Download or read book Immunity to Neisseria gonorrhoeae written by Michael W. Russell and published by Frontiers Media SA. This book was released on 2020-08-27 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunity Studies on Neisseria Gonorrhoeae written by and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathogenesis and Immunity in Experimental Infection with Neisseria Gonorrhoeae written by Lisa M. Chamberlain and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of Serovar specific Immunity to Neisseria Gonorrhoeae written by Trevor Charles Fudyk and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigating Complement Regulator Involvement in Innate Immune Evasion by Neisseria Gonorrhoeae written by Donnie Pickel and published by . This book was released on 2021 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial resistant Neisseria gonorrhoeae (Ng) is an urgent threat to public health worldwide. Ng causes gonorrhea, the second most prevalent sexually transmitted bacterial infection. Left untreated, gonorrhea can lead to pelvic inflammatory disease, ectopic pregnancy, sterility, and in men can increase susceptibility to HIV. The current recommended treatment is a dual therapy with two antibiotics azithromycin and ceftriaxone. However, many countries are reporting cases with reduced effectiveness of this treatment method. This has placed a greater urgency on the development of preventative therapeutics. There is currently no commercial vaccine available for Ng infection. The development of preventative treatment strategies has long been impeded by Ng’s ability to evade the immune system, particularly the complement system. Ng is an obligate human pathogen and has evolved numerous mechanisms to interact with host-derived molecules that negatively regulate the activation of the immune system. Previous characterization of these mechanisms has focused on one class of complement inhibitors, fluid-phase inhibitors. To fully understand Ng immune evasion and the host molecules that contribute to it, investigating the role of the other class of complement inhibitors, membrane-associated complement inhibitors (mCIs) is needed. mCIs like CD46, CD55, and CD59 are expressed by human epithelial cells to prevent formation of the membrane attack complex on the surface of human cells. I hypothesized that these proteins may be sequestered by Ng during infection and create localized regions of immune activation allowing Ng to persist. To test this, we used a co-culture serum bactericidal assay (ccSBA) where human epithelial cells were infected with Ng, treated with normal human serum, a vehicle for the components of the complement system, and monitored bacterial viability over time. Using the ccSBA we demonstrated that increasing host expression of mCIs resulted in higher levels of Ng survival, while decreasing mCI expression resulted in lower Ng survival. We then used CRISPR to knock out all three of CD46, CD55, and CD59 simultaneously. Surprisingly, this had the opposite effect of what we expected, resulting in a substantial increase in Ng survival. We observed that the lack of mCIs rendered host cells susceptible to complement and speculated that this could result in the release of host-derived molecules that stimulated an alternative mechanism of Ng immune evasion. We used a strain of Ng deficient in this alternative mechanism and found that the absence of mCI expression resulted in a significant reduction in Ng survival. Finally, we expressed each of CD46, CD55, and CD59 individually and found that all three could support Ng survival alone. In summary, this dissertation shows that mCIs are involved in Ng immune evasion. Further it demonstrates the value of the ccSBA in investigating the role of host-derived molecules in Ng immune evasion.
Download or read book Cytokines written by Masoud H. Manjili and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells of the immune system communicate with each other, and respond to abnormal conditions by releasing soluble proteins, named cytokines. Abnormal or dangerous conditions include infection, trauma and injury, neurological disorders, and cancer. The balance between pro- and anti-inflammatory cytokines can comfort or exacerbate the symptoms in these diseases. This book focuses on counter-regulatory and the role of cytokines in different diseases. The goal is to understand contribution of cytokines in the progression of the disease as well as therapeutic potential of cytokines in the treatment of the disease by understanding cytokine counter-regulation.
Download or read book Impact of Neisseria Gonorrhoeae on HIV 1 Replication and Immune Cell Activity in Co infected Peripheral Blood Mononuclear Cells written by Wendy Nicole Dobson-Belaire and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mucosal Immunity and Evasion Strategies of Neisseria Gonorrhoeae written by Mónica Imarai and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucosal Immunity and Evasion Strategies of Neisseria gonorrhoeae.
Download or read book Saliva Protection and Transmissible Diseases written by Crispian Scully and published by Academic Press. This book was released on 2017-07-19 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Saliva Protection and Transmissible Diseases provides a review of saliva protection, raising debate on micro-organisms potentially transmissible in saliva, and also considering the evidence on diseases that may be transmitted by kissing. Saliva is a complex body fluid essential to health, especially mastication, swallowing and speech, and hyposalivation can lead to dysfunction and even infection. More serious pathogens, such as herpes viruses and papillomaviruses can be conveyed by kissing, as can potentially lethal micro-organisms present in some saliva, such as meningococci, fungal organisms and Ebola viruses. Stipulates the defensive roles of saliva, an important topic not previously reviewed in-depth in literature Provides awareness that saliva also transmits infectious agents that can produce serious or even lethal diseases Gives understanding that kissing may be an at-risk practice
Download or read book The Gonococcus written by Richard Bryant Roberts and published by John Wiley & Sons. This book was released on 1977 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Endotoxin in Health and Disease written by Helmut Brade and published by CRC Press. This book was released on 2020-10-28 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Download or read book Neisseria Gonorrhoeae written by Myron Christodoulides and published by . This book was released on 2019 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immune Infertility written by Walter K.H. Krause and published by Springer. This book was released on 2016-11-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
