Download or read book Imaging and Multiomic Biomarker Applications written by Yongxia Zhou and published by Nova Medicine & Health. This book was released on 2021-01-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The well-known Alzheimer's Disease Neuroimaging Initiative (ADNI) Center provides the most advanced, comprehensive, multiparametric and up-to-date biomarkers for mild cognitive impairment (MCI) and early Alzheimer's disease (AD) projects, including neuroimaging, clinical assessments, biospecimens and genetic data. Recent developments in imaging techniques, including new molecular tracers for imaging disease burden and systematic multi-modal integration, have emerged to overcome the limitations of each single modality and individual-dependent variability. The MRI-based high-resolution structural and morphological changes in the brain, such as atrophy, and the abnormal activity/connectivity patterns of the hippocampus subfields and default mode network (DMN) modulation, together with the amyloid and tau neuropathological quantification using PET molecular tracers, could be used to predict brain changes and cognitive performance declines in early AD, including transitional MCI. Finally, a generalized and integrative model with multiple biomarkers could be built to target disease progression and symptom prediction as well as to optimize patient management.Multiomics investigates metabolomic, lipidomic, genomic, transcriptomic and proteomic perspectives by presenting an accurate biochemical profile of the organism in health and disease. The Alzheimer's Disease Metabolomics Consortium (ADMC) in partnership with ADNI is creating a comprehensive biochemical database for patients in the ADNI1 cohort, consisting of eight metabolomics datasets. The vast majorities of biospecimen data provide rich biological information to the human brain at normal and dementia status. One of the purposes is to reveal the connections between disease and multiomics such as obesity, hypertension, cholesterol imbalance and inflammation risks that might lead to neurodegenerative disease. Multiomic biomarker developments in the dementia field have provided earlier clues to novel treatments that help correct metabolic dysfunction and delay disease progression. Furthermore, the assembling of multiomics-based biomarkers including metabolites and lipids, cholesterol biosynthesis, purine metabolism, lipoprotein, bile acids, and genetics as well as their relation to the pathological amyloid and tau network could improve disease diagnosis sensitivity and reveal more diverse and complementary molecular pathways to allow for the advancement of early AD diagnosis and therapeutic prevention. In this book, we report on the significant differences of multiple biomarkers from the ADNI database including neuroimaging, clinical assessments and multiomic biospecimen/genetic data in MCI and early probable AD (pAD), and elucidate the interconnections among different metrics at various domains. Classification results with high accuracies (0.95-1) for each early dementia subtype including early MCI (EMCI), late MCI (LMCI) and pAD, and better prediction of clinical symptoms is achieved with these comprehensive biomarkers. Further longitudinal changes of imaging and neuropsychological biomarkers, and inter-correlations with baseline parameters are examined for a better illustration of disease progression association. Additionally, an analysis of the post-traumatic stress disorder biomarkers is performed with high classification accuracy. With illustrative and rigorous data analyses and confirmative results, this book provides readers with a full spectrum of biomarker research for early dementia diagnosis and treatment, and helps convey the technical development and data evaluation perspectives in advanced medical imaging and various disease application fields.
Download or read book Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations written by Ali Samadikuchaksaraei and published by BoD – Books on Demand. This book was released on 2019-09-04 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.
Download or read book Integrative Imaging in Neuroplasticity Wisdom and Neuropsychiatry written by Yongxia Zhou and published by Ethics International Press. This book was released on 2023-11-25 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book demonstrates the beneficial effects in brain circuits involving memory and attention, reward and social values, decision making and coordination, creativity and persistence of the skills and expertise of continuing education and exposure to the Arts; including chess practice, music/counting, college education and watching movies. These activities were reviewed and investigated using full-spectrum, advanced quantitative imaging techniques. The book highlights extensive applications for this research in common diseases, together with cutting-edge and full-spectrum static and dynamic, functional and structural, regional and inter-network, imaging and phenotypic scales. It will capture the interest of researchers in the areas of neurodevelopmental, neuroplasticity and neuropsychiatric imaging and correlation, as well as disease diagnosis and treatment, and could help convey the methodological innovation and neuroscientific applications of important educational, health and arts/science-related topics.
Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Download or read book Multi omic Data Integration written by Paolo Tieri and published by Frontiers Media SA. This book was released on 2015-09-17 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From these considerations, a novel, pressing request arises from the life sciences to design methodologies and approaches that allow for these data to be interpreted as a whole, i.e. as intertwined molecular signatures containing genes, proteins, mRNAs and miRNAs, able to capture inter-layers connections and complexity. Papers discuss data integration approaches and methods of several types and extents, their application in understanding the pathogenesis of specific diseases or in identifying candidate biomarkers to exploit the full benefit of multi-omic datasets and their intrinsic information content. Topics of interest include, but are not limited to: • Methods for the integration of layered data, including, but not limited to, genomics, transcriptomics, glycomics, proteomics, metabolomics; • Application of multi-omic data integration approaches for diagnostic biomarker discovery in any field of the life sciences; • Innovative approaches for the analysis and the visualization of multi-omic datasets; • Methods and applications for systematic measurements from single/undivided samples (comprising genomic, transcriptomic, proteomic, metabolomic measurements, among others); • Multi-scale approaches for integrated dynamic modelling and simulation; • Implementation of applications, computational resources and repositories devoted to data integration including, but not limited to, data warehousing, database federation, semantic integration, service-oriented and/or wiki integration; • Issues related to the definition and implementation of standards, shared identities and semantics, with particular focus on the integration problem. Research papers, reviews and short communications on all topics related to the above issues were welcomed.
Download or read book Multimodality Imaging and Intervention in Oncology written by Emanuele Neri and published by Springer Nature. This book was released on 2024-01-27 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a focused review of multimodality imaging strategies (radiology and molecular imaging) in staging and re-staging the major types of cancer (i.e. thyroid, breast, colon-rectum, lung, prostate, pancreas, liver, head and neck, and hematological cancer), including rare neoplasms. In addition to presenting the possible diagnostic pathways for all oncologic diseases, the book identifies those interventions currently available in clinical practice (these being a branch of interventional radiology), while also examining and detailing molecular radiotherapy strategies. The work has an interdisciplinary appeal and, thanks to its highly informative and cutting-edge coverage, professionals as well as advanced students and residents in radiology, oncology and surgery will find it of particular interest.
Download or read book Mild Cognitive Impairment Influencing Factors and Intervention Effects written by Ying Wang and published by Frontiers Media SA. This book was released on 2024-07-16 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the aging population degree is deepened, cognitive impairment has become a globally recognized public health problem. As an intermediate state from normal cognition (NC) to Alzheimer's disease (AD), mild cognitive impairment (MCI) has a highly variable cognitive trajectory, which contains three outcomes: 1) progression to AD and other types of dementia; 2) Maintaining stability; 3) Reversal to NC. Reversal of cognitive function can be achieved by taking positive and effective measures. Current studies mostly focus on factors affecting MCI to AD. World Health Organization and Alzheimer’s Disease International have also proposed relatively mature guidelines for risk factors. However, there are still some influencing factors that have not yet formed a unified conclusion. In addition, there are fewer studies and no consensus on the influencing factors for MCI to NC. Current forms of intervention for MCI are mainly non-pharmacological interventions, and there is a lack of randomized controlled trials with larger sample sizes and longer intervention periods to confirm the effect of pharmacological and non-pharmacological interventions. The purpose of this study is to explore the factors that influence the transition from MCI to AD or NC in aging adults, and to examine how the influencing factors make the cognitive function of aging adults with MCI deteriorate, improve or even reverse to NC and how are their reversal rates. This includes effective measures proven through pharmacological and non-pharmacological intervention studies and their impact on reversal. Influence factors include but are not limited to demographic factors (age, socioeconomic status, education), lifestyle (smoking, alcohol consumption, physical activity, nutrition, social participation), mental health (depression, loneliness), diseases (hypertension, diabetes, sleep disorders), biological markers (ß-amyloid, tau protein), and pharmacological factors (cholinesterase inhibitor, Aß monoclonal antibodies, drugs to rebalance the gut flora), etc., and submission of research results based on intervention trials is encouraged.
Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Download or read book Application of Bioinformatics in Cancers written by Chad Brenner and published by MDPI. This book was released on 2019-11-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.
Download or read book Molecular Network Study of Pituitary Adenomas written by Xianquan Zhan and published by Frontiers Media SA. This book was released on 2020-03-13 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field
Download or read book Multi omic Data Integration in Oncology written by Chiara Romualdi and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book OMICS written by Debmalya Barh and published by CRC Press. This book was released on 2013-03-26 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of new technologies and acquired knowledge, the number of fields in omics and their applications in diverse areas are rapidly increasing in the postgenomics era. Such emerging fields—including pharmacogenomics, toxicogenomics, regulomics, spliceomics, metagenomics, and environomics—present budding solutions to combat global challenges in biomedicine, agriculture, and the environment. OMICS: Applications in Biomedical, Agricultural, and Environmental Sciences provides valuable insights into the applications of modern omics technologies to real-world problems in the life sciences. Filling a gap in the literature, it offers a broad, multidisciplinary view of current and emerging applications of omics in a single volume. Written by highly experienced active researchers, each chapter describes a particular area of omics and the associated technologies and applications. Topics covered include: Proteomics, epigenomics, and pharmacogenomics Toxicogenomics and the assessment of environmental pollutants Applications of plant metabolomics Nutrigenomics and its therapeutic applications Microalgal omics and omics approaches in biofuel production Next-generation sequencing and omics technology for transgenic plant analysis Omics approaches in crop improvement Engineering dark-operative chlorophyll synthesis Computational regulomics Omics techniques for the analysis of RNA splicing New fields, including metagenomics, glycomics, and miRNA Breast cancer biomarkers for early detection Environomics strategies for environmental sustainability This timely book explores a wide range of omics application areas in the biomedical, agricultural, and environmental sciences. Throughout, it highlights working solutions as well as open problems and future challenges. Demonstrating the diversity of omics, it introduces readers to state-of-the-art developments and trends in omics-driven research.
Download or read book Radiomics and Radiogenomics written by Ruijiang Li and published by CRC Press. This book was released on 2019-07-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation
Download or read book Artificial Intelligence in Oncology Drug Discovery and Development written by John W. Cassidy and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Perfusion MRI written by Peter B. Barker and published by Cambridge University Press. This book was released on 2013-05-16 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise and comprehensive review uniquely contains all the information required to perform and interpret clinical MR perfusion imaging.
Download or read book Neurovascular Surgery written by Robert F. Spetzler and published by Thieme. This book was released on 2015-04-15 with total page 2918 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex, highly technological field of neurovascular surgery is quickly expanding, encompassing traditional surgical approaches, as well as endovascular and neurointerventional techniques. The last decade has seen increased cross-specialty interest in utilizing minimally invasive techniques to help prevent and treat cerebrovascular disease. Concurrently, there has been important research analyzing the efficacy of surgical methods versus endovascular approaches and the clip versus coil discussion is covered herein. Written by 21st Century pioneers in the field, this second, cutting-edge edition offers the latest science throughout 1,400 pages and a remarkable video library covering anatomy, diagnosis, epidemiology, history, treatment indications, technical nuances, outcomes, and complications. Internationally renowned experts from across the globe share clinical pearls and best practices,from the research lab to the ER to the OR. Medical, surgical, endovascular, cerebral revascularization, bypass surgery, radiation therapy, and other procedures are covered in depth. Evidence-based and transdisciplinary, the second edition covers the full spectrum of neurovascular pathologies,preoperatively and postoperatively,including: Ischemic Stroke and Vascular Insufficiency Cerebral and Spinal Aneurysms Cerebral and Spinal Arteriovenous Fistulae and Malformations Vascular Tumors Carotid Artery Disease Moya-Moya Disease Moya-Moya Disease Revascularization techniques Organized into 11 primary sections, 99 richly illustrated chapters, and more than 140 videos, this volume is an invaluable, one-stop reference tool. It is a must-have for general, vascular and endovascular neurosurgeons; interventional radiologists; neurologists; critical care practitioners; and neuro-rehabilitation specialists.
