Download or read book Hormones in Neurodegeneration Neuroprotection and Neurogenesis written by Achille G. Gravanis and published by John Wiley & Sons. This book was released on 2011-06-24 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.
Download or read book Sex Hormones in Neurodegenerative Processes and Diseases written by Gorazd Drevensek and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.
Download or read book Hormones Cognition and Dementia written by Eef Hogervorst and published by . This book was released on 2014-05-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.
Download or read book Sex and Gender Differences in Alzheimer s Disease written by Maria Teresa Ferretti and published by Academic Press. This book was released on 2021-07-23 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer’s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel
Download or read book New Insights Into Adult Neurogenesis and Neurodegeneration Challenges for Brain Repair written by Jose Angel Morales-Garcia and published by Frontiers Media SA. This book was released on 2022-04-04 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Regulation Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Download or read book The Female Brain written by Louann Brizendine, MD and published by Harmony. This book was released on 2007-08-07 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Dr. Brizendine wrote The Female Brain ten years ago, the response has been overwhelming. This New York Times bestseller has been translated into more than thirty languages, has sold nearly a million copies between editions, and has most recently inspired a romantic comedy starring Whitney Cummings and Sofia Vergara. And its profound scientific understanding of the nature and experience of the female brain continues to guide women as they pass through life stages, to help men better understand the girls and women in their lives, and to illuminate the delicate emotional machinery of a love relationship. Why are women more verbal than men? Why do women remember details of fights that men can’t remember at all? Why do women tend to form deeper bonds with their female friends than men do with their male counterparts? These and other questions have stumped both sexes throughout the ages. Now, pioneering neuropsychiatrist Louann Brizendine, M.D., brings together the latest findings to show how the unique structure of the female brain determines how women think, what they value, how they communicate, and who they love. While doing research as a medical student at Yale and then as a resident and faculty member at Harvard, Louann Brizendine discovered that almost all of the clinical data in existence on neurology, psychology, and neurobiology focused exclusively on males. In response to the overwhelming need for information on the female mind, Brizendine established the first clinic in the country to study and treat women’s brain function. In The Female Brain, Dr. Brizendine distills all her findings and the latest information from the scientific community in a highly accessible book that educates women about their unique brain/body/behavior. The result: women will come away from this book knowing that they have a lean, mean, communicating machine. Men will develop a serious case of brain envy.
Download or read book Hormones and Brain Plasticity written by Luis Miguel Garcia-Segura and published by Oxford University Press. This book was released on 2009-05-05 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones, brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism.Garcia-Segura argues that hormones are indispensable for adequately adapting the endogenous neuroplastic activity of the brain to the incessant modifications in external and internal environments. Their regulation of neuroplastic events in a given moment predetermines new neuroplastic responses that will occur in the future, adapting brain reorganization to changing physiological and behavioral demands throughout the life of the organism. The cross-regulation of brain plasticity and hormones integrates information originated in multiple endocrine glands and body organs with information coming from the external world in conjunction with the previous history of the organism. Multiple hormonal signals act in concert to regulate the generation of morphological and functional changes in neural cells, as well as the replacement of neurons, glial, and endothelial cells in neural networks. Brain remodeling, in turn, is involved in controlling the activity of the endocrine glands and regulating hormonal secretions. This bidirectional adjustment of brain plasticity in response to hormonal inputs, and adjustment of hormonal concentrations in response to neuroplastic events are crucial for maintaining the stability of the inner milieu and for the generation of adequate behavioral responses in anticipation of--and in adaptation to--new social and environmental circumstances and life events, including pathological conditions.
Download or read book Neurodegeneration and Alzheimer s Disease written by Ralph N. Martins and published by John Wiley & Sons. This book was released on 2019-07-10 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Download or read book Neurogenesis and Neural Plasticity written by Catherine Belzung and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.
Download or read book Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders written by Akhlaq A. Farooqui and published by Academic Press. This book was released on 2020-09-07 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders
Download or read book Lipids and Cellular Membranes in Amyloid Diseases written by Raz Jelinek and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders. From the contents: * Interactions of Alpha-Synuclein with Lipids * Interaction of hIAPP and its Precursors with Membranes * Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine * The Role of Lipid Rafts in Alzheimer's Disease * Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases * Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease * Membrane Changes in BSE and Scrapie * Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions and more
Download or read book Systems Biology of Free Radicals and Antioxidants written by Ismail Laher and published by Springer. This book was released on 2014-06-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Download or read book Steroids and the Nervous System written by GianCarlo Panzica and published by . This book was released on 2003 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.
Download or read book Molecular Mechanisms of Hormone Actions on Behavior written by Anne M. Etgen and published by Academic Press. This book was released on 2010-03-16 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth.Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x,y z Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions Heavily illustrated with 175 figures, approximately 54 in color Presents material in most visually useful form for the reader
Download or read book Rapid Eye Movement Sleep written by MallIck/Inoue and published by CRC Press. This book was released on 1999-06-29 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference also includes nine color plates. Written by leading international scientists in the field, this comprehensive and up-to-date reference provides detailed coverage of various aspects of rapid eye movement sleep (REMS)-including phylogeny and evolution, ontogeny, neurophysiological and neurochemical phenomena, molecular processes, behavioral and physiological changes due to deprivation, and hypotheses on the neurodynamics of REMS. Examining the relationship between the neocortex in mammals and birds in the evolution of REM sleep, Rapid Eye Movement Sleep considers the roles of REMS in the maturation of the brain reveals a new theory that challenges the assumption that REM is solely initiated by bulbar mechanisms in intact animals explores experimental studies of REMS atonia and the mechanisms underlying tonic and phasic muscle atonia describes the cellular and molecular mechanisms and function of pontine ponto-geniculo-occipatal waves during REMS details the role of nitric oxide in the regulation of REMS summarizes new evidence on which neurotransmitters are responsible for the REMS generating mechanism presents an overview of several endogenous sleep substances that may positively or negatively regulate REMS and more. Rapid Eye Movement Sleep serves as essential reading for all researchers and clinicians in the study of sleep science, particularly physiologists and biologists; neurologists, neuropsychiatrists, psychiatrists, and psychologists; anesethiologists; and pharmacologists.
