Download or read book Hormone Resistance and Other Endocrine Paradoxes written by Margo P Cohen and published by . This book was released on 1987-10-01 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hormone Resistance and Other Endocrine Paradoxes written by Margo P. Cohen and published by Springer Verlag. This book was released on 1987 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first in a new series entitled "Endocrinology and Metabolism: Progress in Research and Clinical Practice." It explores a wide range of clinical conditions in terms of the challenge they pose to current concepts in endocrinology. These conditions include pseudohypoparathyroidism, characterized by target organ resistance to parathyroid hormone; vitamin D resistance syndromes associated with calcitriol receptor abnormalities; and androgen sensivity syndromes in which normal testicular androgen synthesis and secretion coexist with phenotypic feminization. The endocrine paradox phenomenon is further elucidated through comprehensive discussions of the pathophysiology and treatment of major disorders in mineral homeostasis due to aldosterone deficiency and pseudodeficiency (with emphasis on hormonal derangements in Bartter's syndrome); euthyroid hyperoxinemia; and clinical and physiologic implications of insulin gene mutations and subsequent defects in insulin biosynthesis.

Download or read book Hormone Resistance and Other Endocrine Paradoxes written by Margo P. Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrinology and Metabolism: Progress in Research and Clinical Prac tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata gems.

Download or read book The Thyroid Paradox written by James K. Rone and published by ReadHowYouWant.com. This book was released on 2010-01-07 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Don't be satisfied with business-as-usual health care. If you suffer low thyroid - or think you might - and want to learn more, especially if you're unsatisfied with the answers you're getting from your doctor, this book is for you. An estimated 5.8% of women and 3.4% of men in the United States are hypothyroid. Low thyroid is common, yet, paradoxically, may be rampantly overlooked. Why? As you'll discover in The Thyroid Paradox, there is a pervasive oversimplification of thyroid science and mainstream treatment of thyroid patients today. Current thyroid testing has weaknesses and should be interpreted, not in a vacuum, but as part of a diagnostic process based on all the evidence. Too often, doctors simply stick to test results and miss patients suffering with subtle hypothyroidism. The Thyroid Paradox is for the person who's been told ''It's not your thyroid, '' without then being told convincingly what it is. Maybe you've been told nothing is wrong but know there must be some reason for your chronic fatigue, body aches, weight gain, dry skin, constipation, ''brain fog, '' depression, or menstrual irregularity. This book provides the answers for you. You'll learn about: The loopholes in current thyroid testing; Hidden forms of hypothyroidism and how to detect them; The best strategies for thyroid replacement. The path out of the thyroid paradox is engaged teamwork involving both doctor and patient. This book should provide you with the knowledge you need to communicate and work with your doctor to get the treatment you deserve.

Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Endocrinology Second Edition written by George H. Gass and published by CRC Press. This book was released on 1996-06-17 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stay on top of the rapid changes sweeping endocrinology today with the latest information on important selected topics in The Handbook of Endocrinology. This extensive two-volume text provides an impressive breadth and depth of coverage difficult to find in other sources. After a broad survey of the functions of major endocrine glands, the book launches into detailed reviews of both established and hot, new research areas. Selected topics include:

Download or read book Gene Engineering in Endocrinology written by Margaret A. Shupnik and published by Springer Science & Business Media. This book was released on 2000-04-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated “orphan rec- tors,” such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors—including those for thyroid hormone, estrogens, androgens, and progesterone—were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1988 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recent Progress in Hormone Research written by James H. Clark and published by Academic Press. This book was released on 2013-10-22 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Progress in Hormone Research, Volume 46 provides a superior summary of the developments in the field of hormone research. The book discusses the molecular basis of androgen insensitivity; the tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1; and the molecular characterization of mammalian tachykinin receptors and a possible epithelial potassium channel. The text also describes the properties of the guanylate cyclase receptor family; insulin-like growth factor-binding proteins; and growth hormone receptor and binding protein. Mutations in the insulin receptor gene in genetic forms of insulin resistance; the characteristics of the cAMP response unit; and the role and secretion of inhibin in the rat are also considered. The book further tackles the structure of the lutropin/choriogonadotropin receptor and the gene for multiple endocrine neoplasia type 2a. Endocrinologists, physiologists, and biochemists will find the text invaluable.

Download or read book Ion Channels and Ion Pumps written by Piero P. Foa and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Omnis cellula e cellula, "every cell from a cell," was dogma to the 19th century cellular physiologist and the cornerstone of Virchow's Cellular pathologie. "Spread out a cell into a layer and you will find that, in ceasing to be a cell, it has ceased to act as such," wrote the British 1 physiologist G . R. Lewes more than a century age. "The cell remains vital as long as its wall remains intact . . . " keeping its content "pure and clear" and thus preserving the "vital principle" within, echoed Claude 2 Bernard a few years later. The notion of the cell membrane as a pro tecting envelope held sway until it became clear that it could not account for the "coalescence" of poorly differentiated embryonic "vesicles" and for their transformation into "cell-like structures" capable of auto regulation and yet subject to what the grandfather of one of us defined as the "federal obligations imposed by the whole organism. ,,3 A new concept was needed, and soon the membrane was described as a structure capable of uniting as well as separating adjacent cells. Morphologic evidence for this dual function was obtained several years later when the electron microscope revealed the existence of tight and gap junc tions which, acting as intercellular bonds and channels, allowed the cells to communicate with one another and thus coordinate their biologic activities.

Download or read book Humoral Factors in the Regulation of Tissue Growth written by Piero P. Foa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts in the field of endocrinology as well as ophthalmologists, oncologists, orthopedists and oral surgeons discuss the nature and mechanism of action of growth-stimulating substances whose biological and clinical activities in humans have been demonstrated or are being investigated. The monograph represents a good sampler of current basic and applied knowledge in the field.

Download or read book Pharmacology Biology and Clinical Applications of Androgens written by Chuck Kelly and published by John Wiley & Sons. This book was released on 1996-02-13 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology, Biology, and Clinical Applications of AndrogensCurrent Status and Future Prospects Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler,Ronald S. Swerdloff, Christina Wang, and Chuck Kelly As agents that affect the male primary and accessory sex organs,androgens--particularly the hormones testosterone andandrosterone--play a critical role in the development,functionality, and overall health of the male reproductive system.However, since androgens also have far-ranging effects onmetabolism, neurological activity, and behavior, scientistsexploring the contraceptive or therapeutic potential of androgensneed reliable, up-to-date information on the complex biologicalactivities of these agents. Pharmacology, Biology, and Clinical Applications of Androgens:Current Status and Future Prospects presents contributions fromleading investigators around the world, offering a focused,state-of-the-art summary of the central issues and controversies inandrogen research. The book is arranged into sections coveringandrogen physiology, androgens and the prostate, and theneurobehavioral and metabolic effects of androgens--as well astheir role in disease therapy and male contraception, and thevarious delivery systems for each application. Every chapter in thetext provides an expert opinion on a cutting-edge topic in thefield while highlighting the key points of dissent and disagreementwithin the scientific community. This approach is intended tofoster a deeper understanding of the status of androgen researchand lay the groundwork for future investigations in eacharea. This book explores such current topics as: * Androgen regulation of Sertoli cell function * Testosterone and spermatogenesis * Androgen effects on benign prostatic hyperplasia (BPH) andprostate cancer * Androgen effects on cognitive processes, sexual function, andaggressive behavior * Contraceptive efficacy of hormonal suppression of spermatogenesis * The latest transdermal and implantation delivery systems forandrogens Offering multifaceted coverage of the field, Pharmacology, Biology,and Clinical Applications of Androgens is an indispensable aid toall basic scientists and clinical investigators interested in thebiological actions of either natural or synthetic androgens.

Download or read book Controversies in Diabetes and Pregnancy written by Lois Jovanovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: As I read this unique volume on diabetes and pregnancy edited by Lois Jovanovic, I was struck by two themes that run throughout these collected chapters. First, this volume provides an excellent assessment of past problems, present management, and future challenges presented by dia betes in pregnancy. Orury's unique, longitudinal experience with diabetes iIi pregnancy provides the reader with an important overview, as does Coetzee's discussion of gestational diabetes. Current problems-deter mining the etiology and prevention of congenital malformations in infants of diabetic mothers (10M), assessment of antepartum fetal condition, management of pregnant patients with diabetic retinopathy, recognition of thyroid dysfunction in the pregnant diabetic woman, and understanding the multitude of metabolic sequelae observed in the 10M-are thoroughly reviewed. Finally, important considerations for future treatment and ther apy such as the adaptation of the fetal pancreas to the disordered intra uterine environment often seen in maternal diabetes, the use of fetal pan creatic tissue for transplantation, the application of exercise in the management of the pregnant woman with diabetes, and the long-term con sequences for the 10M provide an exciting glimpse into the future. The second important theme that emerges is the critical role the problem of diabetes in pregnancy has played in our understanding of maternal and fetal physiology. Clinical observations supported by basic research have emphasized the role of fetal fuels in teratogenesis.

Download or read book New Concepts in the Pathogenesis of NIDDM written by Claes-Goran Östenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book Endocrine Hypertension written by Karel Pacak and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.

Download or read book The Cumulative Book Index written by and published by . This book was released on 1989 with total page 2168 pages. Available in PDF, EPUB and Kindle. Book excerpt: A world list of books in the English language.

Download or read book The Endocrine Society Annual Meeting Program and Abstracts written by Endocrine Society and published by . This book was released on 1993 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: