Download or read book Current Trends in Organic Synthesis written by Hitosi Nozaki and published by Elsevier. This book was released on 2016-10-27 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Trends in Organic Synthesis is a collection of papers presented at the Fourth International Conference on Organic Synthesis, held in Tokyo, Japan on August 22-27, 1982. This conference brings together the significant achievements in the diversified frontier fields of organic synthesis. This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination. This book is of value to organic chemists and allied scientists.

Download or read book Current Trends in Organic Synthesis written by Carlo Scolastico and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen a rapid growth in the synthetic processing of both simple and complex molecules, aimed at meeting the needs of society in all aspects of life. Many efforts have been devoted to the development of new biologically active compounds, new materials with innovative properties such as bio-compatibility, new catalysts that allow highly selective transformations, and technologies that facilitate the synthetic pro cesses. This book is a compendium of recent progress in all these aspects of synthetic chemistry. It collects the lectures of the XII International Conference on Organic Synthesis, held in Venice from June 28 to July 2, 1998, in which the present state of art of this discipline has been reported. The topics covered include: combinatorial chemistry, new synthetic methods, stereo selective synthesis, metal-mediated synthesis, and target oriented synthesis. The book collects the contributions, in the mentioned topics, of 43 scientists from 19 different countries. The contributions presented in the Conference as plenary lectures are reported in the first section of the book. Particular attention has been dedicated to combinatorial chemistry, a new and promising methodology for the synthesis of libraries of pharmaco logically interesting compounds in order to allow the automatic pharmacological screening of thousands of compounds. The Conference has dedicated to combinatorial chemistry a mini-symposium in which scientists from academy and companies have described the current trends of this very new technology.

Download or read book Asymmetric Metal Catalyzed 3 2 Cycloadditions of Azomethine Ylides written by Remo Stohler and published by Cuvillier Verlag. This book was released on 2007-03-01 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cycloadditions of azomethine ylides with olefins provide a short, attractive route to pyrrolidine units with the potential to control the relative and absolute configuration by means of a chiral catalyst. Grigg and co-workers have pioneered the use of chiral transition metal complexes to induce enantioselective cycloadditions of this type. However, stoichiometric amounts of metal complexes were employed in this work.39a,41 Paying regard to Griggs investigations it was intended to develop a system which gives asymmetric induction using catalytic amounts of chiral transition metal complexes. A first screening of different transition metal sources showed promising results for Cu(I) and Ag(I) species. The application of their complexes with several members of different ligand classes to the 1,3-dipolar cycloaddition reaction directed the interest towards phosphinooxazoline (PHOX) ligands. The catalysts derived from the two different metals and PHOX ligand 39 induced enantioselectivity in both cases (Scheme 46, Table 28). Subsequent investigations demonstrated that also the use of the analogous Au(I) catalyst led to the formation of enantioenriched pyrrolidines.