Download or read book Identifying Novel Biomarkers in Bladder Cancer 2nd edition written by Thornsten Ecke and published by Frontiers Media SA. This book was released on 2023-07-18 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bladder cancer is one of the most common urological diseases with a high mortality rate and poor prognosis. It is currently ranked as the 10th most common malignancy worldwide. The majority of bladder cancer patients have been found to be diagnosed with non-muscle invasive bladder cancer (NMIBC) and the remaining, are diagnosed with muscle-invasive bladder cancer (MIBC). Although there have been advances in the treatment and therapies provided for bladder cancer patients, the survival rate remains low, primarily due to recurrence and metastasis of the disease following treatment. Surgical treatment is currently the most common form including radical cystectomy which is the standard form of treatment combined with neoadjuvant chemotherapy. However, the 5-year overall survival rate is 50%. Therefore, further studies are required to understand the molecular mechanisms involved in the progression of bladder cancer and identify novel biomarkers to act as a diagnostic tool for patients. There have been many studies involving the detection of biomarkers in bladder cancer in addition to monitoring disease recurrence to understand the impact and predict potential outcomes. A variety of urine biomarkers have been developed to detect bladder cancer and prognostic risk stratification including mutational DNA and the levels of RNA expression. Circulating tumor cells have also been identified as a potential biomarker for bladder cancer patients. However, there are significant challenges as bladder cancer has demonstrated high levels of cellular and molecular heterogeneity and some markers do not have sufficient sensitivity for accurate detection. Therefore, further studies are required to continue to identify new novel biomarkers for bladder cancer. The aim of this Research Topic is to discuss novel biomarkers in bladder cancer and how it impacts the disease progression and the survival rate for bladder cancer patients.
Download or read book The Development of Pre clinical Models to Study and Identify Novel Biomarkers in Muscle Invasive Bladder Cancer written by James William Robert Douglas and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Current and Novel Biomarkers of Bladder Cancer written by Elizabeth Fowler and published by . This book was released on 2012 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Diagnostic Approach to Bladder Cancer written by Marc A. Bjurlin and published by Springer Nature. This book was released on 2021-09-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This succinct yet comprehensive book describes current and emerging concepts in risk stratification, detection, and staging of bladder cancer. Divided into two distinct sections, the first section focuses on contemporary and novel imaging modalities in bladder cancer staging. The second section illuminates advanced optical techniques and tumor markers for bladder cancer detection. The volume also addresses such topics as novel immuno-positron emission tomography radiotracers, imaging modalities for monitoring of tumor response, and non-invasive urine biomarkers such as current and emerging molecular markers for bladder cancer screening, early diagnosis, and surveillance. Comprehensive Diagnostic Approach to Bladder Cancer: Molecular Imaging and Biomarkers is written by experts in the field and provides a valuable resource for urologists, oncologists, urologic oncologists, radiation oncologists, allied health professionals, residents, and fellows who treat and manage bladder cancer.
Download or read book MicroRNAs Novel Biomarkers and Therapeutic Targets for Human Cancers written by Takahiro Ochiya and published by MDPI. This book was released on 2018-10-16 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM
Download or read book Identifying novel biomarkers in bladder cancer written by Thorsten Ecke and published by Frontiers Media SA. This book was released on 2023-04-27 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diagnostic Prognostic and Predictive Biological Markers in Bladder Cancer Illumination of a Vision 2 0 written by Thorsten Ecke and published by MDPI. This book was released on 2021-02-17 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: After our successful first Special Issue about bladder cancer, we proceeded with the second issue. Again, many international scientists submitted their newest research results in that extremely interesting field and followed our call for submissions. It is not only the collection and combination of old and new markers that could develop new possibilities, but also the focus on different classifications and sub-classifications that will unveil new ways in diagnostic and therapeutic approaches. It seems that the two established diagnostic tools will still play an important role, but new markers and diagnostics tools will present more detailed and more differentiated possibilities in the treatment of urinary bladder cancer. This second Special Issue is full of scientific results that could provide new ways to help patients with instruments for early diagnostics and with predictive and prognostic markers on their way to finding new and personalized strategies for therapy. The editors thank all of the submitting authors for their efforts and time spent on each manuscript. We hope that this Special Issue will prove useful to research work in bladder cancer in the future. We hope that many talented researchers will use multiple forms of art to improve their professional successes and to ameliorate diagnostics and therapy in bladder cancer.
Download or read book Prostate Cancer and the Search for Novel Biomarkers written by Taha Alexander Haj-Ahmad and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Novel Tumor Vasculature Specific Markers as Biomarkers and Therapeutic Targets of Bladder Cancer written by Filip Roudnicky and published by . This book was released on 2014 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proteomicanalysis of Urinary Bladder Cancer written by and published by . This book was released on 2013 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Evaluation of Biomarkers for the Detection of Bladder Cancer written by Hafsa Abbas and published by . This book was released on 2014 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Biomarkers in Bladder Cancer written by Anne Sofie Brems-Eskildsen and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Volatile Organic Compounds written by Emmanual Uche Johnson and published by . This book was released on 2014 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Volatile Organic Compounds written by Emmanual Uche Johnson and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epigenomic Regulation and 3D Genome Structure in Muscle Invasive Bladder Cancers written by Sriranga Iyyanki and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular alterations in the form of gene mutations, gene duplications or deletions, gene expressions, and epigenetic DNA methylation of cis-regulatory promoters have been used to describe clinical features of bladder cancers. This had led to a new paradigm of developing and deploying precision medicine treatment strategies with assisted molecular biomarkers. Specifically, aggressive muscle-invasive bladder cancers have been shown to be characterized by their distinct expression of luminal and basal genes that are associated with key clinical features such as disease progression and overall survival. Transcription factors such as FOXA1, GATA3, and PPAR[gamma] have been shown to be essential for luminal subtype-specific gene regulation and subtype switching, while TP63 and STAT3 are critical for regulation of basal subtype-specific genes. Despite these advances, the underlying epigenetic mechanisms for subtype-specific regulation in bladder cancers remains unknown. This dissertation used a genome-wide and multi-Omics approach to determine the transcriptome, epigenetic promoter and enhancer landscapes and 3D genome structures to describe bladder cancer subtypes and further identifying novel epigenetic mechanisms for the subtype regulation. The first study constructed a multi-Omics resource for studying the bladder cancer epigenome. Integrative analysis of transcriptome and epigenome landscapes of bladder cancer subtypes showed that luminal and basal bladder cancers show coordinated regulation of gene expression with promoter/enhancer histone marks. Open chromatin sites located within the regulatory regions show that the TF repertoire may drive subtype-specific promoters and enhancers in bladder cancers. We also showed that the subtype-specific epigenomic and transcriptome profiling could be used to perform tumor deconvolution to estimate the subtypes in mixed cell populations. Finally, we show distinct 3D genome regulations in bladder cancer subtypes forming distal looping between enhancers and promoters. In our subsequent study, we demonstrated the utility of our resource by exploring subtype-specific TF regulation mechanisms. First, we showed that luminal promoter and enhancer regulatory regions are bound by their luminal-specific TFs FOXA1 and GATA3. Then, we identified a novel clinically relevant transcription factor, Neuronal PAS Domain Protein 2 (NPAS2), in luminal bladder cancers that regulates other luminal-specific genes (including FOXA1, GATA3, and PPAR[gamma]) and influences cancer cell proliferation and migration. In summary, the studies conducted in this dissertation is a comprehensive multi-Omics resource for epigenome and 3D genome for studying molecular subtypes of bladder cancers. Additionally, we demonstrate the utility of our resource through the identification of novel clinically relevant targets such as the circadian TF NPAS2 for potential use in clinical settings.
Download or read book Diagnostic Prognostic and Predictive Biological Markers in Bladder Cancer Illumination of a Vision written by Thorsten Ecke (Ed.) and published by . This book was released on 2019 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue has been introduced with the aim of offering the possibility to publish new research results from old and new pioneers in the field of bladder cancer basic research. While editing this Special Issue we learned that an enormous enthusiasm is necessary to go on in bladder cancer research. In our eyes, bladder cancer is on one hand a very heterogenous malignancy, which is what makes it so difficult to focus on only one bladder cancer marker in bladder cancer diagnostics and follow-up. On the other hand, it is very important to find prognostic and predictive factors for bladder cancer due to its high incidence and its enormous costs, as one of the most expensive malignancies in the world. Finding and developing new bladder cancer markers is still a very dynamic field. Because there are many of these markers, it is impossible to report all of them. This Special Issue attempts to highlight the role of bladder cancer markers in diagnosis, and the most important biomarkers that have been recently studied and reported. This Special Issue highlights some of the most important markers. Further determination of recurrence and progression markers will contribute to establishing better treatments for individual patients. Molecular staging of urological tumors will allow the selection of cases that will require systemic treatment. It is necessary and important to integrate basic and clinical research under the same objectives.
Download or read book WHO Classification of Tumours of the Urinary System and Male Genital Organs written by International Agency for Research on Cancer and published by . This book was released on 2016-02-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Urinary System and Male Genital Organs is the eighth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. It contains numerous color photographs, MRIs, ultrasound images, CT scans, charts and references.
