Download or read book Identification of Biomechanically Valid Cell Therapeutics for Vocal Fold Scarring written by Rebecca Susan Bartlett and published by . This book was released on 2014 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Candidate cell sources for vocal fold scar treatment include mesenchymal stromal cells from bone marrow (BM-MSC) and adipose tissue (AT-MSC). The mechanosensitivity of MSC can alter highly relevant aspects of their behavior, yet virtually nothing is known about how MSC might respond to the dynamic mechanical environment of the larynx. Our objective was to evaluate MSC as a potential cell source for vocal fold tissue engineering using a mechanically relevant in vitro model (Study 1) and in vivo model (Study 2). In Study 1, a bioreactor capable of reproducing the vocal mechanoenvironment was used to evaluate the genomic similarity between MSC and vocal fold fibroblasts (VFF) following vibratory strain. Posterior probabilities for each of the 53,617 microarray transcripts fitting into specific expression patterns were calculated. VFF shared more Gene Ontology (GO) wound healing terms with BM-MSC than with AT-MSC. For example, vibrated VFF and BM-MSC shared similar capacities for glycosaminoglycan and proteoglycan activity, which could favorably effect collagen remodeling in vocal scar. Analysis of GO terms relating to MSC differentiation toward osteogenic, adipogenic, and chondrogenic lineages revealed that BM-MSC expressed fewer osteogenesis terms in the vibrated and scaffold conditions as compared to the polystyrene condition. This was consistent with our hypothesis that tissue-relevant stress encourages tissue-relevant cell differentiation. Lastly, mechanotransductive mechanisms underlying phonatory biology were preliminarily discussed with regard to microarray data, with integrin and lamellipodia activity distinguishing vibrated from non-vibrated cells. Microarray data was confirmed with real-time PCR. Immunostaining for Ki67 (proliferation) was positive in 15- 23% of cells, and cleaved caspase 3 (apoptosis) was positive in 2-7% of cells, and neither varied with cell type or mechanical condition. In Study 2, mature rabbit vocal scars were treated with four variations of MSC therapy. Nine weeks following injection, vocal folds receiving BM-MSC without a hyaluronic acid hydrogel produced the highest levels of a desirable adipogenesis marker (lipoprotein lipase) and an undesirable osteogenesis marker (osteocalcin). Osteocalcin was expressed 452-fold lower than in bone tissue, suggesting a clinically insignificant vocal fold level. As our field progresses toward clinical trials of cell-based vocal scar therapies, consideration of mechanotransductive and differentiation profiles is prudent.

Download or read book Vocal Fold Injection written by Byung-Joo Lee and published by Springer Nature. This book was released on 2021-09-07 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides step-by-step illustrated descriptions of diverse vocal fold injection techniques, including some not previously described. The aim is to provide laryngologists in general, and especially those who are less experienced, with the detailed understanding and guidance needed in order to achieve optimal outcomes. Highly experienced experts describe approaches via the transoral, transnasal, and transcutaneous routes and offer guidance on indications, injection materials, pre- and postoperative care, and the management of complications. Special considerations that must be borne in mind when employing different vocal fold injection techniques, in different settings, are also carefully explained. In offering comprehensive, up-to-date information on this minimally invasive and cost-effective procedure, Vocal Fold Injection will be an essential aid for practitioners.

Download or read book Multidisciplinary Management of Pediatric Voice and Swallowing Disorders written by J. Scott McMurray and published by Springer Nature. This book was released on 2019-11-16 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive review of the assessment and management of pediatric voice and swallow disorders from the perspectives of both the pediatric laryngologist as well as the speech-language pathologist whose collaboration is critical to effective clinical care. All chapters are written by experts in dual fields and formatted to present a straightforward approach to diagnosing and managing each disorder, including descriptions of relevant operative interventions. Multiple intraoperative photographs and illustrations depicting how to perform each surgical procedure are also included. Multidisciplinary Management of Pediatric Voice and Swallowing Disorders will serve as a useful step-by-step guide and resource not only for otolaryngologists and speech-language pathologists, but all members of the pediatric aerodigestive team and other providers caring for children affected by voice and swallowing disorders.

Download or read book Understanding Voice Problems written by Janina K. Casper and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its 3rd edition, this book emphasizes the physiological perspective of voice disorders & the behavioral & emotional factors that can influence these changes. Coverage includes in-depth explorations of patient-interviewing, history-taking, examination & testing.

Download or read book Stem Cells in Aesthetic Procedures written by Melvin A. Shiffman and published by Springer. This book was released on 2014-07-21 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.

Download or read book Aging Voice written by Kiyoshi Makiyama and published by Springer. This book was released on 2017-04-19 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the aging voice, one of the interesting issues related to aging. Population aging is an issue in most developed countries, where both physicians and specialists are required to improve clinical and scientific practice for elderly adults. In particular, the need for expertise in the diagnosis and treatment of aging voice pathologies is increasing continually. New developments in regenerative medicine have taken care for the aging voice to new level, and the contributors to this book use their wealth of experience in the field of the aging voice to present the latest advances in this field. This book is a unique resource, providing new perspectives for physicians, clinicians and health care workers who are interested in the aging voice.

Download or read book Classification Manual for Voice Disorders I written by Katherine Verdolini and published by Psychology Press. This book was released on 2014-04-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: To date, there are 300 disorders associated with voice, but until now there has never been a published reference manual that classifies these disorders. Borrowing from the successful organization schema of the American Psychiatric Association’s Diagnostic Statistical Manual (DSM), the Classification Manual for Voice Disorders-I provides the framework for classifying voice disorders using the following criteria for each disorder: essential and associated features; vocal impairment; clinical history and demographic profile; course and complications; medical and voice differential diagnosis; and severity criteria. Classification Manual for Voice Disorders-I is a project of ASHA’s Special Interest Division 3, Voice and Voice Disorders (DIV 3), originally directed by contributing authors Moya Andrews, Diane Bless, Daniel Boone, Janina Casper, Leslie Glaze, Mike Karnell, Christy Ludlow, and Joe Stemple. The text was edited over a period of several years by the authoritative group of voice disorders professionals, including Katherine Verdolini, Clark Rosen, and Ryan Branski. This version represents the fields of speech-language pathology, voice science, and otolaryngology. CMVD-I lists most conditions that may negatively affect the ability to produce voice, based on the most current knowledge. These conditions comprise 30 structural pathologies, 25 neurological disorders, 20 aerodigestive conditions, 13 psychological disturbances, 15 systemic diseases, four inflammatory processes, four traumatic conditions, and five miscellaneous voice disorders. CMVD-I is a must-have resource for professionals who specialize in voice disorders, especially speech-language pathologists and otolaryngologists. The handy organization of this reference makes it a convenient and accessible resource for voice coaches and teachers of singing. It will also be invaluable as a textbook in master’s-level communication sciences programs throughout the world. Proceeds received by Division 3 will be used to support the mission of Special Interest Division 3, which provides continuing education and networking opportunities to promote leadership and advocacy for voice issues from professional, clinical, educational, and scientific perspectives.

Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Download or read book Speech and Voice Science Fourth Edition written by Alison Behrman and published by Plural Publishing. This book was released on 2021-06-25 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Speech and Voice Science, Fourth Edition is the only textbook to provide comprehensive and detailed information on both voice source and vocal tract contributions to speech production. In addition, it is the only textbook to address dialectical and nonnative language differences in vowel and consonant production, bias in perception of speaker identity, and prosody (suprasegmental features) in detail. With the new edition, clinical application is integrated throughout the text. Due to its highly readable writing style being user-friendly for all levels of students, instructors report using this book for a wide variety of courses, including undergraduate and graduate courses in acoustic phonetics, speech science, instrumentation, and voice disorders. Heavily revised and updated, this fourth edition offers multiple new resources for instructors and students to enhance classroom learning and active student participation. At the same time, this text provides flexibility to allow instructors to construct a classroom learning experience that best suits their course objectives. Speech and Voice Science now has an accompanying workbook for students by Alison Behrman and Donald Finan! New to the Fourth Edition: * Sixteen new illustrations and nineteen revised illustrations, many now in color * New coverage of topics related to diversity, including: * Dialectical and nonnative language differences in vowel and consonant production and what makes all of us have an “accent” (Chapter 7—Vowels and Chapter 8—Consonants) * How suprasegmental features are shaped by dialect and accent (Chapter 9—Prosody) * Perception of speaker identity, including race/ethnicity, gender, and accent (Chapter 11– Speech Perception) * Increased focus on clinical application throughout each chapter, including three new sections * Updated Chapter 4 (Breathing) includes enhanced discussion of speech breathing and new accompanying illustrations. * Updated Chapter 10 (Theories of Speech Production) now includes the DIVA Model, motor learning theory, and clinical applications * Updated Chapter 11 (Speech Perception) now includes revised Motor Learning theory, Mirror Neurons, and clinical applications *Expanded guide for students on best practices for studying in Chapter 1(Introduction) Key Features: * A two-color interior to provide increased readability * Heavily illustrated, including color figures, to enhance information provided in the text * Forty-nine spectrogram figures provide increased clarity of key acoustic features of vowels and consonants * Fourteen clinical cases throughout the book to help students apply speech science principles to clinical practice Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

Download or read book Vocal Fold Scar written by Jaime Eaglin Moore and published by . This book was released on 2016-05-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vocal fold scar remains one of the most demanding and, in some ways, frustrating challenges of laryngology and voice therapy. Treatments for this complex condition are inconsistent and often produce suboptimal results. Yet, while hopes for full recovery remain slim, surgical methods and improving technologies, along with improved therapy techniques, have combined to yield better and better outcomes; and further advances are on the horizon. In this new book, Moore, Sataloff, and Hawshaw have collaborated with world leaders in laryngology and speech-language pathology to compile the latest information on the pathophysiology of vocal fold scar, treatments, procedures and, importantly, look at the promising directions in research. The authors introduce the various causes and sequelae of scar, examine anatomy and pathophysiology, and take the reader through diagnostic procedures. Thereafter, they review preoperative therapy options and providing practical guidance on surgical methods including medialization, techniques for freeing the epithelium, management of sulcus, grafting, and the use of lasers. The book discusses tissue engineering and newer treatment options, including epidermal growth factor (EGF) and transforming growth factor-beta 1 (TGF- 1). The book summarizes the state of the art in diagnosis and treatment of vocal fold scar and should be valuable for any clinician who cares for the patient with this vexing problem."

Download or read book Laryngopharyngeal and Gastroesophageal Reflux written by Craig H. Zalvan and published by Springer Nature. This book was released on 2020-09-29 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects of diet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided. Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient.

Download or read book Ehlers Danlos Syndrome A Multidisciplinary Approach written by J.W.G. Jacobs and published by IOS Press. This book was released on 2018-08-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generalized hypermobility has been known since ancient times, and a clinical description of Ehlers-Danlos syndrome (EDS) is said to have first been recorded by Hippocrates in 400 BC. Hypermobility syndromes occur frequently, but the wide spectrum of possible symptoms, coupled with a relative lack of awareness and recognition, are the reason that they are frequently not recognized, or remain undiagnosed. This book is an international, multidisciplinary guide to hypermobility syndromes, and EDS in particular. It aims to create better awareness of hypermobility syndromes among health professionals, including medical specialists, and to be a guide to the management of such syndromes for patients and practitioners. It is intended for use in daily clinical practice rather than as a reference book for research or the latest developments, and has been written to be understandable for any healthcare worker or educated patient without compromise to the scientific content. The book is organized as follows: chapters on classifications and genetics are followed by chapters on individual types, organ (system) manifestations and complications, and finally ethics and therapeutic strategies, with an appendix on surgery and the precautions which should attend it. A special effort has been made to take account of the perspective of the patient; two of the editors have EDS. The book will be of interest to patients with hypermobility syndromes and their families, as well as to all those healthcare practitioners who may encounter such syndromes in the course of their work.

Download or read book The Management of Voice Disorders written by M. D. Morrison and published by Springer. This book was released on 2013-11-11 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a tremendous growth of interest in the human voice and its disorders during the past decade. This has led to the development of a variety of 'voice labs' or 'voice clinics' that are able to offer unique interdisciplinary assessment and treatment facilities. To cover aJlthe bases, the voice care team requires input frorn laryngology, speech-language pathology, psychiatry, neurology, voice science, music pedagogy, biomedical engineering and other peripheral fields. Because of the multidisciplinary nature of voice dinics there have been a number of books written that address our subject from different professional perspectives. These tend to be multi-authored works that draw on expertise from around the world, such as alaryngologist frorn New York, a speech pathologist from Toronto, etc. All are coJleagues that share similar interests but never actually share the management problems of the same patients. This book has been planned and written by the members ofa single 'voice clinic'iIt is our hope that it willreflect a singleness of direction and purpose in the way it presents our approach to a complex topic. Because of our regular interactive meetings over problem patients inwhich we debate the meaning of our observations, the evolution of etiological dassification systems, and the rationale for particular therapy approaches, we feel that we have become a team that is greater than the sum of its parts, and that there is value in sharing our cumulative thoughts with others. This is not simply a laryngology text for laryngologists.

Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Injection Laryngoplasty written by Giuseppe Bergamini and published by Springer. This book was released on 2015-10-20 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated book provides step-by-step guidance on the various techniques – microlaryngoscopic, fiberoptic endoscopic and transcutaneous – that can be employed for the purpose of injection laryngoplasty, a surgical procedure in which a foreign material is injected into the vocal fold. The anatomy and function of the region are first explained, with identification of the causes and means of evaluation of glottic and neoglottic insufficiency. Advice is then provided on the choice of material for injection laryngoplasty, including absorbable and long-lasting options, on the basis of careful analysis that takes into account both the recent literature and the authors’ own experiences. Detailed descriptions of the surgical indications and different procedures follow and for ease of reference, clear flow charts on diagnosis and indications are also included. The book concludes with chapters on the use of injection laryngoplasty specifically in the pediatric population and on postoperative care and speech therapy following the procedure. Injection Laryngoplasty will provide valuable assistance to all surgeons wishing to perform this kind of surgery.

Download or read book The Many Faces of Osteoarthritis written by Vincent C. Hascall and published by Birkhäuser. This book was released on 2012-12-06 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoarthritis is the most common joint pathology which primarily affects the older population. The disease is characterized by unique pathological changes in some synovial joints, predominantly affecting the articular cartilage, but also entire joints, including the synovial tissue and subchondral bone. The remarkable growth of research on normal and abnormal biology of tissues in the articulating joint, including the application of novel molecular biological approaches and new imaging techniques, is reflected in this volume. It describes the current state of knowledge and helps to further understand the etiopathology of osteoarthritis, hopefully leading to early detection of the disease and novel treatment modalities. The volume contains contributions and discussions from a select group of investigators, all experts in this field, who met at the conference "The Many Faces of Osteoarthritis", held in June 2001 at Lake Tahoe, to acknowledge Klaus E. Kuettner and his contributions to osteoarthritis...

Download or read book Phoniatrics I written by Antoinette am Zehnhoff-Dinnesen and published by Springer. This book was released on 2019-08-15 with total page 1125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of two volumes that draw on the specialized insights and extensive clinical experience of phoniatric experts in order to offer a basis for the development of concerted European training standards in phoniatrics, with the goal of guaranteeing a high quality of care for European patients in all age groups. The interdisciplinary character of phoniatrics is mirrored in the inclusion of valuable contributions from a range of other medical and non-medical disciplines. This volume focuses on voice disorders and disorders of language and hearing development. In each case a wide range of particular kinds of communication loss are considered. Basic aspects are fully addressed, and guidance provided on diagnostic methods, differential diagnosis, prevention, treatment/rehabilitation, and prognosis. An introductory section also discusses the fundamentals of phoniatrics. The reader will benefit from numerous color photos and tables as well as supplementary electronic material, including audio and video examples. This book is intended for residents and practitioners in phoniatrics and also for ENT physicians, medical students, logopedists, and speech and language pathologists and therapists.