Download or read book Human Insulin written by D.R. Owens and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.

Download or read book The Discovery of Insulin written by Michael Bliss and published by University of Toronto Press. This book was released on 2017-06-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.

Download or read book Insulin written by Arthur Teuscher and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s synthetic 'human' insulin produced by recombinant DNA technology came onto the market. Despite an acknowledgment by the manufacturers regarding the potential dangers of 'human' insulin they soon began to withdraw bovine and porcine insulin from markets all over the world, and promoted more expensive 'human' insulins as a superior replacement. Diabetics had no option but to effectively switch to the new synthetic insulins and often they received little or no information about their potentially life-threatening side effects. In the first part of this book the author provides fundamental information about insulin therapy and its history. A detailed discussion of the hazards confronting some diabetic patients when using 'human' insulin follows. Due to more pronounced hypoglycemia symptoms animal insulin can be regarded as safer than 'human' insulin for 10-20% of diabetic patients. The last part of this publication looks at the pharmaceutical industry's decision to withdraw animal insulin from the market and describes the struggles of a new global movement to secure its continued availability. This book not only provides potentially vital background information for those who depend on insulin, but also deserves the attention of professionals who prescribe or distribute this medication. It can also serve as a reference for patient advocates, relevant government departments and pharmaceutical companies.

Download or read book Invisible Frontiers written by Stephen S. Hall and published by Oxford University Press, USA. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Author Stephen Hall weaves together the scientific, social and political threads of this story - the fierce rivalry between labs, the fateful clash of egos within labs, the invasion of academia by commerce, the public fears about genetic engineering, the threat of government regulation, and the ultimate triumph of modern biology - to give us an outstanding tale of scientific research."--BOOK JACKET.

Download or read book Insulin Therapy written by William T. Cefalu and published by CRC Press. This book was released on 2002-03-22 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides how-to guidelines for inpatient and outpatient insulin therapy in children and adults and during pregnancy and in hyperglycemic emergencies. Evaluating strategies for the management of types 1 and 2 diabetes, this reference explores the pharmacokinetics of insulin and insulin programs as well as the latest glucose self-monitoring eq

Download or read book Galenics of Insulin written by Jens Brange and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Galenical pharmacy or galenics is the science dealing with the pro duction of drug substances from raw materials, the purity of such substances, their formulation into pharmaceutical preparations with the desired effects and safety in use, and the quality control, stability and storage of the preparations. The field has taken its name from the Greek physician Galen (131-201 A.D.), who had a profound influence on medicine for many centuries because he collected and systematized the medicinal knowledge of his time. The discovery of insulin is attributed to Banting and Best who, in 1921, prepared an extract of the pancreas of the fetal calf and showed that the extract was capable of reducing the blood sugar level of a diabetic dog. This outstanding discovery gave rise to the rapid develop ment of the manufacture of insulin of bovine and porcine origin. By 1925, two Danish manufacturers of insulin preparations were established; both have since been in the forefront ofthe development of insulin preparations, the latest achievement being the marketing of human insulin by Novo in 1982. The development of highly purified human insulin produced semisynthetically from porcine insulin or by DNA recombinant methods are significant contributions to safe and efficient insulin therapy. Insulin is a protein which is destroyed in the gastrointestinal tract.

Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Download or read book Practical Insulin written by American Diabetes Association and published by American Diabetes Association. This book was released on 2015-07-14 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of Practical Insulin: A Handbook for Prescribing Providers is a completely revised version of the popular ADA pocket reference. With information on all the currently FDA-approved insulins, this handy pocket guide gives you fast, reliable information and helps you overcome the challenges all clinicians face—choosing an insulin regimen to effectively manage blood glucose and patient resistance. It includes data on all types of insulin, mixing insulins, absorption rates, and more.

Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Download or read book Insulin Therapy written by Mark W. J. Strachan and published by Springer Science & Business Media. This book was released on 2013-02-20 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide clear and concise information about the safe prescribing of insulin both subcutaneously and intravenously. It provides information on the different types of insulin, the delivery devices, side effects of insulin and, most importantly, on rational dose adjustment.​

Download or read book Human Insulin by Tryptic Transpeptidations of Porcine Insulin and Biosynthetic Precursors written by Jan Markussen and published by Springer. This book was released on 1987 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Insulin written by Andrew J. Krentz and published by Academic Press. This book was released on 2024-01-18 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and insulin-sensitizing drugs. Notable advances in precision diagnosis and therapy for single gene subtypes of diabetes in recent years are also discussed. The discovery of insulin and its lifesaving introduction into clinical practice is one of the most celebrated accomplishments of medical science. However, despite decades of progress and major technical advances, the goal of providing insulin replacement therapy that truly mimics normal physiology remains elusive. Presents etiology and pathogenesis of insulin deficiency, insulin excess and insulin resistance in a wide spectrum of human diseases, ranging from rare to highly prevalent disorders Discusses the latest developments in the diagnosis and management of insulin-related disorders and prospects for future developments Explores the increasingly complex pharmacological landscape that comprises a bewildering range of drug-based interventions

Download or read book Human Insulin by Tryptic Transpeptidations of Porcine Insulin and Biosynthetic Precursors written by J. Markusse and published by Springer. This book was released on 2014-09-12 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diabetes Insulin Dependent written by Professor Kinga Howorka M.D. and published by Xlibris Corporation. This book was released on 2011-01-18 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-dependent?... In addition to the introduction to Functional Insulin Treatment for physicians (K. Howorka, Springer Publishers Berlin), this book presents guidelines for people with diabetes to treat their condition using Functional Insulin Treatment. Only after meticulous reading of this manual does it become clear, how many already well-known facts and other things that have never been heard of before, have been put here together in a methodological whole. Contradictions that you may have experienced personally suddenly become strikingly clear in this context. After a short self-testing period with FIT, the fear of completely inexplicable blips in your blood glucose is overcome, and you can feel selfassured, since you know the causes and provide solutions. FIT is the most modern and effective method to facilitate the control of insulin requiring diabetes. With FIT, sometimes you do not even have to know the basics on how to multiply. Philosophies and esoteric recommendations are replaced by a couple of numbers with which you can calculate. Although the problems remain the same, FIT offers you an intelligent and practical possibility of solving them by summarizing all of the treatment possibilities available today. W.D., after 48 years with diabetes DiabetesFIT is a registered trademark for Functional Insulin Treatment, related media and education. ...only with Dr. Howorkas FIT therapy I was able to ascend the Mount Everest, the highest mountain of the world and to fulfill the dream of my life... Geri Winkler. Extreme sportsman and teacher with diabetes, http://www.winklerworld.net

Download or read book Insulin Therapy An Issue of Endocrinology and Metabolism Clinics E Book written by John L. Leahy and published by Elsevier Health Sciences. This book was released on 2012-03-28 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Endocrinology Clinics brings the reader up do date on the current standards and important advances in insulin therapy. The following clinical topics are discussed: types of insulins, including new insulins; goals of therapy; pathophysiology of, and insulin treatment in type1 and type 2 diabetes mellitus; pumps and glucose sensors; alternative insulin delivery; patient and provider insulin resistance; inpatient insulin therapy; insulin therapy in pregnancy; and pediatric insulin therapy.

Download or read book Full Life With Diabetes written by Arvind Godbole and published by Popular Prakashan. This book was released on 1976 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ultimate Guide to Insulin written by Gaffar Zaman and published by . This book was released on 2019-02-06 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a qualitative and quantitative approach to understand, manage and enforce the integration of insulin into diabetes mellitus. Utilizing a sound theoretical and practical foundation and illustrating procedural techniques through scientific examples, the book bridges the gap between insulin and diabetes mellitus management. Detailed procedures have been omitted because of the variety of equipment and commercial kits used in today's clinical laboratories.