Download or read book Hydrophilic Matrix Tablets for Oral Controlled Release written by Peter Timmins and published by Springer. This book was released on 2014-10-11 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
Download or read book Hydrophilic Matrix Tablets for Oral Controlled Release written by Peter Timmins and published by Springer. This book was released on 2016-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
Download or read book Oral Controlled Release Formulation Design and Drug Delivery written by Hong Wen and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
Download or read book Controlled Release in Oral Drug Delivery written by Clive G. Wilson and published by Springer Science & Business Media. This book was released on 2011-09-22 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Download or read book Modulation and Assessment of Controlled Released Matrix Tablet of Losartan Potassium written by Amit Khairnar and published by GRIN Verlag. This book was released on 2012-10-16 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wissenschaftliche Studie aus dem Jahr 2012 im Fachbereich Pharmazie, Institute of Pharmaceutical Education Boradi, Sprache: Deutsch, Abstract: Ideally, a drug should arrive rapidly at the site of action (receptor) in the optimum concentration, remain for the desired time, be excluded from other sites, and be rapidly removed when the goal is achieved. Generally, the time course of a dosage form (pharmacokinetics) in man is considered to be controlled by the chemical structure of the drug. Decreasing the rate of absorption and/or changing the dosage form provide a useful adjunct. When it is not feasible or desirable to modify the drug compound on a molecular level, often sought is a product that will require less frequent administration to obtain the required biological activity time profile. It may be desirable to decrease the absorption rate in order to obtain a more acceptable clinical response. The goal of designing sustained release matrix delivery systems is to reduce frequency of dosing or to increase the effectiveness of the drug by localizing at the site of action, reducing the dose required, or providing uniform drug delivery. Hence, designing a sustained release formulation for an antihypertensive drug may prolong therapeutic concentration of drug in the blood and decrease the frequency of dosing and also improve the patient compliance. So in the present study, attempts will be made to formulate a sustained release matrix tablets containing an antihypertensive drug. In December 1843, a patent was granted to the Englishman, William Brockedon for a machine to compress powders to form compacts. This very simple device consisted essentially a hole (or die) bored through which the powder was compressed between the two cylindrical punches; one was inserted into the base of die and at a fixed depth, the other was inserted at the top of die and struck with hammer. The invention was first used to produce compacts of potassium bicarbonate and caught the imagination of no. of pharmaceutical companies. Later, welcome in Britain was the first company to use the term “tablet” to describe the compressed dosage form.
Download or read book Formulation And Evaluation Of Multilayer Matrix Tablet written by Ghanshyam Yadav and published by LAP Lambert Academic Publishing. This book was released on 2014-03 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study is carried out to design controlled release multilayered matrix tablets of antihypertensive drug. The aim of this research work is to reduce the frequency of dosing, decreasing the required dose employed, providing uniform drug delivery, reduction of side effects and enhancement of patient compliance of antihypertensive drug. The purpose of study to formulate and evaluate multi-layer matrix tablets using hydrophilic polymer, namely xanthan gum and chitosan by the wet granulation. Captopril was choosen as a model drug because of its higher water solubility. From the results obtained, the hydrophilic polymer xanthan gum and chitosan used individually could not sufficiently produce controlled release so must be combined in various ratios for effective oral controlled release to be achieved of multilayer matrix tablet that complied with all parameters. This book is a good guide for students who want to learn about formulation technology of multilayer matrix tablets along with their various evaluation parameters. This book will also work as a reference material for researchers, those are planning or already doing their research in this direction.
Download or read book Handbook of Pharmaceutical Controlled Release Technology written by Donald L. Wise and published by CRC Press. This book was released on 2000-08-24 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules!
Download or read book Particles and Nanoparticles in Pharmaceutical Products written by Henk G. Merkus and published by Springer. This book was released on 2018-09-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.
Download or read book Strategies to Modify the Drug Release from Pharmaceutical Systems written by Marcos Luciano Bruschi and published by Woodhead Publishing. This book was released on 2015-06-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Download or read book Sustained Release Tablets written by Akhtar Rasul and published by LAP Lambert Academic Publishing. This book was released on 2011-04 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The polymer was incorporated into a matrix system using direct compression technique. Different formulations were evaluated with respect to dissolution profile in 900 mL phosphate buffer (pH 6.8), 0.1 M HCl solution and distilled water for 12 h at 37°C. Increasing the amount of polymer (xanthan gum) in the formulation led to slow release of drug. The kinetic treatment showed the best fitted different mathematical models (Zero order, First order, Higuchiís and Hixson-Crowell). Most of the solid matrix formulations followed Higuchi or zero order kinetics. The formulations F1, F2, F3 and F7, F8, F9 showed maximum linearity. The results showed that the formulation F9 containing 30% xanthan gum and 10% gum tragacanth is the most similar to that of the reference marketed preparation.
Download or read book Aulton s Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
Download or read book Chemical Engineering in the Pharmaceutical Industry written by Mary T. am Ende and published by John Wiley & Sons. This book was released on 2019-04-08 with total page 1435 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.
Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.
Download or read book Hydrogels in Medicine and Pharmacy written by Nikolaos A. Peppas and published by CRC Press. This book was released on 2019-08-15 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1986, this book offers a full, comprehensive guide to the application of hydrogels in medicine. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine and other practitioners in their respective fields.
Download or read book In Vitro In Vivo Correlations written by David B. Young and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the invited presentations and some of the posters presented at the conference entitled "In Vitro-In Vivo Relationship (IVIVR) Workshop" held in Sep tember, 1996. The workshop was organized by the IVIVR Cooperative Working Group which has drawn together scientists from a number of organizations and institutions, both academic and industrial. In addition to Elan Corporation, which is a drug delivery com pany specializing in the development of ER (Extended Release) dosage forms, the IVIVR Cooperative Working Group consists of collaborators from the University of Maryland at Baltimore, University College Dublin, Trinity College Dublin, and the University of Not tingham in the UK. The principal collaborators are: Dr. Jackie Butler, Elan Corporation Prof. Owen Corrigan, Trinity College Dublin Dr. lain Cumming, Elan Corporation Dr. John Devane, Elan Corporation Dr. Adrian Dunne, University College Dublin Dr. Stuart Madden, Elan Corporation Dr. Colin Melia, University of Nottingham Mr. Tom O'Hara, Elan Corporation Dr. Deborah Piscitelli, University of Maryland at Baltimore Dr. Araz Raoof, Elan Corporation Mr. Paul Stark, Elan Corporation Dr. David Young, University of Maryland at Baltimore The purpose of the workshop was to discuss new concepts and methods in the devel opment of in vitro-in vivo relationships for ER products. The original idea went back ap proximately 15 months prior to the workshop itself. For some time, the principal collaborators had been working together on various aspects of dosage form development.
Download or read book Food Hydrocolloids written by Martin Glicksman and published by CRC Press. This book was released on 2020-03-27 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1982, this three-volume set explores the value of hydrocolloids in food. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for dieticians and other practitioners in their respective fields.
Download or read book Fundamentals and Applications of Controlled Release Drug Delivery written by Juergen Siepmann and published by Springer Science & Business Media. This book was released on 2011-12-15 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.
