Download or read book I Domain Integrins written by Donald Gullberg and published by Springer. This book was released on 2014-07-14 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Download or read book I Domains in Integrins written by Donald Gullberg and published by Springer. This book was released on 2003-07-31 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrins written by and published by Elsevier. This book was released on 2007-08-27 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
Download or read book Collagen binding I Domain Integrins what Do They Do written by Donald E. Gullberg and published by . This book was released on 2002 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrin Ligand Interaction written by Johannes A. Elbe and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrins written by and published by Elsevier. This book was released on 2012-12-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Describes key aspects of integrin structure, function, and biology Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists Investigates the expression and role of integrins during development and in the cytoskeleton Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis
Download or read book Adhesion Molecules Function and Inhibition written by Klaus Ley and published by Springer Science & Business Media. This book was released on 2007-08-16 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Download or read book Domain I Integrins written by Donald E. Gullberg and published by Eurekah.Com Incorporated. This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guidebook to the Extracellular Matrix Anchor and Adhesion Proteins written by Thomas Kreis and published by Sambrook and Tooze Publications. This book was released on 1999 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.
Download or read book Mechanisms of Cooperativity and Allosteric Regulation in Proteins written by Max F. Perutz and published by CUP Archive. This book was released on 1990-05-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Revival Integrins The Biological Problems 1994 written by Yoshikazu Takada and published by CRC Press. This book was released on 2017-11-22 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: * the structure and functions of integrin cytoplasmic domains * the role of b2 integrins in leukocyte adhesion * the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis * the functions of aV integrin family * the role of integrins in signal transduction
Download or read book Cell Extracellular Matrix Interactions in Cancer written by Roy Zent and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Analysis of the Integrin Alpha four Cytoplasmic Domain written by Paul David Kassner and published by . This book was released on 1994 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Force Activation of I Domain Containing and Lacking Integrins on Live Cells written by William Parks and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular adhesion plays a crucial role in the biological function of cells, allowing them to communicate and signal, as well as physically anchor, by enabling them to adhere to either other cells or the extra cellular matrix (ECM). This process is regulated by several factors including intrinsic bond kinetics, internal cellular signaling, environment, force exerted on the bond, and force history of the bond. Concerning the force and force history dependence, the observation of catch bonds in integrin binding has asked as more questions than it has answered. To explore the force and force history dependence this process, each bond was loaded to a peak force before relaxing to a much lower force that was held for the duration of the measurement. Two different integrins were studied, both of which have in previous works exhibited a catch bond. Furthermore, the effects of different metal ion conditions and an allosteric antagonist were also studied to elucidate the conformational effects on force priming of integrin. What was observed was that I domain, or ©3¡2©5℗ư©30́(©2±A domain, possessing integrin, whether tested against its more active or less active binding state, changed very little in terms of off rate once the priming force was applied. However in the I domain, or ©3¡2©5℗ư©30́(©2±A domain, lacking integrin, the observed off rate changed as well. It seems that force priming is capable of causing integrin to bind in a stronger manner regardless of the other conditions used to either activate or inhibit binding. However the way in which the binding is strengthened depends on the receptors structure.
Download or read book Structural Basis of Protein Function written by Yvonne Nymalm and published by . This book was released on 2004 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
