimated that approximately 2 million individuals die each year from active TB. An estimated 14.4% of these individuals have HIV and M. tb co-infection. TB has long been known to be one of the leading causes of death in HIV-infected individuals. Recent evidence now indicates that individuals with type 2 diabetes, the elderly, and chronic smokers are also increasingly susceptible to TB infection, the ability of their immune system to fight off active TB infection having been compromised by their condition. This book therefore aims to provide a detailed review of recent advances in the research that involves characterizing the host’s immune responses against TB infection in conditions such as HIV, diabetes, chronic cigarette smoking and aging, and strategies to restore favorable immune responses against this deadly pathogen.
Download or read book Novel Approaches to Rapid Diagnosis and Treatment Monitoring of Active Tuberculosis Vol II written by Xiao-Yong Fan and published by Frontiers Media SA. This book was released on 2022-11-14 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tuberculosis written by M. Monir Madkour and published by Springer Science & Business Media. This book was released on 2011-04-27 with total page 974 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive textbook on tuberculosis that covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. The main part of the book comprises very detailed and richly illustrated clinical chapters. The copious images are the advantage of this book. Chapters on new methods and treatments and on animal tuberculosis are included. The material is based on a wealth of experience in tuberculosis as seen in endemic countries such as Saudi Arabia that enjoy free access to advanced investigative and therapeutic facilities. This coexistence of endemicity of the disease and state-of-the-art facilities is rare in poor and developing countries or in rich and developed nations. This multidisciplinary volume is ideal for all clinicians, laboratory and research workers, epidemiologists, university teachers and students, health care planners and international organizations involved in world health and infectious disease.
Download or read book Tuberculosis in Clinical Practice written by Onn Min Kon and published by Springer Nature. This book was released on 2021-10-27 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is targeted at ensuring frontline clinical staff including seniors, trainees and specialist nurses can easily reference the optimum investigation and management of potential TB cases. This will mirror the annual London Advanced TB course which aims to equip all of the team delivering care to have a working knowledge of the entire spectrum of the real life aspects of TB management ranging from investigation of active TB to latent screening in pre biologic therapy. It includes an update of MDR TB management and also the approaches needed to ensure the entire medico-social spectrum of TB care is addressed.
Download or read book A Clinician s Guide to Tuberculosis written by Michael D. Iseman and published by Lippincott Raven. This book was released on 2000 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an eminent tuberculosis specialist from a premier medical institution, this volume is a practical clinical reference on tuberculosis. The major focus is on bedside care, including diagnosis, treatment, and patient management. The author clearly and concisely explains which treatments are most effective and addresses the problems of managing HIV-positive patients and drug-resistant strains of tuberculosis. Also included are chapters on basic science, epidemiology, and transmission and a discussion on vaccination and prevention of transmission.
Download or read book Tuberculosis written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by Royal College of Physicians. This book was released on 2006 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biosensing for the 21st Century written by Fred Lisdat and published by Springer. This book was released on 2007-11-20 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Xpert MTB RIF Implementation Manual written by World Health Organization and published by . This book was released on 2015-04-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In December 2010, WHO first recommended the use of the Xpert MTB/RIF assay. The WHO's policy statement was supported by a rapid implementation document, which provided the technical "how-to" and operational considerations for rolling out the use of the assay. An unprecedented uptake of this new technology followed the release of WHO's policy: by the end of March 2014, more than 2,300 GeneXpert instruments and more than 6 million Xpert MTB/RIF cartridges had been procured in the public sector in 104 countries eligible for concessional prices. An Expert Group was convened by WHO in May 2013 to review the current body of evidence on use of Xpert MTB/RIF. The resulting recommendations from the Expert Group are included in the WHO Policy update, which widens the recommended use of Xpert MTB/RIF, including for the diagnosis of paediatric TB and on selected specimens for the diagnosis of extrapulmonary TB, and includes an additional recommendation on the use of Xpert MTB/RIF as the initial diagnostic test in all individuals presumed to have pulmonary TB. The accompanying Xpert MTB/RIF implementation manual has been developed to replace the first edition and takes into consideration the current body of evidence and operational experiences available, in the context of the Policy update.
Download or read book Guidelines on the Management of Latent Tuberculosis Infection written by World Health Organization and published by World Health Organization. This book was released on 2015-01-15 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Latent tuberculosis infection (LTBI), defined as a state of persistent immune response to prior-acquired Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB, affects about one-third of the world's population. Approximately 10% of people with LTBI will develop active TB disease in their lifetime, with the majority developing it within the first five years after initial infection. Currently available treatments have an efficacy ranging from 60% to 90%. Systematic testing and treatment of LTBI in at-risk populations is a critical component of WHO's eight-point framework adapted from the End TB Strategy to target pre-elimination and, ultimately, elimination in low incidence countries. OVERVIEW: Recognizing the importance of expanding the response to LTBI, in 2014 WHO developed Guidelines on the Management of Latent Tuberculosis Infection. The guidelines are primarily targeted at high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100 000 population, because they are most likely to benefit from it due to their current TB epidemiology and resource availability. The overall objective of the guidelines is to provide public health approach guidance on evidence-based practices for testing, treating and managing LTBI in individuals with the highest risk of progression to active disease. Specific objectives include identifying and prioritizing at-risk population groups for targeted intervention of LTBI testing and treatment, including defining an algorithm, and recommending specific treatment options. The guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management based on available resources, epidemiology of TB including intensity of transmission, the health-care delivery system of the country, and other national and local determinants.
Download or read book Systematic Screening for Active Tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2013 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been calls to revisit the experiences of TB screening campaigns that were widely applied in Europe and North America in the mid-20th century, as well as more recent experiences with TB screening in countries with a high burden of the disease, and to assess their possible relevance for TB care and prevention in the 21st century. In response, WHO has developed guidelines on screening for active TB. An extensive review of the evidence has been undertaken. The review suggests that screening, if done in the right way and targeting the right people, may reduce suffering and death, but the review also highlights several reasons to be cautious. As discussed in detail in this book, there is a need to balance potential benefits against the risks and costs of screening; this conclusion is mirrored by the history of TB screening. This publication presents the first comprehensive assessment by WHO of the appropriateness of screening for active TB since the recommendations made in 1974 by the Expert Committee. However, the relative effectiveness and cost effectiveness of screening remain uncertain, a point that is underscored by the systematic reviews presented in this guideline. Evidence suggests that some risk groups should always be screened, whereas the prioritization of other risk groups as well as the choice of screening approach depend on the epidemiology, the health-system context, and the resources available. This book sets out basic principles for prioritizing risk groups and choosing a screening approach; it also emphasizes the importance of assessing the epidemiological situation, adapting approaches to local situations, integrating TB screening into other health-promotion activities, minimizing the risk of harm to individuals, and engaging in continual monitoring and evaluation. It calls for more and better research to assess the impact of screening and to develop and evaluate new screening tests and approaches.
Download or read book Report On General Laws Relative To Combinations Commonly Known As Trusts 1888 89 written by New York (State) General Laws Committee and published by Wentworth Press. This book was released on 2019-03-26 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Global Tuberculosis Report 2017 written by World Health Organization and published by World Health Organization. This book was released on 2017-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO's Global Tuberculosis Report provides a comprehensive and up-to-date assessment of the TB epidemic and of progress in care and prevention at global, regional and country levels. This is done in the context of recommended global TB strategies and associated targets, and broader development goals. For the period 2016-2035, these are WHO's End TB Strategy and the United Nations' (UN) Sustainable Development Goals (SDGs), which share a common aim: to end the global TB epidemic. The main data sources for the report are annual rounds of global TB data collection implemented by WHO's Global TB Program since 1995 and databases maintained by other WHO departments, UNAIDS and the World Bank. In WHO's 2017 round of global TB data collection, 201 countries and territories that account for over 99% of the world's population and TB cases reported data.
Download or read book Global Tuberculosis Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2015 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1. Introduction -- chapter 2. Disease burden and 2015 targets assessment -- chapter 3. TB case notifications and treatment outcomes -- chapter 4. Drug-resistant TB -- chapter 5. Diagnostics and laboratory strengthening -- chapter 6. Addressing the co-epidemics of TB and HIV -- chapter 7. Financing -- chapter 8. Research and development -- Annexes.
Download or read book WHO Consolidated Guidelines on Tuberculosis written by World Health Organization and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Tuberculosis Care and Support informs health care professionals in Member States on how to improve treatment and care for patients with TB. These guidelines group all recommendations on TB care and support in one document and are complemented by an operational handbook. The guidelines are to be used primarily by national TB programmes, or their equivalents in Ministries of Health, stakeholders and technical organizations working on TB care in the public and private sectors and in the community.
Download or read book Global Tuberculosis Report 2018 written by World Health Organization and published by World Health Organization. This book was released on 2018-11-20 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic and of progress in prevention diagnosis and treatment of the disease at global regional and country levels. This is done in the context of recommended global TB strategies and targets endorsed by WHO?s Member States and broader development goals set by the United Nations (UN). The 2018 edition of the global TB report was released on 18 September in the lead up to the first-ever UN High Level Meeting on TB on 26 September 2018.
