Download or read book Immune Dysfunctions and Abrogation of the Inflammatory Response by Environmental Chemicals written by and published by . This book was released on 1983 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure of immune cells to UDMH induces immune cell dysfunction suggestive of impairment of the immunoregulatory component of the immune system. We found that UDMH does not alter the suppressor cell/helper cell ratio nor does it overtly alter the Ia receptors on immune cells. UDMH does significantly change prostaglandin E2 synthesis. This chemical mediator is known to play a keynote in regulating immune cells.
Download or read book Immune Dysfunctions and Abrogation of the Inflammatory Response by Environmental Chemicals written by Richard G. Olsen and published by . This book was released on 1982 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past year we have further characterized the immunotoxic effects of 1,1-dimethylhydrazine (UDMH). Evidence has been accumulated which indicates that UDMAH interferes with the regulatory arm of the immune system at low dose or concentration levels. Results from earlier experiments which supported this conclusion included: increased Jerne plaque response in UDMH-treated mice; abrogation of concanabalin A-induced suppressor activity following in vivo or in vitro UDMH exposure; and enhancement of lymphocyte blast transformation (LBT) by UDMH-treated lymphocytes. During the past year we have shown that at least one type of regulatory cell which UDMH appears to inhibit is in the adherent cell population of splenocytes. This is demonstrated by the fact that exposure of adherent cells to UDMH enhanced the mixed lymphocyte reaction (MLR). Preliminary experiments now in progress indicate that the UDMH suppresses prostaglandin E (PGE) production by the adherent splenocyte population, which would explain the effects seen in the MLR, as PGE has been shown by others to inhibit various immune responses, including the MLR. Experiments are currently underway which will evaluate the effects of UDMH on PGE synthesis by various subpopulations of lymphocytes and macrophages, as well as on cyclic nucleotide levels and Ia antigen expression (Ia antigen is a product of the immune responder genes). (Author).
Download or read book The Effects of Environmental Chemicals on the Immune System written by S. G. Winslow and published by . This book was released on 1981 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Technical Abstract Bulletin written by and published by . This book was released on 1981 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book AFOSR Technical Report Summaries written by and published by . This book was released on 1984 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicology Research Projects Directory written by and published by . This book was released on 1980-04 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Government reports annual index written by and published by . This book was released on 199? with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Regulation Reporter written by Bureau of National Affairs (Arlington, Va.) and published by . This book was released on 1981 with total page 1448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Safety Science Abstracts Journal written by and published by . This book was released on 1983 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medicine Biology written by and published by . This book was released on 1984-05-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Government Reports Announcements Index written by and published by . This book was released on 1986-11 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pollution Abstracts written by and published by . This book was released on 1983 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indexes material from conference proceedings and hard-to-find documents, in addition to journal articles. Over 1,000 journals are indexed and literature published from 1981 to the present is covered. Topics in pollution and its management are extensively covered from the standpoints of atmosphere, emissions, mathematical models, effects on people and animals, and environmental action. Major areas of coverage include: air pollution, marine pollution, freshwater pollution, sewage and wastewater treatment, waste management, land pollution, toxicology and health, noise, and radiation.
Download or read book Government Reports Annual Index Keyword A L written by and published by . This book was released on 1984 with total page 1528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Unique 3 in 1 Research Development Directory written by and published by . This book was released on 1986 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Record of Proceedings of the Board of Trustees of the Ohio State University written by Ohio State University. Board of Trustees and published by . This book was released on 1983 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Health Planning Health Services Research written by and published by . This book was released on 1987 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Weekly. Summaries of technical reports dealing with health needs, services, facilities, manpower, utilization, education, costs, funding, and activities. Citations arranged under broad topics, e.g., Planning methodology. Entry gives title, author, date, pages, availability or publication information, order number, and abstract.
Download or read book Immunotoxicology and Risk Assessment written by Dennis K. Flaherty and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.
