Download or read book Immunity to Neisseria gonorrhoeae written by Michael W. Russell and published by Frontiers Media SA. This book was released on 2020-08-27 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathogenesis and Immunity in Experimental Infection with Neisseria Gonorrhoeae written by Lisa M. Chamberlain and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunity Studies on Neisseria Gonorrhoeae written by and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Pathogenesis of Neisseria Gonorrhoeae written by Cynthia N Cornelissen and published by Frontiers E-books. This book was released on with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is dedicated to our current understanding of the molecular pathogenesis of Neisseria gonorrhoeae. Topics in this issue include the following: human infection models for testing gonococcal virulence, animal models that mimic lower female genital tract infection, and an ex vivo system derived from the human female lower genital tract. Vaccine development efforts, and the impact of gonococcal infection on the host's immune response are also described. Also part of this issue are reviews of the molecular aspects of several important virulence factors, including: biofilm formation, neutrophil resistance, innate immune factor resistance, iron acquisition, and type 4 secretion systems.
Download or read book Analysis of Serovar specific Immunity to Neisseria Gonorrhoeae written by Trevor Charles Fudyk and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytokines written by Masoud H. Manjili and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells of the immune system communicate with each other, and respond to abnormal conditions by releasing soluble proteins, named cytokines. Abnormal or dangerous conditions include infection, trauma and injury, neurological disorders, and cancer. The balance between pro- and anti-inflammatory cytokines can comfort or exacerbate the symptoms in these diseases. This book focuses on counter-regulatory and the role of cytokines in different diseases. The goal is to understand contribution of cytokines in the progression of the disease as well as therapeutic potential of cytokines in the treatment of the disease by understanding cytokine counter-regulation.
Download or read book Investigations of a Cell mediated Immune Response to Neisseria Gonorrhoeae in a Mouse Model System written by Rodney Paul Swartz and published by . This book was released on 1979 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mucosal Immunity and Evasion Strategies of Neisseria Gonorrhoeae written by Mónica Imarai and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucosal Immunity and Evasion Strategies of Neisseria gonorrhoeae.
Download or read book Pilin based Vaccine Design for Neisseria Gonorrhoeae written by Johanna Kay Hansen and published by . This book was released on 2007 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Saliva Protection and Transmissible Diseases written by Crispian Scully and published by Academic Press. This book was released on 2017-07-19 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Saliva Protection and Transmissible Diseases provides a review of saliva protection, raising debate on micro-organisms potentially transmissible in saliva, and also considering the evidence on diseases that may be transmitted by kissing. Saliva is a complex body fluid essential to health, especially mastication, swallowing and speech, and hyposalivation can lead to dysfunction and even infection. More serious pathogens, such as herpes viruses and papillomaviruses can be conveyed by kissing, as can potentially lethal micro-organisms present in some saliva, such as meningococci, fungal organisms and Ebola viruses. Stipulates the defensive roles of saliva, an important topic not previously reviewed in-depth in literature Provides awareness that saliva also transmits infectious agents that can produce serious or even lethal diseases Gives understanding that kissing may be an at-risk practice
Download or read book Neisseria Gonorrhoeae written by Myron Christodoulides and published by . This book was released on 2019 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Purification of Surface Antigens of Neisseria Gonorrhoeae Implicated in Immunity written by and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neisseria Gonorrhoeae Infections written by María-Teresa Pérez-Gracia and published by . This book was released on 2021 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gonorrhea is a sexually transmitted infection caused by the obligate human pathogen“Neisseria gonorrhoeae”. This Gram-negative diplococcus is highly infective due to its virulence factors: pili, Por proteins, Opa proteins, Rmp proteins, lipooligosaccharides and IgA protease. Despite existing guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issuesm such as the molecular mechanisms of the disease, diagnostic tests and different treatment strategies used to combat gonorrhea.
Download or read book Neisseria Gonorrhoeae Biofilm Formation and Interaction with the Human Immune System written by Soumya Saha and published by . This book was released on 2017 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigating Complement Regulator Involvement in Innate Immune Evasion by Neisseria Gonorrhoeae written by Donnie Pickel and published by . This book was released on 2021 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial resistant Neisseria gonorrhoeae (Ng) is an urgent threat to public health worldwide. Ng causes gonorrhea, the second most prevalent sexually transmitted bacterial infection. Left untreated, gonorrhea can lead to pelvic inflammatory disease, ectopic pregnancy, sterility, and in men can increase susceptibility to HIV. The current recommended treatment is a dual therapy with two antibiotics azithromycin and ceftriaxone. However, many countries are reporting cases with reduced effectiveness of this treatment method. This has placed a greater urgency on the development of preventative therapeutics. There is currently no commercial vaccine available for Ng infection. The development of preventative treatment strategies has long been impeded by Ng’s ability to evade the immune system, particularly the complement system. Ng is an obligate human pathogen and has evolved numerous mechanisms to interact with host-derived molecules that negatively regulate the activation of the immune system. Previous characterization of these mechanisms has focused on one class of complement inhibitors, fluid-phase inhibitors. To fully understand Ng immune evasion and the host molecules that contribute to it, investigating the role of the other class of complement inhibitors, membrane-associated complement inhibitors (mCIs) is needed. mCIs like CD46, CD55, and CD59 are expressed by human epithelial cells to prevent formation of the membrane attack complex on the surface of human cells. I hypothesized that these proteins may be sequestered by Ng during infection and create localized regions of immune activation allowing Ng to persist. To test this, we used a co-culture serum bactericidal assay (ccSBA) where human epithelial cells were infected with Ng, treated with normal human serum, a vehicle for the components of the complement system, and monitored bacterial viability over time. Using the ccSBA we demonstrated that increasing host expression of mCIs resulted in higher levels of Ng survival, while decreasing mCI expression resulted in lower Ng survival. We then used CRISPR to knock out all three of CD46, CD55, and CD59 simultaneously. Surprisingly, this had the opposite effect of what we expected, resulting in a substantial increase in Ng survival. We observed that the lack of mCIs rendered host cells susceptible to complement and speculated that this could result in the release of host-derived molecules that stimulated an alternative mechanism of Ng immune evasion. We used a strain of Ng deficient in this alternative mechanism and found that the absence of mCI expression resulted in a significant reduction in Ng survival. Finally, we expressed each of CD46, CD55, and CD59 individually and found that all three could support Ng survival alone. In summary, this dissertation shows that mCIs are involved in Ng immune evasion. Further it demonstrates the value of the ccSBA in investigating the role of host-derived molecules in Ng immune evasion.
Download or read book Sexually Transmitted Infections written by Antonio Cristaudo and published by Springer Nature. This book was released on 2020-05-30 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, well-illustrated, and easily accessible book documents the latest research outcomes concerning sexually transmitted infections (STIs) and describes important advances in their prevention, diagnosis and treatment. The changes in the epidemiology and clinical aspects of STIs that have occurred over the past decade are fully explored, with special attention to core groups and patients with immunological disorders. The emerging challenges associated with particular sexually transmitted pathogens, including C. trachomatis, N. gonorrhoeae, HPV, and HIV, are identified and discussed. Readers will find detailed information on modern preventive strategies, new laboratory and diagnostic techniques, and a range of innovative treatments, including vaccines, continuous antiretroviral therapy, and new drugs against hepatitis viruses. Attention is also drawn to new directions in biomedical research that promise clinical benefits for the patients and communities. The combination of a detailed clinical and research approach, with emphasis on new knowledge and innovative aspects, ensures that the book will be of value to a wide readership comprising both clinicians and researchers.
Download or read book Neisseria Gonorrhoeae written by Laurent Brossay and published by . This book was released on 1994 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
