Download or read book Hydrogen Peroxide and Cell Signaling Part B written by and published by Academic Press. This book was released on 2013-06-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates, and peroxiredoxins as preferential targets in H2O2-induced signaling. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers hydrogen peroxide and cell signaling - Contains chapters on such topics as the cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates, and peroxiredoxins as preferential targets in H2O2-induced signaling

Download or read book Hydrogen Peroxide and Cell Signaling Part A written by and published by Academic Press. This book was released on 2013-06-19 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers hydrogen peroxide and cell signaling - Contains chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer

Download or read book Hydrogen Peroxide and Cell Signaling Part C written by and published by Academic Press. This book was released on 2013-07-11 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers hydrogen peroxide and cell signaling - Contains chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy

Download or read book Hydrogen Peroxide and Cell Signaling Part A written by and published by Academic Press. This book was released on 2013-06-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers hydrogen peroxide and cell signaling - Contains chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer

Download or read book Hydrogen Peroxide Metabolism in Health and Disease written by Margreet C M Vissers and published by CRC Press. This book was released on 2017-10-19 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.

Download or read book Oxidative Stress written by Helmut Sies and published by Academic Press. This book was released on 2019-11-07 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: - A conceptual framework for studying oxidative stress. - Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). - The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. - Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. - Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine - Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies - Features contributions from international leaders in oxidative stress and redox biology research

Download or read book Nitric Oxide and Hydrogen Peroxide Signaling in Higher Plants written by Dharmendra K. Gupta and published by Springer. This book was released on 2019-03-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes nitric oxide (NO) and hydrogen peroxide (H2O2) functions in higher plants. Much progress has been made in the field of NO and H2O2 research regarding the various mechanisms and functions of these two molecules, particularly regarding stress tolerance and signaling processes, but there are still gaps to be filled. NO and H2O2 are both crucial regulators of development, and act as signaling molecules at each step of the plant lifecycle, while also playing important roles in biotic and abiotic responses to environmental cues. The book summarizes key advances in the field of NO and H2O2 research, focusing on a range of processes including: signaling, metabolism, seed germination, development, sexual reproduction, fruit ripening, and defense.

Download or read book Hydrogen Peroxide and Cell Signaling written by Enrique Cadenas and published by . This book was released on 2013 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oxidative Stress and Signal Transduction written by H.J. Forman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Download or read book Peroxiredoxins as Redox Sensors and Mediators of Oxidant Dependent Cell Signaling written by Timothy J. Phalen and published by . This book was released on 2007 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) have been shown to play an important and unique role in mitogenic signaling pathways that govern cell proliferation in response to growth factors. The production of hydrogen peroxide (H2O2) by mitochondria and NADPH oxidases participate in mitogenic signaling by altering the fhnction of specific protein components along the transduction pathway, including kinases, phosphatases, and transcription factors. The levels of H2O2 and other ROS are regulated in part by a variety of small molecule antioxidants and antioxidant enzyme systems which are incorporated into an intricate redox signaling network that controls diverse cell processes. Two-Cys peroxiredoxins (2-Cys Prxs) are abundantly expressed, highly conserved peroxidase enzymes that actively regulate several cell signaling pathways by modulating H2O2 levels, and by altering the activity of signaling components via direct protein-protein interactions. Although eukaryotic 2-Cys Prxs have a high affinity for hydroperoxides, they can become temporarily inactivated through hyperoxidation of one of the active site cysteines, thereby forming a sulfinic acid (Prx-SO2H). 2-Cys Prxs undergo redox-coupled conformational changes that govern oligomeric organization. Hyperoxidation and other factors promote the formation of high molecular weight (HMW) complexes consisting of multiple 2-Cys Prx decamers. The role of 2-Cys Prxs in cell cycle reentry and recovery from cell cycle arrest was investigated using a cell culture model in which quiescent cells are induced to reenter the cell cycle by stimulation with medium containing 10% fetal bovine serum (FBS). Serum stimulation of quiescent mouse C10 lung epithelial cells induced the rapid formation of PrxI and PrxII homodimers, indicating that the PrxI and II catalytic cycles are engaged by mitogenic H2O2 production. Hyperoxidation of PrxI and I1 in response to serum was not observed, indicating that 2-Cys Prx inactivation is not required for mitogenic signaling. An H2O2 generating system, glucose oxidase (GOx), was used to examine the dose-dependent effects of H2O2 on cell cycle progression and arrest as measured by cyclin D1 expression. Doses of H2O2 that induced quantitative hyperoxidation of PrxI did not block expression of cyclin D1. Inhibition of cyclin D1 expression and cell cycle arrest did not occur until cells were treated with a threshold dose of H2O2 that caused formation of HMW PrxII-SO2H complexes that appeared to associate with the actin cytoskeleton. When GOx was removed and cells were allowed to recover, cyclin Dl expression and resumption of cell cycle progression correlated with retroreduction of hyperoxidized PrxII and disruption HMW PrxII-SO2H complexes. Ectopic expression of PrxI and II did not rescue C10 cells from H2O2 induced cell cycle arrest, but rather increased the total cellular burden of hyperoxidized PrxI and II, and delayed recovery of cyclin Dl expression and cell cycle progression. These results indicate that hyperoxidation of PrxII may serve as a warning signal for perturbations in H2O2 metabolism during mitogenic signaling. Here it is proposed that 2-Cys Prxs act as peroxide dosimeters in which oxidation-coupled structural and oligomeric transitions serve as the mechanism by which they sense and relay changes in subcellular redox stahls to cell signaling machinery.

Download or read book Signal Transduction by Reactive Oxygen and Nitrogen Species Pathways and Chemical Principles written by H.J. Forman and published by Springer Science & Business. This book was released on 2006-02-17 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Download or read book Peroxiredoxin Systems written by Leopold Flohé and published by Springer Science & Business Media. This book was released on 2007-09-04 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a broad survey on the peroxiredoxins. It involves almost all groups that contributed significant insights into the emerging field. Coverage discusses the diverse biological roles of the new protein family in the context of other antioxidant systems like those based on heme or selenium catalysis. In addition, the book highlights related future perspectives.

Download or read book Oxidative Stress in Vertebrates and Invertebrates written by Tahira Farooqui and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Download or read book Molecular Imaging Approaches to Understanding the Roles of Hydrogen Peroxide Biology in Stress and Development written by Bryan Craig Dickinson and published by . This book was released on 2010 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The production of hydrogen peroxide (H2O2) in biological systems is associated with a variety of pathologies including neurodegenerative diseases, cancer, and the general process of aging. However, a growing body of evidence suggests that the reactivity of this particular reactive oxygen species (ROS) is also harnessed for physiological processes. Molecular imaging using fluorescence microscopy offers a valuable approach for deciphering the multifaceted roles of H2O2 in biological processes. The use of aryl boronates for the selective detection of H2O2 in biological systems is a validated approach to the development of H2O2-responsive fluorophores. This dissertation describes the design, synthesis, and characterization of an assortment of new boronate-based fluorescent probes for H2O2, as well as their application toward uncovering new roles for H2O2 in stress and development. Peroxyfluor-2, Peroxyfluor-3, Peroxy Yellow 1, and Peroxy Orange 1 are turn-on fluorescent probes that can detect physiological levels of H2O2 produced for cell signaling, as well as monitor multiple ROS simultaneously in single cells. Mitochondria Peroxy Yellow 1 is a bifunctional probe featuring a triphenylphosphonium group for mitochondrial targeting and a single boronate for H2O2 detection that allows for the detection of mitochondrial H2O2 associated with a Parkinson's diseases model. Nuclear Peroxy Emerald 1 is a nuclear-targeted probe that reveals Sirtuin-dependent changes in nuclear H2O2 metabolism in C. Elegans. Peroxyfluor-6 (PF6) is a bifunctional probe featuring acetoxymethylester-protected phenol and carboxylic acid functionalities for enhanced cellular uptake and retention. PF6 reveals endogenous H2O2 production within neural stem cells and molecular biological experiments expose a new role for H2O2 in growth signaling within this critical brain cell population in vitro and in vivo. Finally, Peroxy Yellow 1 Methyl-Ester, a probe designed for analysis by flow cytometry, reveals that Aquaporins 3 and 8, but not Aquaporin 1, can mediate H2O2 uptake across the plasma membrane of mammalian cells, and that Aquaporin 3 can facilitate the uptake of endogenous H2O2 relevant to cell signaling.

Download or read book Decontamination in Hospitals and Healthcare written by James T. Walker and published by Woodhead Publishing. This book was released on 2019-11-26 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decontamination in Hospitals and Healthcare, Second Edition, enables users to obtain detailed knowledge of decontamination practices in healthcare settings, including surfaces, devices, clothing and people, with a specific focus on hospitals and dental clinics. - Offers in-depth coverage of all aspects of decontamination in healthcare - Examines the decontamination of surgical equipment and endoscopes - Expanded to include new information on behavioral principles in decontamination, control of microbiological problems, waterborne microorganisms, pseudomonas and the decontamination of laundry

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reactive Oxygen Species in Plants written by Vijay Pratap Singh and published by John Wiley & Sons. This book was released on 2017-10-11 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the basics of ROS metabolism in plants and examines the broad range of ROS signaling mechanisms New discoveries about the effects of reactive oxygen species (ROS) on plants have turned ROS from being considered a bane into a boon, because their roles have been discovered in many plant developmental processes as signaling molecules. This comprehensive book teaches about the role of ROS metabolism in plants and how they affect various developmental processes. It also discusses in detail the advancements made in understanding the ROS signaling. Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS begins by presenting the basic introduction to ROS and deciphers the detailed knowledge in ROS research. It then examines the broad range of ROS signaling mechanisms as well as how they may be beneficial for plants and human beings. This book also describes both the bane and boon aspects of ROS with their impact on plants, and how the recent revelations have compelled us to rethink ROS turning from stressors to plant regulators. ● Compiles, for the first time, the wholesome knowledge in ROS research and their cellular signaling ● Includes new discoveries and in-depth discussions about the advancements made in the field ● Discusses reactive oxygen species which are involved in a broad range of biological processes Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS will help scientists to utilize the functions of ROS signaling for plants and also enable readers to gain a deeper knowledge of ROS research and signaling. It is highly recommended for researchers, scientists, and academicians in plant science as well for advanced undergraduate and postgraduate students.