Download or read book Imaging Neuroinflammation written by Cornelia Laule and published by Elsevier. This book was released on 2023-04-13 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more. Explains how inflammation in the central nervous system impacts tissue microstructure Presents imaging methods that are useful for assessing neuroinflammation Describes preclinical models of neuroinflammation Reviews the role of neuroinflammation in human injury and disease states
Download or read book Neuroinflammation written by Alireza Minagar and published by Elsevier. This book was released on 2010-12-17 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities
Download or read book Inflammation in the CNS Advancing the Field Using Intravital Imaging written by Saparna Pai and published by Frontiers Media SA. This book was released on 2017-12-20 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they undergo recruitment from the cerebral microvasculature and following their entry into the CNS parenchyma. However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. This Research Topic brings together state of the art reviews examining the use of in vivo imaging in investigating inflammation and leukocyte behaviour in the CNS. Papers in this Research Topic describe how in vivo microscopy has increased our understanding of the actions of immune cells in the inflamed CNS, following various stimuli including autoimmunity, infection and sterile inflammation.
Download or read book Imaging Inflammation written by Francis Man and published by Springer Nature. This book was released on 2023-03-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging Inflammation provides updates on cutting-edge imaging methods being applied to problems in inflammation research. From state-of-the-art research tools to diagnostic tests, and from single-cell to whole-body imaging, this volume offers a comprehensive overview of how imaging experts across a range of disciplines are expanding our understanding of inflammation and immunity.
Download or read book Neuroinflammation and the Visual System written by Gemma Caterina Maria Rossi and published by Frontiers Media SA. This book was released on 2021-11-23 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammatory Diseases of the Brain written by Stefan Hähnel and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.
Download or read book Imaging In Inflammatory Rheumatic Diseases Recent Advances written by Xenofon Baraliakos and published by Frontiers Media SA. This book was released on 2022-02-02 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroinflammation in Vascular Dementia written by Gary Rosenberg and published by Academic Press. This book was released on 2022-09-07 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline. Reviews the clinical aspects and subtypes of dementia Explains molecular pathways involved in brain inflammation Includes the role of CSF and blood in diagnosis Covers established and novel neuroimaging methods Discusses established and developing treatment strategies Identifies future directions, such as machine learning and precision medicine
Download or read book Neuroinflammation written by Paul L. Wood and published by Springer Science & Business Media. This book was released on 2002-12-18 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.
Download or read book The Inflamed Mind written by Edward Bullmore and published by Picador. This book was released on 2018-12-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.
Download or read book Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury written by Arthur Liesz and published by Frontiers Media SA. This book was released on 2015-11-13 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.
Download or read book Biomarkers of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-16 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
Download or read book Demyelinating and Inflammatory Lesions of the Brain and Spine An Issue of Magnetic Resonance Imaging Clinics of North America E Book written by Reza Forghani and published by Elsevier Health Sciences. This book was released on 2024-04-03 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of MRI Clinics, guest editors Drs. Reza Forghani and Ashok Srinivasan bring their considerable expertise to the topic of Demyelinating and Inflammatory Lesions of the Brain and Spine. Top experts in the field provide multiple articles on multiple sclerosis, as well as articles on bacterial, fungal, and viral infections of the brain and spine. Contains 10 relevant, practice-oriented topics including demyelinating disease: NMO spectrum disorders and variants; toxic and drug-related white matter diseases of the brain and spine; bacterial and viral infectious diseases of the brain; bacterial and viral infectious diseases of the spine; multiple sclerosis: clinical update and clinically-oriented radiologic reporting; basic science of neuroinflammation and involvement of the inflammatory response in disorders of the nervous system; and more. Provides in-depth clinical reviews on demyelinating and inflammatory lesions of the brain and spine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Neuroinflammation and Schizophrenia written by Golam M. Khandaker and published by Springer. This book was released on 2020-01-23 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia.
Download or read book Image Fusion in Preclinical Applications written by Claudia Kuntner-Hannes and published by Springer. This book was released on 2018-12-22 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an accessible and comprehensive overview of the state of the art in multimodal, multiparametric preclinical imaging, covering all the modalities used in preclinical research. The role of different combinations of PET, CT, MR, optical, and optoacoustic imaging methods is examined and explained for a range of applications, from research in oncology, neurology, and cardiology to drug development. Examples of animal studies are highlighted in which multimodal imaging has been pivotal in delivering otherwise unobtainable information. Hardware and software image registration methods and animal-specific factors are also discussed. The readily understandable text is enhanced by numerous informative illustrations that help the reader to appreciate the similarities to, but also the differences from, clinical applications. Image Fusion in Preclinical Applications will be of interest to all who wish to learn more about the use of multimodal/multiparametric imaging as a tool for in vivo investigations in preclinical medical and pharmaceutical research.
Download or read book Brain Imaging written by David B. Teplow and published by Academic Press. This book was released on 2019-09-01 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Imaging, Volume 164, the latest release in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to neuroimaging in aging and neurodegenerative disease. Topics covered in this new release include FTD spectrum, Cerebrovascular disease, HIV, Huntington’s Disease, Development of brain PET imaging agents, and Disclosure of imaging biomarker results. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Download or read book Neuroradiology Applications of High Field MR Imaging An Issue of Neuroimaging Clinics E Book written by Winfried A. Willinek and published by Elsevier Health Sciences. This book was released on 2012-05-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information for neuroimaging specialists includes a "Diagnostic Checklist or “Clinical Recommendations along with tables presenting recommended MR sequences and protocols. The primary focus of the issue is 3.0T; one article specifically deals with 7T and higher fields are mentioned sporadically throughout. Topics include: Tumor High-Field MR; Stroke High-Field MR; High-Field MR of Inflammation; Vascular Disorders: MR Angiography of Brain Vessels, MR Angiography of Neck Vessels, and Perfusion Imaging; Plaque Imaging; Neurodegenerative Disease; Epilepsy Imaging; Head and Neck Oncology Applications; Pediatric High-Field Imaging; Spine High-Field Imaging; Ultra High-Field Imaging; Future Perspectives on High-Field MR
