Download or read book Hyperpolarized Noble Gas MRI of Human Lungs in 150G Magnetic Field written by Adelaide Zhang and published by . This book was released on 2000 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hyperpolarized and Inert Gas MRI written by Mitchell S. Albert and published by Academic Press. This book was released on 2016-11-17 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990’s, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer’s disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource. Presents the most comprehensive, relevant, and accurate information on HP gas MRI Co-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplines Serves as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRI Covers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted
Download or read book Hyperpolarized Noble Gas Magnetic Resonance Imaging of the Ex Vivo Rodent Lung written by D. M. L. Lilburn and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hyperpolarized Noble Gas Magnetic Resonance Imaging of the Ex Vivo Rodent Lung written by David M. L. Lilburn and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optimization of Hyperpolarized Noble Gas Magnetic Resonance Imaging written by Lei Zhao and published by . This book was released on 2000 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hyperpolarized Helium 3 Diffusion Magnetic Resonance Imaging in Human Lungs written by Chengbo Wang and published by VDM Publishing. This book was released on 2008 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: COPD and asthma have significant morbidity and mortality. Hyperpolarized (HP) 3He Diffusion MRI has been used to assess lung diseases. The results correlated well with histology, but the diffusion time for previous methods is limited to the order of milliseconds under 1.5 T. New MR methods were developed to measure HP 3He diffusion over the long-time scale (LTS: diffusion time on the order of seconds) in human lungs and were used to investigate COPD and asthma. The basic equations were developed, numerical simulation was performed, and measurements were made in phantoms. Measurements in healthy subjects confirmed that 3He diffusion still strongly depended on the diffusion time in LTS and the ADC decreased significantly. Reproducibility, anisotropy and dependence on parameters were characterized. Experiments in patients with COPD suggested that LTS diffusion was more sensitive to early COPD changes than short-time-scale diffusion. Measurements in patients with severe asthma revealed large regional elevations in LTS ADC maps while the changes in STS were smaller. And there was a good correlation between LTS ADC maps and areas of low-density "air-trapping" seen by CT.
Download or read book Magnetic Resonance Imaging of Hyperpolarised 129Xe Gas in the Human Lungs written by Xiaojun Xu and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Magnetic Resonance Imaging of Lungs at Ultra low Magnetic Field Strength Using Hyperpolarized 1 2 9Xe Gas microform written by Juan Miguel Parra Robles and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MRI of the Lung written by Hans-Ulrich Kauczor and published by Springer. This book was released on 2018-11-28 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions. During the past two decades, significant advances in the technology have enabled MRI to enter and mature in the clinical arena of chest imaging. Standard protocols are now readily available on MR scanners, and MRI is recommended as the first- or second-line imaging modality for a variety of lung diseases, not limited to cystic fibrosis, pulmonary hypertension, and lung cancer. The benefits and added value of MRI originate from its ability to both visualize lung structure and provide information on different aspects of lung function, such as perfusion, respiratory motion, ventilation, and gas exchange. On this basis, novel quantitative surrogates for lung function and therapy control (imaging biomarkers) are generated. The second edition of MRI of the Lung has been fully updated to take account of recent advances. It is written by an internationally balanced team of renowned authors representing all major groups in the field.
Download or read book Diffusion Relaxation and Magnetic Resonance Imaging Studies of Noble Gases written by Ivan Emilov Dimitrov and published by . This book was released on 2000 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hyperpolarized 3He Diffusion Magnetic Resonance Imaging in Human Lungs written by Chengbo Wang and published by . This book was released on 2007 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hyperpolarized Noble Gas Magnetic Resonance Imaging and Dynamic Spectroscopy for Investigation of Rat Models of Lung Inflammation written by Matthew Stephen Fox and published by . This book was released on 2012 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging of the lungs using non-ionizing approaches such as hyperpolarized 3He and 129Xe magnetic resonance imaging (MRI) is a useful tool both for research and clinical applications. This work focused on development of 129Xe MRI techniques to investigate inflammation in rat lungs. A rodent model of inflammation, specifically radiationinduced lung injury (RILI) was developed using a collimated 60Co source. A quantitative MRI technique measuring absolute ventilated lung volume (values obtained from rats using the previously established 3He method and those obtained with 129Xe, the usefulness of 129Xe for future investigations of.
Download or read book Investigation of Lung Structure function Relationships Using Hyperpolarized Noble Gases written by Robert P. Thomen and published by . This book was released on 2016 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is an application of the nuclear magnetic resonance (NMR) phenomenon to non-invasively generate 3D tomographic images. MRI is an emerging modality for the lung, but it suffers from low sensitivity due to inherent low tissue density and short T2*. Hyperpolarization is a process by which the nuclear contribution to NMR signal is greatly enhanced to more than 100,000 times that of samples in thermal equilibrium. The noble gases 3He and 129Xe are most often hyperpolarized by transfer of light angular momentum through the electron of a vaporized alkali metal to the noble gas nucleus (called Spin Exchange Optical Pumping). The enhancement in NMR signal is so great that the gas itself can be imaged via MRI, and because noble gases are chemically inert, they can be safely inhaled by a subject, and the gas distribution within the interior of the lung can be imaged. The mechanics of respiration is an elegant physical process by which air is is brought into the distal airspaces of the lungs for oxygen/carbon dioxide gas exchange with blood. Therefore proper description of lung function is intricately related to its physical structure, and the basic mechanical operation of healthy lungs -- from pressure driven airflow, to alveolar airspace gas kinetics, to gas exchange by blood/gas concentration gradients, to elastic contraction of parenchymal tissue -- is a process decidedly governed by the laws of physics. This dissertation will describe experiments investigating the relationship of lung structure and function using hyperpolarized (HP) noble gas MRI. In particular HP gases will be applied to the study of several pulmonary diseases each of which demonstrates unique structure-function abnormalities: asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Successful implementation of an HP gas acquisition protocol for pulmonary studies is an involved and stratified undertaking which requires a solid theoretical foundation in NMR and hyperpolarization theory, construction of dedicated hardware, development of dedicated software, and appropriate image analysis techniques for all acquired data. The author has been actively involved in each of these and has dedicated specific chapters of this dissertation to their description. First, a brief description of lung structure-function investigations and pulmonary imaging will be given (chapter 1). Brief discussions of basic NMR, MRI, and hyperpolarization theory will be given (chapters 2 and 3) followed by their particular methods of implementation in this work (chapters 4 and 5). Analysis of acquired HP gas images will be discussed (chapter 6), and the investigational procedures and results for each lung disease examined will be detailed (chapter 7). Finally, a quick digression on the strengths and limitations of HP gas MRI will be provided (chapter 8).
Download or read book Functional Imaging of the Lungs Using Magnetic Resonance Imaging of Inert Fluorinated Gases written by Marcus Couch and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize the distribution of the inhaled gas, similar to hyperpolarized (HP) helium-3 (3He) and xenon-129 (129Xe) MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared to HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single breath-hold is possible due to short longitudinal relaxation times. Since inert fluorinated gases do not need to be hyperpolarized prior to their use in MRI, this eliminates the need for an expensive polarizer and expensive isotopes. Inert fluorinated gas MRI of the lungs has been studied extensively in animals since the 1980s, and more recently in healthy volunteers and patients with lung diseases. This thesis focused on the development of static breath-hold inert fluorinated gas MR imaging techniques, as well as the development functional imaging biomarkers in humans and animal models of pulmonary disease. Optimized ultrashort echo time (UTE) 19F MR imaging was performed in healthy volunteers, and images from different gas breathing techniques were quantitatively compared. 19F UTE MR imaging was then quantitatively compared to 19F gradient echo imaging in both healthy volunteers and in a resolution phantom. A preliminary comparison to HP 3He MR imaging is also presented, along with preliminary 19F measurements of the apparent diffusion coefficient (ADC) and iv gravitational gradients of ventilation in healthy volunteers. The potential of inert fluorinated gas MRI in detecting pulmonary diseases was further explored by performing ventilation mapping in animal models of inflammation and fibrosis. Overall, interest in pulmonary 19F MRI of inert fluorinated gases is increasing, and numerous sites around the world are now interested in developing this technique. This work may help to demonstrate that inert fluorinated gas MRI has the potential to be a viable clinical imaging modality that can provide useful information for the diagnosis and management of chronic respiratory diseases.
Download or read book Radio Frequency Coil and Pulse Sequence Design for Hyperpolarised Noble Gas MRI of the Human Lungs and Brain written by Madhwesha Rama Rao and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Pseudo Non Cartesian Pulse Sequence For Hyperpolarized Xenon 129 Gas MRI of Rodent Lungs At Low Magnetic Field Strength written by Krzysztof Wawryzn and published by . This book was released on 2014 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Early diagnosis of radiation-induced lung injury (RILI) following radiation therapy is critical for prevention of permanent lung damage. Pulmonary imaging using magnetic resonance imaging (MRI) of the apparent diffusion coefficient (ADC) of hyperpolarized xenon (129Xe) gas shows promise for early measurement of RILI. Methods: An ultra-short echo time imaging sequence based on a pseudo-Cartesian kspace trajectory, known as Sectoral, is implemented at low magnetic field (0.07 T) for efficient use of the non-renewable magnetization of hyperpolarized 129Xe gas. A pilot study was performed to demonstrate the feasibility of ADC mapping using the Sectoral sequence on healthy and 2-weeks post irradiated rats. Results: A significant (p
Download or read book Radio Frequency Coil and Pulse Sequence Design for Hyperpolarised Noble Gas MRI of the Human Lungs and Brain written by Madhwesha Rama Rao and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
