Download or read book Hormonal Regulation of Mammary Tumors written by Benjamin S. Leung and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Download or read book Hormonal Regulation of Mammary Tumors written by Benjamin S. Leung and published by Springer London. This book was released on 1982 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormonal Regulation of Mammary Tumors written by Benjamin Leung and published by Springer. This book was released on 1983-03-31 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Download or read book Peptide and Other Hormones written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormonal Regulation of Mammary Gland Development and Breast Cancer written by and published by . This book was released on 2003 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the principal objectives of our laboratory is to understand the mechanisms by which hormones and growth factors regulate normal mammary gland development and how these same regulatory pathways become altered in breast cancer. Specific emphasis has been placed upon studying the mechanisms by which the lactogenic hormones, prolactin, hydrocortisone and insulin, regulate milk protein gene expression. The CCAAT/enhancer binding protein B (c/EBPB), Yin Yang-i (YY- 1), signal transducers and activators of transcription S (STATS), and the glucocorticoid receptor (OR) all have been shown to mediate the hormonal and developmental regulation of B-casein gene expression. However, the mechanism by which these transcription factors as well as coactivator proteins coordinately function to promote normal mammary gland development and breast cancer remains undefined. To understand the role of C/EBPj3, STATS, OR and comodulatory factors in hormonally-regulated chromatin remodeling at the 3-casein promoter and enhancer, we have initiated chromatin immunoprecipitation assays in HCl 1 cells and in the mammary gland and liver from lactating mice. In addition, we have analyzed mammary gland development in several specific mouse knockouts. The examination of mammary transplants from OR* and CBP mice suggested that MR may compensate for the loss of OR in mammary gland development during pregnancy, lactation and involution, and that haploinsufficiency of CBP does not appear to affect mammary gland development.
Download or read book Hormonal Regulation of Mammary Tumor Virus Expression in Normal and Neoplastic Mouse Mammary Cells in Vitro written by Jason Yang and published by . This book was released on 1977 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vitro Hormonal Regulation of Epidermal Growth Factor and Glucocorticoid Receptors in a Rat Mammary Tumor Clonal Line written by Ladan Basiripour and published by . This book was released on 1986 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormones and Cancer written by Wendell W. Leavitt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.
Download or read book Hormonal Regulation of Estrogen and Progesterone Receptors in Mouse Mammary Glands in Vivo written by Yuqian Zhou and published by . This book was released on 1998 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormonal Control of Lactation written by A. T. Cowie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on the hormonal control oflactation - the subject of this monograph - has long been the major interest of this laboratory. Studies were initiated in the mid 1930s by the late Professor S. 1. Folley, FRS, who directed the work with immense enthusiasm and devotion until his untimely death in 1970. This fruitful area of basic and applied research has, in recent years, attracted widespread attention; there have been many exciting events and developments with a dramatic increase in the number of publications. These events are diverse and include the identification, isolation and sequencing of human prolactin; the identification and isolation of placentallactogens in several ruminant species with recognition of their importance in mammary growth and differentiation; the introduction of highly sensitive bioassay, radioimmuno- and radioreceptor-assay techniques for mammotrophic hormones; the growing clinical appreciation of the immunological and nutritional importance of colostrum and milk to the newborn; the intensification of studies on normal mammogenesis to establish a sound basis for studies on mammary cancer; and the exploitation of the mammary gland, with its characteristic differentiation patterns and multiple synthetic abilities, as a valuable tissue for the investigation of basic mechanisms involved in the synthesis under hormonal control of enzymes and secretory proteins; and for the study of hormone - receptor interactions.
Download or read book Mechanisms of Altered Control of Proliferation by Cyclic Amp Protein Kinase A During Mammary Tumor Progression written by and published by . This book was released on 2001 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: Changes in signal transduction networks occur during mammary tumor progression that affect the proliferative response of the cells to exogenous factors. These alterations may be related to the loss of hormonal regulation of breast cancer which has a major impact on prognosis and therapy of breast cancer. The goal of this research was to identity the mechanisms underlying the difference in the proliferative response to 3'-5' cyclic adenosine monophosphate (cAMP) that we observed in our rodent model systems (Imagawa et aL 1992). cAMP is a potent mitogen for normal mammary gland epithelium, weakly nitogenic for hormone-dependent mammary tumors and growth inhibitory to hormone-independent mammary tumors. cAMP-stimulated proliferation was inhibited by pertussis toxin (PT) in normal mammary epithelium but neither the inhibitory effect of cAMP nor basal cAMP-independent proliferation of hormone-independent mammary tumors was affected by PT (Imagawa et al. 1995). PT is a bacterial toxin that ADP-ribosylates G(Delta)i(Beta)y subunits and blocks activation of receptor-coupled heterotrimeric G(Delta)i(Beta)y proteins. These findings indicate that through postreceptor crosstalk, pertussis toxin-sensitive Ga i
Download or read book Hormonal Control of Cell Cycle written by Shlomo Melmed and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as well as those deriving novel therapeutic approaches for these benign and malignant disorders.
Download or read book Hormones and Human Breast Cancer written by John Hayward and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Results in Cancer Research: Hormones and Human Breast Cancer provides information pertinent to the fundamental aspects of breast cancer and hormones. This book discusses the endocrine factors involved in breast cancer. Organized into two parts encompassing 11 chapters, this book begins with an overview of the process of castration as an effective therapeutic measure in many pre-menopausal patients with advanced breast cancer. This text then discusses the response rate following ablation wherein only 60 percent of patients subjected to hormone therapy as a first treatment for recurrence will survive to ablation. Other chapters consider the microscopical features of a tumor. This book discusses as well the prescription of corticosteroids as treatment, which originates from the mechanism of response that followed adrenalectomy or hypophysectomy. The final chapter deals with the use of radio-immunoassay methods in treating breast cancer. This book is a valuable resource for biochemists, scientists, and physicians.
Download or read book Experimental Studies on Hormonal Regulation of the Growth and Development of Breast Cancer written by Shouqi Luo and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Gene Expression by Hormones written by Kenneth McKerns and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Foundation for Biochemical Endocrinology is incorporated as a nonprofit research and educational organization. It is dedicated to the dissemination of knowledge, cooperative research programs, and cultural interaction on an international basis. The Foundation is concerned with both basic research and practical applications of biological knowledge to the betterment of humanity. Among our interests are global resource management, human reproduction, hormonal regulation of normal and cancer cells, study of aging and degenerative diseases, brain peptides, peptide neurotransmitter compounds, mechanism of action of hormones, peptide hormone synthesis, and recombinant DNA techniques. This monograph is the ninth sponsored by the Foundation in the Biochemical Endocrinology series. The previous four have been: Hormonally Active Brain Peptides: Structure and Function (1982), K. W. McKerns and V. Pantie, eds.; Reproductive Processes and Contraception (1981), K. W. McKerns, ed.; Synthesis and Release of Adenohypophyseal Hormones (1980), M. Jutisz and K. W. McKerns, eds.; and Structure and Function of the Gonadotropins (1978), K. W. McKerns, ed. These have all been published by Plenum Press.
Download or read book Hormones and Cancer written by Wendell W. Leavitt and published by Springer. This book was released on 2013-06-15 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.
Download or read book Estrogen antiestrogen Action and Breast Cancer Therapy written by Virgil Craig Jordan and published by Univ of Wisconsin Press. This book was released on 1986 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book marks one of the achievements of the "Estrogen and Antiestrogen Action: Basic and Clinical Aspects" Wisconsin Clinical Cancer Center conference in June 1984. It is not intended to be a recount of the meeting proceedings but is, rather, a historical review of the development of this field of endeavor during the past 30 years. The chapters have been written by many of the leading experts in the field who were asked to recount the development of a particular area or laboratory idea in which they had been personally involved. The book is intended to provide both scientists and clinicians with a single-volume overview of both the basic principles of hormonal control of breast cancer and the recent clinical results from cooperative groups around the world.
