Download or read book Human Apolipoprotein Mutants written by C. R. Sirtori and published by Springer. This book was released on 2014-11-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Apolipoprotein Mutants III written by Cesare R. Sirtori and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.

Download or read book Human Apolipoprotein Mutants 2 written by Cesare Sirtori and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pleasant community of Limone suI Garda provided outstanding hospitality for a second NATO ARW dealing with apolipoprotein variants, which are natures clues for the discovery of the physiological roles of apolipoproteins in lipoprotein metabolism in normal subjects and patients with specific dyslipoproteinemias. Limone, the site of discovery of the first human apolipoprotein mutant, apoA-I-Milano, provided a brilliant sunny spring venue for more than 50 participants from both sides of the ocean. The attendance at the colorful opening ceremony of the ARW was one of the largest on record. Two members of the Italian government, the Secretaries of Health and the Navy, gave the welcoming addresses. Six television networks, two with national audiences, covered the international workshop. The Limone oracles provided a montage of insights gleamed from the eyes of the clinican, the biochemist, and the molecular biologist. The cumulative information on the molecular defects in lipoprotein metabolism reviewed by this diverse group of investigators provided an ever expanding horizon of new knowledge in this fast moving and some times perplexing field. Clinical vignettes were presented on patients from throughout the world including Canada (Connelly), Turkey (Schmitz), and France (Infante) detailing the clinical sequelae of a defect in a specific apolipoprotein. The clinical importance of Lp(a), a lipoprotein relegated almost to obscurity for many years, has now taken v center stage.

Download or read book Apolipoprotein E and Alzheimer s Disease written by A.D. Roses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Download or read book Structure and Function of Apolipoproteins written by Maryvonne Rosseneu and published by CRC Press. This book was released on 1992-08-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Function of Apolipoproteins presents a comprehensive review of the primary and secondary structure of apolipoproteins. The book discusses the structure of the apolipoprotein gene family and genetic variation occurring at the protein level. Functional properties of apolipoproteins, including lipid binding, enzyme co-factor activity, antigenic properties, and receptor-ligand interactions are extensively described and analyzed in relation to their structural features. Physiological properties of apolipoproteins and their role in biology and medicine are also examined. Anyone who is interested in apolipoproteins or is conducting research on atherosclerosis should consider this volume an essential reference.

Download or read book High Density Lipoproteins written by Arnold von Eckardstein and published by Springer. This book was released on 2015-01-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

Download or read book Human apolipoprotein mutants written by and published by . This book was released on 1989 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Metabolic Basis of Inherited Disease written by Charles R. Scriver and published by . This book was released on 1989 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dyslipidemias written by Abhimanyu Garg and published by Springer. This book was released on 2015-05-11 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Program’s Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.

Download or read book High Density Lipoproteins Dyslipidemia and Coronary Heart Disease written by Ernst J. Schaefer and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative book focuses on HDL and its relationships to triglyceride-rich particles. It is an excellent resource for educating physicians and scientists about dyslipidemia and HDL metabolism, including many exogenous substances which interact with and influence HDL.

Download or read book Current Bibliographies in Medicine written by and published by . This book was released on 1988 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Published Scientific Papers of the National Institutes of Health written by National Institutes of Health (U.S.) and published by . This book was released on 1990 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1985 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Apolipoproteins A Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Apolipoproteins A Research and Application / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Apolipoproteins A in a compact format. The editors have built Advances in Apolipoproteins A Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Apolipoproteins A in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Apolipoproteins A Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Inherited Metabolic Disease in Adults written by Carla E. M. Hollak and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.

Download or read book Lipids in Protein Misfolding written by Olga Gursky and published by Springer. This book was released on 2015-07-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se