Download or read book Hypercholesterolemia Hypocholesterolemia Hypertriglyceridemia in Vivo Kinetics written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.
Download or read book Nutrition in the Prevention and Treatment of Cardiovascular Diseases written by Zhendong Liu and published by Frontiers Media SA. This book was released on 2024-07-18 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, which brings about a major public health burden. An increasing body of literature suggests that nutritional factors strongly affect CVD risks and progression. There is consensus among researchers that nutritional deficiency, as well as nutritional excess, both increase the risk of CVDs. In addition, it is increasingly recognized that not only nutrients but also dietary patterns play a role in CVDs. Furthermore, nutritional status and diet quality is also becoming a concern in regard to CVD development and outcomes. However, CVDs are complicated diseases with various causes, which leads to inconsistencies in determining the best nutritional practice. Further research is required to identify effective ways of improving nutritional status in order to prevent, delay or reduce adverse outcomes of CVDs. The goal of this research topic is to highlight the central role of nutrition in both primary and secondary prevention of CVDs. We will focus on the latest evidence from observational and clinical studies, regarding the influence of nutrients, dietary patterns, diet quality, nutrition status on CVDs development and outcomes. We hope to showcase research progress, identify the feasibility and impact of nutritional interventions, and shed light on future directions for research.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1973 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Triglyceride High Density Lipoprotein and Coronary Heart Disease written by Naomi Miller and published by . This book was released on 1992 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This bibliography is organized into sections on background; relationship of high density lipoprotein, triglyceride, and coronary heart disease; genetics and genetic syndromes; secondary causes of high triglyceride and low high density lipoprotein; measurement of high density lipoprotein and triglyceride; evidence from clinical trials; approach to high triglyceride and low high density lipoprotein; and monographs.
Download or read book Current Bibliographies in Medicine written by and published by . This book was released on 1988 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Temperature and Environmental Effects on the Testis written by Adrian W. Zorgniotti and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: It must be considered that there is nothing more difficult to carry out, nor more doubtful of success, nor more dangerous to handle, than to initiate a new order of things. Machiavelli: The Prince (1513) These are the Proceedings of a Conference on Temperature and Environmental Factors and the Testis which took place at New York University School of Medicine, December 8th and 9th, 1989. There is good reason to believe that this was the first of its kind to address, exclusively, the implications of temperature for this highly thermosensitive organ and its precious genetic cargo. The organizers of the Conference hoped to stimulate interest in this area which, paradoxically, has a considerable literature but which has received scant attention and sometimes outright opposition from clinicians expert in male infertility. There have been studies of the relationship of temperature to reproduction starting in the mid-18th Century with observations of the relationship of water temperature to spawning of fish. There is also a vast literature on the deleterious effects of externally applied heat upon spermatogenesis but little study of the possibility that intrinsic heat may be an important etiologic factor in subfertile semen. Today, fertility research has largely ignored this in favor of research in areas which have not produced successes, in terms of live births, comparable to what can be obtained by varicocelectomy (when appropriate) or scrotal hypothermia: viz. 1. Concentration upon the endocrine aspects of testicular function and its relation to spermatogenesis.
Download or read book Neuroreceptor Mechanisms in Brain written by Shozo Kito and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers contained in this volume constitute a state of-the-art survey of the most advanced aspects of neurotransmitter recep tor mechanisms in the brain. lowe thanks for the great success of the symposium to Prof. Richard Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya Tohyama of Osaka University. I express my sincere gratitude to many friends for making this publication possible. I especially thank Dr. Rie Miyoshi, whose devoted efforts as secretary-general were vital to the success of the symposium. Dr. Miyoshi is currently an instructor in the Department of Pharmacology at Tokyo Women's Medical College. I would also like to acknowledge the excellent secretarial work of Misses Ritsuko Sato and Yuko Wakita.
Download or read book Enzymology and Molecular Biology of Carbonyl Metabolism 3 written by David W. Crabb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held at Purdue University in June, 1990. This represents the fifth time that I had the privilege of organizing the scientific program. It was the first time that I actually hosted the meeting. I wish to salute my four previous co-organizers and the thousands of scientists who have hosted other meetings. It is much easier to arrange the scientific program and edit the proceedings. No local organization could occur without the help of ones research group and, in this case, my wife. I sincerely thank Esther and my research group for their advise and help. At this Workshop, similar to the preceeding ones, much new information was presented. It was apparent how molecular biological techniques were influencing the direction of the research on the three families of enzymes discussed. It also was apparent that not all biochemical problems could be solved by using these techniques. Many of the presentations showed how important advances still could be made using more traditional biochemical approaches.
Download or read book The Identification of the CF Cystic Fibrosis Gene written by Lap-Chee Tsui and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of an international workshop held in Sestri Levante (Genoa), Italy, April 9--11, 1990
Download or read book Drugs of Abuse Immunity and Immunodeficiency written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the program of the International Conference on Drugs of Abuse, Immunity and Immunodeficiency held in Clearwater Beach, Florida. It was sponsored by the University of South Florida College of Medicine with the support of the National Institute on Drug Abuse. During the past few decades, drugs of abuse, including marijuana, cocaine, opiates and alcohol, have been studied by biomedical scientists in terms of the systemic effects of the drugs as well as alterations in neurophysiology and the psychology. More recently, the scope of such investigations has been broadened to include alterations within the immune system, and the influence of altered immunity on physiological and psychological consequences of drug abuse. In this regard, participants in the Clearwater Beach conference provided new information concern ing both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiency. Advances have been made in recent years in understanding the nature and mechanisms regulating the immune response and the mechanisms by which drugs may influence immune responses. In particular, the emergence of psychoneuroimmunology as a new discipline has heightened interest in immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving clinical and basic scientists including microbiologists, immu nologists, physiologists, psychiatrists, oncologists and others. The recreational use of the above mentioned drugs by large numbers of individuals has aroused serious concern about the consequences of this activity.
Download or read book Fuel Homeostasis and the Nervous System written by Mladen Vranic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has a dual purpose, to review in depth the control of fuel homeostasis in the brain and the role of the nervous system in the control of fuel deposition in the body. From the methodological point of view the emphasis is on the application of advanced technologies to assess fuel transport and brain metabolism, the role of peptides in the neuroendocrine system and the response of the brain to hypoglycemia. These technologies include positron emmission tomography, nuclear magnetic resonance, immunocytochemistry, molecular biology, autoradiography. To study fuel homeostasis in the body advanced tracer methods that include modelling are set out. From the pathophysiological point of view the emphasis is on abnormalities in stress, brain metabolism in diabetes, eating and degenerative disorders. This book contains contributions from endocrinologists, physiologists, neurologists, psychoneuroendocrinOlogists, biophysicists, biochemists and experts in nutrition. This authorship represents a unique diversity of researchers who, for the first time, cover comprehensively the interaction between the nervous system and fuel homeostasis, both in health and disease. We hope this book will be an important source of information for both researchers and practicing clinicians. Mladen Vranic Suad Efendic Charles Hollenberg v ACKNOWLEDGEMENTS The Symposium from which this volume arose (University of Toronto, June 27-28, 1990) was the first Toronto-Stockholm symposium on Perspectives in Diabetes Research. These Symposia are organized triennially by the Banting and Best Diabetes Centre, University of Toronto and the Department of Endocrinology, Karolinska Institute, Stockholm.
Download or read book Nutritional and Toxicological Consequences of Food Processing written by Mendel Friedman and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of processing methods are used to make foods edible; to pennit storage; to alter texture and flavor; to sterilize and pasteurize food; and to destroy microorganisms and other toxins. These methods include baking, broiling, cooking, freezing, frying, and roasting. Many such efforts have both beneficial and harmful effects. It is a paradox of nature that the processing of foods can improve nutrition, quality, safety, and taste, and yet occasionally lead to the formation of anti-nutritional and toxic compounds. These multifaceted consequences of food processing arise from molecular interactions among nutrients with each other and with other food ingredients. Since beneficial and adverse effects of food processing are of increasing importance to food science, nutrition, and human health, and since many of the compounds formed have been shown to be potent carcinogens and growth inhibitors in animals, I organized a symposium broadly concerned with the nutritional and toxicological consequences of food processing. The symposium was sponsored by the American Institute of Nutrition (AIN) -Federation of American Societies for Experimental Biology (FASEB) for its annual meeting in Washington, D.C., April 1-5, 1990. Invited speakers were asked to develop at least one of the following topics: 1. Nutrient-nonnutrient interactions between amino acids, proteins, carbohydrates, lipids, minerals, vitamins, tannins, fiber, natural toxicants, etc. 2. Effects of radiation. 3. Thermally induced formation of dietary mutagens, antimutagens, carcinogens, anticarcinogens, antioxidants, and growth inhibitors. 4. Effects of pH on nutritional value and safety.
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation III written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.
Download or read book The Cumulative Book Index written by and published by . This book was released on 1991 with total page 2216 pages. Available in PDF, EPUB and Kindle. Book excerpt: A world list of books in the English language.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Metabolism of Apolipoprotein B in Subjects with LDL Subclass Phenotype A and B written by Dorin Lockhart Willey and published by . This book was released on 1993 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Directory of Published Proceedings written by and published by . This book was released on 1992 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
