Download or read book Host Pathogen Interactions During Arboviral Infections written by Alan G. Goodman and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arboviruses, or arthropod-borne viruses, such as West Nile virus, Dengue virus, and Zika virus, pose a serious threat to public health worldwide. West Nile virus was introduced to the United States in 1999, and is now endemic, causing over 2,000 domestically acquired cases in the U.S. annually in mammals. Similarly, dengue and Zika viruses are endemic in the Americas and pose novel threats to the human population. Tick-borne viruses such as Powassan virus and Heartland virus are increasing in frequency in the U.S. At this time, there is no commercially available vaccine or therapeutic to treat these viral infections. Because nearly every mammalian case of these virus infections originates from the insect vector, it is imperative that we also understand viral pathogenesis, transmission, and the immune response in insect models as well as pathogenesis and the host responses in infected mammals. The development of methods to block arbovirus transmission from the vector may be effective at ceasing arthropod-to-human infection since the current recommendation to prevent these viral infections is to decrease contact with mosquitoes. Additionally, improving our understanding of epidemiology and ecology will also help develop measures to reduce virus spread. In order to better study mammalian and insect host responses to infection, a number of genetic tools are available, such as fly, mosquito, and tick models, recombinant viruses, mouse models, and bioinformatics tools. The studies described in this eBook will illustrate host responses to infection using mammalian and insect models, identify critical signaling nodes of the innate immune response, and discuss virus transmission from insect to mammal or among infected hosts. Taken together, these studies will elucidate means of decreasing infections in human populations and provide potential targets for future study and therapeutic design.
Download or read book Host Pathogen Interactions written by Steffen Rupp and published by Humana Press. This book was released on 2008-11-01 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, infectious diseases, once believed to be fairly contained, have become a vital, resurgent field of research. In Host-Pathogen Interactions: Methods and Protocols, top experts examine the relationship between the host and the pathogen, crucial in the outcome of an infection and the establishment of disease or asymptomatic, commensal colonization by organisms. The step-by-step laboratory methods and protocols of this volume study host-pathogen interaction, with a focus on fungal, bacterial and parasitic pathogens, at a molecular level in order to reveal the mechanisms of infection and to identify the vulnerabilities of the pathogen of interest. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters feature brief subject introductions, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Host-Pathogen Interactions: Methods and Protocols serves as an easy entry point for all those investigating the factors responsible for the pathogenicity of microorganisms.
Download or read book Molecular Aspects of Host Pathogen Interactions written by Society for General Microbiology. Symposium and published by Cambridge University Press. This book was released on 1997-05-13 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports the latest advances in defining the molecular basis of infection in both bacterial and viral systems.
Download or read book Tuberculosis Host pathogen Interactions written by Jeffrey David Cirillo and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-the-art advances related to our understanding of how this organism causes disease in humans, its mechanisms involved in parasitizing the host, as well as how the host resists or becomes susceptible to infection. We cover several of the molecular, biochemical and structural aspects of the bacterium responsible, Mycobacterium tuberculosis, and describe individual components of the host response and how these impact the course of disease. Although we cover only a very small portion of the field in this overview, we believe that there is a great deal of novel information present that will be valuable to any researcher or student of the field. We are at a stage where there are often more questions than answers, but use of the foundation that is now developing through the effort of tuberculosis researchers provides us with opportunities previously out of reach. This text provides overviews of the field in a number of different areas that will engage researchers interested in tuberculosis, and provide suggestions for ways to move forward. All of the authors hope that readers enjoy this taste of each area, and that their contributions will help others to make additional progress. Dr. Jeffrey D. Cirillo is a Regents Professor at Texas A & M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis. Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.
Download or read book Global Health Impacts of Vector Borne Diseases written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-21 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.
Download or read book Arboviruses written by Nikos Vasilakis and published by Caister Academic Press Limited. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthropod-borne viruses (arboviruses) are the causative agents of significant morbidity and mortality among humans and domestic animals globally. They are maintained in complex biological life cycles, involving a primary vertebrate host and a primary arthropod vector. While all known arboviruses are zoonotic pathogens, their emergence as human pathogens is associated with dramatic increases of human population growth leading to uncontrolled urbanization, changes in land and water use, changes in agricultural practices, new irrigation systems and deforestation. This book brings together a panel of expert arbovirologists to produce a timely review of the rapidly expanding arbovirus research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: taxonomy, genome organization, virus-host and virus-vector interactions, evolutionary history, role of vertical transmission in arbovirus maintenance and evolution, epidemiology, arbovirus replication, pathogenesis, arbovirus diagnostics and control, including vaccines, novel anti-viral drugs, RNA interference and genetically modified vectors. Essential reading for every arbovirologist and highly recommended for all virologists and public health officials. [Subject: Microbiology, Life Science, Arbovirology, Virology, Taxonomy, Epidemiology]
Download or read book Advanced Concepts in Human Immunology Prospects for Disease Control written by Pooja Jain and published by Springer Nature. This book was released on 2020-08-11 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
Download or read book Emerging Viral Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2015-03-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.
Download or read book Skin and Arthropod Vectors written by Nathalie Boulanger and published by Academic Press. This book was released on 2018-01-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity
Download or read book Biology of Disease Vectors written by William H. Marquardt and published by Elsevier. This book was released on 2004-12-04 with total page 811 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Disease Vectors presents a comprehensive and advanced discussion of disease vectors and what the future may hold for their control. This edition examines the control of disease vectors through topics such as general biological requirements of vectors, epidemiology, physiology and molecular biology, genetics, principles of control and insecticide resistance. Methods of maintaining vectors in the laboratory are also described in detail.No other single volume includes both basic information on vectors, as well as chapters on cutting-edge topics, authored by the leading experts in the field. The first edition of Biology of Disease Vectors was a landmark text, and this edition promises to have even more impact as a reference for current thought and techniques in vector biology. Current - each chapter represents the present state of knowledge in the subject areaAuthoritative - authors include leading researchers in the fieldComplete - provides both independent investigator and the student with a single reference volume which adopts an explicitly evolutionary viewpoint throuoghout all chapters. Useful - conceptual frameworks for all subject areas include crucial information needed for application to difficult problems of controlling vector-borne diseases
Download or read book Tick Host Pathogen Interactions written by Sarah Irène Bonnet and published by Frontiers Media SA. This book was released on 2018-08-24 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.
Download or read book Laboratory Diagnosis of Infectious Diseases Principles and Practice written by Edwin H. Lennette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 983 pages. Available in PDF, EPUB and Kindle. Book excerpt: those who deal with infectious diseases on a daily This two volume work stems from the belief of the Editors that infectious diseases are not only very basis. much with us today but, more importantly, that they There are several excellent textbooks dealing will continue to playa significant global role in mor with medical microbiology, and there are equally bidity and mortality in all people. A continuing need well-recognized books devoted to infectious dis for an informed and knowledgeable community of eases. The Editors of this work, on the other hand, were persuaded that there was a need for a publica laboratory scientists is fundamental. Data describing tion that would bring together the most pertinent and the global impact of infectious diseases are difficult to come by. Fortunately, a recent thoughtful and relevant information on the principles and practice of provocative publication by Bennett et al. (1987) pro the laboratory diagnosis of infectious diseases and vides us with data derived from several consultants include clinical relationships. While this two volume that clearly delineate the impact of infectious dis text is directed toward the role of the laboratory in eases on the United States today.
Download or read book Host pathogen Interaction in Central Nervous System Infection written by Federico Iovino and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2022-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.
Download or read book Hantaviruses written by C. Schmaljohn and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hantaviruses are found world-wide and are associated with two severe disease syndromes, hemorrhagic fever and hantavirus pulmonary syndrome. The recent studies in this volume provide a basis for understanding the high human pathogenicity of theses viruses and their continued maintenance and transmission within rodent populations.
Download or read book Public Health written by Md Anwarul Azim Majumder and published by BoD – Books on Demand. This book was released on 2018-10-17 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of modern public health is to improve the quality of life and promote health for all. Public health deals with a wide range of individuals and collaborates with various organizations, departments, and agencies to improve health, forestall disease and promote well-being. The field of public health is constantly evolving in response to the needs of communities and populations that are facing demographic, epidemiological and technological challenges. To overcome these challenges, health professionals need to conduct research to generate evidence-based policies to improve the health of the community. Throughout the course of this book, a number of emerging and re-emerging public health issues from different countries are discussed and attempts are made to illustrate a balanced and evidence-based approach towards tackling major public health problems.
Download or read book The New Public Health written by Theodore H. Tulchinsky and published by Academic Press. This book was released on 2014-03-26 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Public Health has established itself as a solid textbook throughout the world. Translated into 7 languages, this work distinguishes itself from other public health textbooks, which are either highly locally oriented or, if international, lack the specificity of local issues relevant to students' understanding of applied public health in their own setting. This 3e provides a unified approach to public health appropriate for all masters' level students and practitioners—specifically for courses in MPH programs, community health and preventive medicine programs, community health education programs, and community health nursing programs, as well as programs for other medical professionals such as pharmacy, physiotherapy, and other public health courses. Changes in infectious and chronic disease epidemiology including vaccines, health promotion, human resources for health and health technology Lessons from H1N1, pandemic threats, disease eradication, nutritional health Trends of health systems and reforms and consequences of current economic crisis for health Public health law, ethics, scientific d health technology advances and assessment Global Health environment, Millennium Development Goals and international NGOs
