Download or read book Identifying Novel Molecular Biomarkers and Therapeutic Targets for Prostate Cancer written by Tanushree Shenoy and published by . This book was released on 2017 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most common malignancy in males, and the third leading cause of male cancer-related death in the Western world. Although most prostate cancers are diagnosed at an early and treatable stages, predicting the outcome of prostate cancer progression and treatment has proven to be challenging because of the heterogeneous nature of the disease. Recent cancer genome studies have identified novel alterations as well as the potential actionable targets. Among these novel alterations is chromodomain helicase DNA-binding protein 1 (CHD1). CHD1 deletion occurs in as many as 20% of prostate cancers and may be associated with genomic instability. To validate the function of CHD1 in prostate cancer in vivo, we created the Pb-Cre+;Chd1L/L mouse model, whereby Chd1 is deleted in mouse prostate epithelial cells, and engineered CHD1-deleted prostate cancer cell lines. We found that while Chd1 deletion alone does not induce prostate cancer in vivo, it confers DNA damage sensitivity and homologous recombination impairment, making CHD1-deficient cells sensitive to PARP inhibitors and Platinum-based drugs. A metastatic castrate-resistant prostate cancer patient whose tumors had CHD1 deletion was responsive to carboplatin, suggesting that CHD1 status may be a biomarker for PARP inhibitor and platinum treatment responsiveness.

Download or read book Identification of Therapeutic Targets and Novel Biomarkers in Prostate Cancer written by Shashwat Sharad and published by Frontiers Media SA. This book was released on 2023-02-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Therapy Resistance in Prostate Cancer written by Hisham Bahmad and published by Elsevier. This book was released on 2023-10-24 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies. Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistance Creates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistance Helps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistance Provides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance

Download or read book Circulating Biomarkers In Prostate Cancer written by Yafeng Ma and published by Frontiers Media SA. This book was released on 2024-02-27 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the era of precision oncology, liquid biopsy techniques, specifically the use of circulating tumor cells (CTCs), cell free circulating tumor DNA (ctDNA) and extracellular vesicles particularly exosomes, represent a paradigm shift in the conventional use of tissue based biomarkers. Compared to tissue biopsy, liquid biopsy is cost-effective, readily accessible and less invasive, minimizing the bias of sampling and offering the opportunity for serial monitoring. Circulating biomarkers detected in liquid biopsy (blood and urine, etc.) are helping in understanding cancer genomic landscape and evolution, thus have been largely studied in term of cancer screening, risk stratification and early detection of minimal residual disease. Castration-resistant prostate cancers (CRPCs) are the late stage of prostate cancers. With significant progress towards the treatment of CRPCs, for example, androgen receptor-signalling (ARS) targeted therapy and immunotherapy, there is an urgent need to identify novel biomarkers to improve the survival rate and prognosis of CRPCs. The study of such biomarkers associated signal pathways and immune status has become a major focus in research to help understanding the responses to drug resistance and ineffective treatments. The discovery of these biomarkers in selecting potentially responsive patients will improve outcomes, and reduce treatment costs and, most importantly, significantly improve patient’s quality of life.

Download or read book Gene Expression Profiles and Biomarker Identification for KMT5A Identifies Novel Potential Therapeutic Targets in Prostate Cancer written by Zainab Adnan Hatem Alebady and published by . This book was released on 2017 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Characterization of Three Novel Candidate Biomarkers and Therapeutic Targets for Prostate Cancer written by Yu Zhang and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Molecular Biology of Prostate Cancer written by Heide Schatten and published by . This book was released on 2018 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature"--Publisher's description.

Download or read book The Identification of Novel Therapeutic Targets for Prostate Cancer written by Kelly Anne Landers and published by . This book was released on 2006 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment, the mortality rate remains high. To improve survival, early detection and treatment strategies tailored to pre-invasive prostate cancer are required. We propose to catalogue genetic alterations associated with the developmental stages of disease for use as diagnostic tools and to identify the critical genes that drive the transformation of premalignant lesions to tumors for use as - molecular targets for novel treatment design. The combination of laser capture microdissection (isolation of specific cell types from hundreds of specimens) and SMAL DNA fingerprinting technology (high-through put analysis of genomic targets using minute quantities of DNA yielded from the microdissected cells) will facilitate systematic comparison of samples in various stages of disease development. By the end of this work, we will have identified a set of genetic loci (and genes) by virtue of their frequency of alteration in premalignant lesions and subsequently in low-grade tumors.

Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pharmacological Reactivation of Epigenetically Regulated Genes for Identification of Therapeutic Targets and Putative Biomarkers in Prostate Cancer written by and published by . This book was released on 2015 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Evaluation of Molecular Biomarkers in Urine for the Detection of Prostate Cancer written by Tamara Sequeiros Fontán and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Metastasis driving Genes as Potential Therapeutic Targets Biomarkers for Metastatic Prostate Cancer written by Yan Ting Chiang and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical and Molecular Characterisation of Prognostic Markers and Therapeutic Targets in Prostate Cancer written by Chee Wee Ong and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identifying Mechanisms of Initiation and Maintenance of Neuroendocrine Prostate Cancer written by Alexandra N. Corella and published by . This book was released on 2020 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small cell or neuroendocrine prostate cancer (SCNPC) is a rare but aggressive subtype of prostate cancer with no FDA-approved targeted therapies. SCNPC is an androgen-receptor independent subtype that often emerges as foci within conventional androgen-receptor dependent prostate cancers (ARPCs) that have undergone androgen-deprivation therapy (ADT). SCNPC and ARPC have highly similar mutational landscapes (including fusions in AR-regulated genes) but display distinct transcriptional programs. Investigations into the molecular mechanisms that are responsible for the development and maintenance of the neuroendocrine phenotype in prostate cancer have been hindered due to the scarcity of tumors and a lack of model systems with which to study the subtype. Small cell or neuroendocrine tumors (SCNTs) arise in many organ sites throughout the body and have similar expression patterns of marker genes used to identify and diagnose this class of tumors, including chromogranins and synaptophysins. In the following thesis, I conducted a transcriptome-wide comparison of SCNTs from different organ sites in order to identify related features. I found similar expression in thousands of genes among SCNTs, including transcription factors that may orchestrate the development of neuroendocrine gene expression programs and their downstream effectors, some of which may present as attractive therapeutic targets. I next evaluated the therapeutic efficacy of inhibiting two such targets using in vitro and in vivo models of SCNPC. Finally, I examined the role of the highly expressed SCNT-associated transcription factor, Insulinoma associated 1 (INSM1), in the development of the neuroendocrine phenotype in prostate cancer. Together this work provides novel insight into the molecular mechanisms that promote the initiation and maintenance of SCNPC.

Download or read book Molecular Biology of Cancer Translation to the Clinic written by and published by Academic Press. This book was released on 2010-12-16 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology over the last several decades are being steadily applied to our understanding of the molecular biology of cancer, and these advances in knowledge are being translated into the clinical practice of oncology. This volume explores some of the most exciting recent advances in basic research on the molecular biology of cancer and how this knowledge is leading to advances in the diagnosis, treatment, and prevention of cancer. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Download or read book The Great Prostate Hoax written by Richard J. Ablin and published by Macmillan. This book was released on 2014-03-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals how fear-based and inaccurate testing is resulting in unnecessary high-risk surgeries, arguing that the PSA test was never intended for prostate cancer screening.