Download or read book Iminosugars written by Philippe Compain and published by John Wiley & Sons. This book was released on 2007-10-22 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Download or read book Iminosugars as Glycosidase Inhibitors written by Arnold E. Stütz and published by Wiley-VCH. This book was released on 1999-01-21 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iminosugars as Glycosidase Inhibitors Nojirimycin and Beyond Edited by Arnold E. Stutz "Nowadays as a result of these manifold synthetic efforts a large number of inhibitors are available, that can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids. The amount of chemical and biochemical information has meanwhile grown to such an extent that it is almost impossible to keep track of the developments. Therefore it is particularly pleasing that contributions from experts for the individual fields are collected together in one work, thus providing a comprehensive overview. In this way this book gives a representative cross-section of the field. The book will be a generally interesting source of information for chemists and biochemists." (From the foreword by H. Paulsen). A table which lists over 400 glycosidase inhibitors, more than 200 enzymes with 323 citations and over 1500 invaluable sets of data completes the book.

Download or read book Enantioselective Synthesis of Iminosugars and Hexoses from Furfural written by Michael Hans Haukaas and published by . This book was released on 2002 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by Derek Horton and published by Academic Press. This book was released on 2011-12-12 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that bring together industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Download or read book Carbohydrates in Drug Discovery and Development written by Vinod K. Tiwari and published by Elsevier. This book was released on 2020-07-31 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

Download or read book I Studies Toward the Total Synthesis of Iminosugars written by Catherine Marie Smith and published by . This book was released on 2002 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Strategies in Carbohydrate Chemistry written by Vinod Kumar Tiwari and published by Elsevier. This book was released on 2023-11-01 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates

Download or read book Dengue and Zika Control and Antiviral Treatment Strategies written by Rolf Hilgenfeld and published by Springer. This book was released on 2018-05-29 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.

Download or read book Carbohydrates as Drugs written by Peter H. Seeberger and published by Springer. This book was released on 2014-11-14 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 2011-02-09 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. Presents the latest research in the field of drug discovery Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry Available as an online resource via ScienceDirect

Download or read book Carbohydrates 2018 written by Amélia Pilar Rauter and published by MDPI. This book was released on 2020-03-25 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Download or read book Synthesis and Characterization of Glycosides written by Marco Brito-Arias and published by Springer Nature. This book was released on 2022-04-22 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates. Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control. A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.

Download or read book Carbohydrates in Drug Discovery and Development written by Vinod K. Tiwari and published by Elsevier. This book was released on 2020-08-17 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates in Drug Discovery and Development: Synthesis and Application examines important developments in the synthesis, biology and biomedical applications of carbohydrates, along with the therapeutic and pharmacological aspects of carbohydrate chemistry. In addition to the advancement in construction of oligosaccharides, chemists are also making strides in the ability to assemble glycopeptides and glycoproteins. This book covers advanced aspects of carbohydrates, starting with a brief introduction, nomenclature and classification that is followed by a discussion of glyosidic bond formation methodology, recent protocols for the synthesis of O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), carbohydrate modification, and more. Written by a team of international experts actively working on different aspect of synthetic carbohydrate chemistry, this book is an invaluable resource for carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists and biochemists working in industry and academia. Gives a practical, detailed overview on a wide range of carbohydrate systems relevant for drug discovery and development Highlights applications of functionalized carbohydrates and their use as synthons for the construction of various systems Covers recent developments in the synthesis of various glycohybrid molecules

Download or read book Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics written by Laura Cipolla and published by World Scientific. This book was released on 2015-07-23 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Download or read book The Organic Chemistry of Sugars written by Daniel E. Levy and published by CRC Press. This book was released on 2005-09-21 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Download or read book Alpha glucosidase Inhibitors written by Usman Ghani and published by Elsevier. This book was released on 2019-11-19 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of a -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures. Drawing on the author’s expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of a -glucosidase inhibitor chemistry and activity. Identifies and presents promising a-glucosidase inhibitors of natural and synthetic origin that belong to a variety of chemical classes Compiles chemical structures and detailed in vivo and in vitro biological activity data that will help researchers select inhibitors for further work Discusses promising avenues and potential challenges in the development of new a-glucosidase inhibitors based on their activity data

Download or read book Carbohydrate Chemistry written by Amelia Pilar Rauter and published by Royal Society of Chemistry. This book was released on 2017-12-12 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Chemistry demonstrates the interdisciplinary nature of modern carbohydrate research, and benefits any researcher who wishes to learn about the latest developments in the carbohydrate field.