Download or read book Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation written by Brigitta Omazic and published by . This book was released on 2004 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation in Children written by and published by . This book was released on 2019 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation written by Antoine Toubert and published by Frontiers Media SA. This book was released on 2015-03-12 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution. This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
Download or read book Monitoring of Pathogen Specific T Cell Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation written by Shigeo Fuji and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist Oncologist written by Valerie I. Brown and published by Springer. This book was released on 2017-12-22 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader. Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.
Download or read book Immune Reconstruction After Allogeneic Bone Marrow Transplantation In Pediatric Patients written by Popa Delia Codruta and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEXT: Allogeneic hematopoietic stem cell transplantation (HSCT) has become a well-defined therapeutic strategy for a wide variety of malignant and non-malignant diseases with curative potential. Immune reconstitution post-HSCT is a complex and dynamic process, achieved in stages, depending on the type of transplant, the characteristics of the donor and the recipient, and the occurrence and stage of the graft versus host disease (GvHD).OBJECTIVE: The objective of our study is to identify the correlations between regenerating cell lineage and the time required for complete reconstitution of the immune status depending on the type of allogeneic transplantation.DESIGN: We retrospectively evaluated 16 patients, who have been undergoing allogeneic transplantation between January 2015 and March 2018, and who survived at least 100 days after transplantation in the Pediatric Department, Fundeni Clinical Institute, Bucharest. We analyzed the immune status (B, T and NK cells) by immunophenotyping, using the following markers: Lambda, Kappa, CD56, CD5, CD19, TCRgd/CD16, CD3, CD38, CD20, CD8, CD4, CD45 at well-defined checkpoint intervals (3, 6, 9, 12, and 24 months after the transplant). Absolute values of each subgroup were calculated using the percentage of each subset and absolute count from the leukocytes. RESULTS: In this study, 16 patients have been undergoing allogeneic HSCT transplantation for malignant and non-malignant diseases. There were achieved 5 haploidentical HSCT, 8 HSTC from a matched unrelated donor (MUD), and 4 matched sibling donor (MSD). 5 patients experienced immune recovery during the first 6 months, the NK cells subset has reconstituted in the first 3 months, and the last one to recover was the T cells subset (CD4+). In our study group, the immune reconstitution rate was 20% for haploidentical transplantation, 37.5% for MUD and 25% for MSD. Moreover, delayed immune reconstitution has been associated with the occurrence/reactivation of viral infections (CMV, EBV, BKV, and JCV) with increased frequency in the post-grafting period.CONCLUSIONS: In our center, patients undergoing transplantation from MSD have the fastest immune reconstitution. The immune reconstitution of patients after allogeneic HSCT influences long-term survival by contributing to the management of infectious complications and of GvHD.
Download or read book Assessment of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation written by Meenakshi Singh and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential curative treatment for both congenital and hematological malignancies. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is implicated in successful transplant outcomes such as overall survival and relapse-free survival. The reconstitution of immune cell subsets after HSCT occurs in different phases at different time points encompassing pre-engraftment, engraftment, and post-engraftment. The recovery of innate cellular immunity with the appearance of monocytes, dendritic cells, and natural killer cells in peripheral blood correlates with initiation of cellular engraftment. The cellular adaptive immunity is characterized by both thymic-independent expansion of T cells infused with graft and thymus-dependent expansion of naïve T cells derived from donor stem cells. The humoral immunity consists of B-cell reconstitution, which consists primarily of transitional and naïve subsets with the recovery of memory B cells that occur much later. In this review, we highlight the factors affecting immune reconstitution, the reconstitution of innate and adaptive immunity, techniques to assess immune reconstitution, and ways to enhance it.
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Download or read book EBMT HANDBOOK written by and published by . This book was released on 2025 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Download or read book Immune Reconstitution After Hematopoietic Cell Transplantation written by Jessica Ashley Linderman and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections resulting from poor immunity remain a major complication after hematopoietic cell transplantation (HCT) and this thesis focuses on two main aspects of immune reconstitution post-HCT. First, the role of adoptively transferred mature donor cells in supplementing immunity is addressed. We report that, while animals receiving whole bone marrow transplants have higher levels of immune cells in the blood and no overt manifestations of clinical illness, there is reduced lymph node cellularity after allogeneic transplantation, destruction of lymph node architecture after fully MHC-disparate transplant and poor proliferative responses to a novel antigen. We conclude that the problems associated with subclinical graft-versus-host disease outweigh any benefits of adoptive transfer of mature cells in this setting. The second main area of investigation focuses on the ability of T cells to provide help to donor B cells and induce antibody production to T-dependent antigens after purified hematopoietic stem cell transplant (HSCT). We report that antibody production to a T-dependent antigen is limited to host B cells in fully MHC-disparate chimeras until 12 weeks post-transplant. In contrast, donor and host-derived B cells produce antibody to a T-independent antigen at six weeks in all chimeras studied and to a T-dependent antigen in MHC-matched and haploidentical chimeras where donor and host share an MHC allele. This delayed reconstitution of cells able to provide help to B cells presenting only donor MHC occurs despite the functional development of donor-derived T-Follicular Helper cells, the subset of T cells believed to provide B cell help, at 6 weeks post-HSCT. These data suggest that reconstitution of donor-restricted T cell function may be delayed in fully MHC-disparate hematopoietic chimeras. However, functional donor-restricted responses do eventually develop in the absence of any graft-versus-host disease. We believe that these findings provide important insights into immune reconstitution after MHC-disparate HSCT, and suggest that graft-versus-host disease rather than MHC-disparity may be the major obstacle to immune function after HCT. This work also provides important insights into the function and development of T-Follicular Helper cells.
Download or read book Cells of the Immune System written by Ota Fuchs and published by BoD – Books on Demand. This book was released on 2020-05-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness.
Download or read book Practical Hematopoietic Stem Cell Transplantation written by Andrew J. Cant and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Hematopoietic Stem Cell Transplantation is the only comprehensive yet practical guide to the total care of the transplant patient. It provides a ready source of reference to help health care professionals involved in the management of patients requiring bone marrow and stem cell transplantations – covering many of the infections and complications that may arise. An essential, practical manual for all those working in the field of bone marrow and stem cell transplantation A balanced practical text aimed at the whole multi-disciplinary team Easy to use - practically organized - covering all aspects of pre and post transplant care – including social and psychological aspects Experienced and well respected editorial team Whether you are an established specialist in hematology/oncology, nursing specialist, trainee, or any other member of the hematopoietic stem cell transplant team, this book will answer all your questions about the medical, social and psychological pre and post transplant, patient care.
Download or read book Allogeneic Stem Cell Transplantation written by Mary J. Laughlin and published by Springer Science & Business Media. This book was released on 2002-11-08 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
Download or read book Hematopoietic Stem Cell Transplantation written by Michael R. Bishop and published by Springer Science & Business Media. This book was released on 2009-09-25 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.
Download or read book Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation written by Dominik Schneidawind and published by Frontiers Media SA. This book was released on 2020-05-22 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
