Download or read book Imaging of Fiber Structures in the Posterior Eye written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging the human body is the most important diagnostic tool in healthcare. Therefore, there is an endless need for improvement of imaging techniques. In this thesis, an extension of a medical imaging technique is further developed to provide extra image contrast based on polarization-changing properties of the tissue. This technique, called polarization-sensitive optical coherence tomography (PS-OCT), is an extension of optical coherence tomography (OCT), which is often used in ophthalmology to create high resolution images of the retina of the human eye. Retinal imaging is the main application of PS-OCT chosen for this thesis. Extra image contrast in PS-OCT includes imaging of birefringence, depolarization, and optic axis of the tissue. An in-house built PS-OCT setup is presented and improved. This setup is then used throughout the thesis to create 3D in vivo retinal images of healthy volunteers and patients. Improvements of PS-OCT data analysis are presented and demonstrated in healthy volunteers. A new imaging metric, optic axis uniformity (OAxU), is introduced. OAxU is defined as the length of the spatially averaged optic axis and varies between 0 and 1. Differential Mueller matrix calculations have been implemented and improved to visualize birefringent structures and their optic axes locally. A deep-learning model is developed as a tool to segment the PS-OCT images. Improvement of PS-OCT analysis allows for orientation images of the collagen in the peripapillary sclera, revealing a radially oriented fiber layer preceding a circumferentially orientated fiber layer. Close to the optic nerve head (ONH), the circumferentially oriented layer displaces the radially oriented fiber layer. PS-OCT is used to image patients with high myopia, glaucoma, osteogenesis imperfecta (OI) or wet age-related macular degeneration (wAMD) to compare the visualization of these new findings in ocular fibrillar architecture to healthy volunteers. These diseases are relevant for PS-OCT imaging to detect changes in scleral collagen, damage to the RNFL, or subretinal fibrosis. Multiple parameters are investigated in this study, including birefringence of the sclera and its correlation with axial length, orientations of RNFL in glaucoma patients, dimensions of the circularly oriented sclera (COS) ring, and thickness of the radially oriented sclera (ROS) layer. The ROS is thinner in myopia patients and OI patients. Besides a thinner ROS layer, birefringence of the sclera was lower in OI patients. Fibrosis can be detected and its orientation can be determined in 3D in AMD patients. Fibrosis shows a higher organization than expected and was often observed in large patches of similar orientations which can vary in depth. The applicability of (PS-)OCT goes beyond ophthalmology. In this thesis, it is investigated whether PS-OCT would be valuable in the imaging of airway. Multiple diseased lungs and healthy lungs are imaged ex vivo to investigate differences in alveoli size/presence and ASM thickness. Optic axis orientation images proved very useful to discriminate different birefringent structures, which is not possible in standard OCT imaging. This allowed for automatic ASM segmentation which is relevant for diseases were this layer is thickened such as asthma, fibrotic sarcoidosis (FS), and fibrotic hypersensitivity pneumonitis (fHP).

Download or read book Anterior Posterior Segment OCT Current Technology Future Applications written by Ashok Garg and published by JP Medical Ltd. This book was released on 2014-01-30 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive imaging test that uses light waves to take cross-section pictures of the retina, the light-sensitive tissue lining the back of the eye (geteyesmart.org). Anterior segment OCT covers structures in front of the vitreous humour – iris, cornea, lens and ciliary body. Posterior segment OCT includes the anterior hyaloid membrane and all the structures behind it – vitreous humour, retina, choroid and optic nerve. This book is a comprehensive guide to the use of OCT in anterior and posterior segment surgery. Beginning with an introduction to the technique, the following chapters examine OCT for numerous different procedures including for corneal disorders, glaucoma, diabetic retinopathy, keratoconus and refractive surgery. The accompanying interactive DVD ROM demonstrates intraoperative use of OCT for different surgical procedures. Key points Comprehensive guide to OCT in anterior and posterior segment surgery Covers numerous procedures for different parts of the eye Interactive DVD ROM demonstrates intraoperative use of OCT Includes nearly 270 clinical photographs, diagrams and tables

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Download or read book Optical Coherence Tomography in Glaucoma written by Jullia A. Rosdahl and published by Thieme. This book was released on 2021-09-25 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and user-friendly guide on leveraging OCT for the management of glaucoma Optical coherence tomography (OCT) is a noninvasive diagnostic imaging modality that enables ophthalmologists to visualize different layers of the optic nerve and retinal nerve fiber layer (RNFL) with astounding detail. Today, OCT is an instrumental tool for screening, diagnosing, and tracking the progression of glaucoma in patients. Optical Coherence Tomography in Glaucoma by renowned glaucoma specialist Jullia A. Rosdahl and esteemed contributors is a one-stop, unique resource that summarizes the clinical utility of this imaging technology, from basics to advanced analyses. The book features 14 chapters, starting with introductory chapters that discuss development of OCT and its applications for visualizing the optic nerve and macula. In chapter 5, case studies illustrate OCT imaging of the optic nerve, RNFL, and macula in all stages of glaucoma, from patients at risk to those with mild, moderate, and severe diseases. The next chapters cover the intrinsic relationship between optic nerve structure and function, the use of structure–function maps, and examples of their relationship, followed by a comparison of commonly used devices and a chapter on artifacts. Anterior segment OCT is covered next, followed by chapters covering special considerations in pediatric glaucomas and in patients with high refractive errors. The final chapters cover innovations in OCT on the horizon including OCT angiography, swept-source OCT, and artificial intelligence. Key Highlights Illustrative case examples provide firsthand clinical insights on how OCT can be leveraged to inform glaucoma treatment. In-depth guidance on recognizing and managing artifacts including case examples and key technical steps to help prevent their occurrence. Pearls on the use of OCT for less common patient scenarios such as pediatric glaucomas and high refractive errors. Future OCT directions including angiography, swept-source, and the use of artificial intelligence. This practical resource is essential reading for ophthalmology trainees and ophthalmologists new to using OCT for glaucoma. The pearls, examples, and novel topics in this book will also help experienced clinicians deepen their knowledge and increase confidence using OCT in daily practice.

Download or read book Imaging the Eye from Front to Back with RTVue Fourier domain Optical Coherence Tomography written by David Huang and published by SLACK Incorporated. This book was released on 2010 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fourier-Domain optical coherence tomography (OCT) is the latest technology available to provide high-speed, high-resolution imaging of the cornea, anterior chamber angle, macula, and optic nerve head. It is uniquely suited for ophthalmologists that treat diseases from the front to the back of the eye. Inside Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography, Drs. David Huang, Jay S. Duker, James G. Fujimoto, Bruno Lumbroso, Joel S. Schuman, and Robert N. Weinreb cover up-to-date OCT technology and diagnostic software of the RTVue. It is the first book that covers clinical applications from the front to the back of the eye, as opposed to concentrating either on posterior segment imaging or anterior segment imaging. Inside you'll find: * Explanation of Fourier-Domain OCT technology * Teaching of scan pattern selection * Step-by-step instruction for scan acquisition * Teaching of the interpretations of OCT images and measurements by many case examples * Interpretation of en face images Some chapters covered: * Anterior segment * Cornea * Posterior segment * Retina * Age-related macular degeneration * Diabetic retinopathy * Glaucoma Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography is the must-have book for general ophthalmologists, glaucoma specialists, retina specialists, cornea specialists, and refractive surgeons, as well as biomedical engineers.

Download or read book Imaging Anatomy Brain and Spine written by Anne G. Osborn and published by Elsevier Health Sciences. This book was released on 2020-04-28 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated and superbly organized text/atlas is an excellent point-of-care resource for practitioners at all levels of experience and training. Written by global leaders in the field, Imaging Anatomy: Brain and Spine provides a thorough understanding of the detailed normal anatomy that underlies contemporary imaging. This must-have reference employs a templated, highly formatted design; concise, bulleted text; and state-of- the-art images throughout that identify the clinical entities in each anatomic area. Features more than 2,500 high-resolution images throughout, including 7T MR, fMRI, diffusion tensor MRI, and multidetector row CT images in many planes, combined with over 300 correlative full-color anatomic drawings that show human anatomy in the projections that radiologists use. Covers only the brain and spine, presenting multiplanar normal imaging anatomy in all pertinent modalities for an unsurpassed, comprehensive point-of-care clinical reference. Incorporates recent, stunning advances in imaging such as 7T and functional MR imaging, surface and segmented anatomy, single-photon emission computed tomography (SPECT) scans, dopamine transporter (DAT) scans, and 3D quantitative volumetric scans. Places 7T MR images alongside 3T MR images to highlight the benefits of using 7T MR imaging as it becomes more widely available in the future. Presents essential text in an easy-to-digest, bulleted format, enabling imaging specialists to find quick answers to anatomy questions encountered in daily practice.

Download or read book Ocular Rigidity Biomechanics and Hydrodynamics of the Eye written by Ioannis Pallikaris and published by Springer Nature. This book was released on 2021-05-26 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the concept of ocular rigidity, the biomechanical properties and hydrodynamics of the human eye. The basics of anatomy and physiology are explored and the relevant data for the clinician are emphasized throughout the book. The engineering aspects as well as the clinical interpretation are presented to provide context. Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye summarises recent evidence on ocular rigidity, but also provides a complete presentation of the data so far. The authors have recently worked on ocular rigidity corneal and globe biomechanics and hydrodynamics and the new, up-to-date data on the subject are highlighted in each chapter. The aim is to provide the framework or the understanding of these parameters and to determine their relevance in health and disease. This book will be an essential read for all practicing ophthalmologists looking to gain a more in-depth understanding of this interesting area of research particularly in refractive surgery and glaucoma.

Download or read book Ocular Pathology written by Myron Yanoff and published by . This book was released on 2002 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new, 5th Edition of the premier ocular pathology resource offers the latest information in the field. Over 2095 illustrations *1800 in full color* from the authors' collections represent one of the finest compilations of rare and unusual ocular conditions available. Comprehensive, yet concise, it explores new topics such as complications of corneal surgery, vascular disorders, secondary cataracts, bone-marrow transplant retinopathy, neural retinal detachment, ocular melanotic tumors, and more. Plus, a companion CD-ROM and text/CD-ROM package are available! Explores new topics such as complications of corneal surgery, vascular disorders, secondary cataracts, bone-marrow transplant retinopathy, neural retinal detachment, and ocular melanotic tumors (including diabetes). Offers expanded coverage of entities such as chromosome 17 deletion syndrome, necrobiotic xanthogranuloma, climatic protoglycan stromal keratopathy, unilateral acute idiopathic maculopathy, acute mutifocal retinitis, idiopathic polypoidal choroidal vasculopathy, North Carolina macular dystrophy, familial internal limiting membrane dystrophy, clumped pigmentary retinal dystrophy (clumped pigmentary retinal degeneration), vasoproliferative retinal tumors, Schwartz's syndrome, familial amyloidotic polyneuropathy, familial atypical mole and melanoma (FAM-M) syndrome, and more! Features specific genetic profiles for many existing entities.

Download or read book Digital Optical Measurement Techniques and Applications written by Pramod Rastogi and published by Artech House. This book was released on 2015-05-01 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new resource explains the principles and applications of today’s digital optical measurement techniques. From start to finish, each chapter provides a concise introduction to the concepts and principles of digital optical metrology, followed by a detailed presentation of their applications. The development of all these topics, including their numerous methods, principles, and applications, has been illustrated using a large number of easy-to-understand figures. This book aims to not only help the reader identify the appropriate techniques in function of the measurement requirements, but also assess modern digital measurement systems.

Download or read book Ophthalmic Ultrasonography written by Jeffrey S. Hillman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 9th SIDUO Congress, held in Leeds, UK, July 20-23 1982

Download or read book Diagnostic Endoscopy written by Haishan Zeng and published by Taylor & Francis. This book was released on 2013-12-09 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.

Download or read book Advances in Ocular Imaging in Glaucoma written by Rohit Varma and published by Springer Nature. This book was released on 2020-07-24 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serving as a practical guide to the ocular imaging modalities that are currently available to eye care providers for the care of glaucoma patients, this book provides information on advances in ocular imaging and their applications in the diagnosis and management of glaucoma. Each chapter introduces the imaging modality, highlight its strengths and weaknesses for clinical care, and discuss its integration into the clinical examination and decision-making process. The chapters also provide an in-depth description of the interpretation of images from each imaging modality. When appropriate, the chapters will summarize past and ongoing research and propose future research directions and clinical applications. This title will appeal to ophthalmologists and optometrists at all levels, from trainees to experienced clinicians looking to learn new and important information.

Download or read book Optical Coherence Tomography in Glaucoma written by Ahmet Akman and published by Springer. This book was released on 2018-09-17 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the practical aspects of Optical Coherence Tomography (OCT) in glaucoma diagnostics offering important theoretical information along with many original cases. OCT is a non-invasive imaging technique that acquires high-resolution images of the ocular structures. It enables clinicians to detect glaucoma in the early stages and efficiently monitor the disease. Optical Coherence Tomography in Glaucoma features updated information on technical applications of OCT in glaucoma, reviews recently published literature and provides clinical cases based on Cirrus and Spectralis OCT platforms. In addition, newer techniques like event and trend analyses for progression, macular ganglion cell analysis, and OCT angiography are discussed. This book will serve as a reference for ophthalmologists and optometrists worldwide with a special interest in OCT imaging providing essential guidance on the application of OCT in glaucoma.

Download or read book OCT and Imaging in Central Nervous System Diseases written by Andrzej Grzybowski and published by Springer Nature. This book was released on 2020-01-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

Download or read book Diagnostic and Imaging Techniques in Ophthalmology written by Amar Agarwal and published by JP Medical Ltd. This book was released on 2011-03-31 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances made in diagnostic and imaging tech¬niques within the past years have revolutionized the clinical approach to, and the management of many ophthalmic diseases. Wavefront and Optical Coherence Tomography (OCT) have been incorporated as basic tools of refractive surgery, in the assessment of vitreoreti¬nal disorders, optic nerve pathologies, ocular tumors and ocular trauma. This book presents a comprehensive evaluation of current and emerging technologies used for clinical assessment in ophthalmology, as well as an in depth discussion of retinal angiography, both anterior and exterior segments, OCT, VHF ultrasound and other advanced imaging methods and techniques.

Download or read book Biomechanics of the Eye written by Cynthia J. Roberts and published by Kugler Publications. This book was released on 2018-04-20 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all major components of the ocular system, this state-of-the-art text is essential for vision scientists, biomedical engineers, and advanced clinicians with an interest in the role of mechanics in ocular function, disease, therapeutics, and surgery. With every chapter, leading experts strengthen the arguments that biomechanics is an indispensable and rapidly evolving tool for understanding and managing ocular disease.

Download or read book Assessing Ocular Toxicology in Laboratory Animals written by Andrea B Weir and published by Springer Science & Business Media. This book was released on 2012-12-04 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.